ID   A0A4Z0Z0E1_9PEZI        Unreviewed;       642 AA.
AC   A0A4Z0Z0E1;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   28-JAN-2026, entry version 22.
DE   RecName: Full=Tyrosinase copper-binding domain-containing protein {ECO:0000259|PROSITE:PS00497, ECO:0000259|PROSITE:PS00498};
GN   ORFNames=E0Z10_g3899 {ECO:0000313|EMBL:TGJ84825.1};
OS   Xylaria hypoxylon.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Xylariomycetidae; Xylariales; Xylariaceae; Xylaria.
OX   NCBI_TaxID=37992 {ECO:0000313|EMBL:TGJ84825.1, ECO:0000313|Proteomes:UP000297716};
RN   [1] {ECO:0000313|EMBL:TGJ84825.1, ECO:0000313|Proteomes:UP000297716}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 108379 {ECO:0000313|EMBL:TGJ84825.1,
RC   ECO:0000313|Proteomes:UP000297716};
RA   Buettner E., Leonhardt S., Gebauer A.M., Liers C., Hofrichter M.,
RA   Kellner H.;
RT   "Draft genome sequence of Xylaria hypoxylon DSM 108379, a ubiquitous
RT   saprotrophic-parasitic fungi on hardwood.";
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC         Evidence={ECO:0000256|ARBA:ARBA00001973};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TGJ84825.1}.
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DR   EMBL; SKBN01000058; TGJ84825.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A4Z0Z0E1; -.
DR   STRING; 37992.A0A4Z0Z0E1; -.
DR   OrthoDB; 6132182at2759; -.
DR   Proteomes; UP000297716; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.310.20; -; 1.
DR   Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR050316; Tyrosinase/Hemocyanin.
DR   InterPro; IPR041640; Tyrosinase_C.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   PANTHER; PTHR11474:SF32; TYROSINASE; 1.
DR   PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   Pfam; PF18132; Tyrosinase_C; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR   PROSITE; PS00497; TYROSINASE_1; 1.
DR   PROSITE; PS00498; TYROSINASE_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000297716};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..642
FT                   /note="Tyrosinase copper-binding domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5021366207"
FT   DOMAIN          126..144
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00497"
FT   DOMAIN          331..342
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00498"
FT   REGION          440..465
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   642 AA;  72157 MW;  6270FCD423F62916 CRC64;
     MASIYTFVLF VSFFFSHGLA NIHSNKGYDY GHRMNLRVNK RDFGQSSIVG SLPLVDGQPQ
     PRLEIRTLQK NHDQWNLYIL ALSWMQYTSQ DSPFSWYQIA GIHGAPGQTW GNVAPLPGND
     NIGYCHHVSI LFPTWHRPYL VLYEQTMYNI VQFIASLWPP EDLDRVQEAA KRFRIPYWDW
     AVAPPAGESV FPLSIGGSSV VNVSGPNGIQ SVSNPLFSFA FKPFNGSIFP DSPYNKWNET
     KRAPYPISDP NAISNNSFVA ASFDKHLPSY QQRLYNLFAN YPNYTHFSNE GWIGQNNSGT
     FDSIESLHDS VHTIGGGGWG HLAIIAYSAF DPVFFLHHAN VDRIFAMWQV VHNDSYVVPT
     AAVYASHTQN QGDIEDIWTP LKPFFVNDTS FWTSGMVRDL ETFGYTYADV ANKTRGEVVA
     AINRLYTDYS PATITLRSNQ HSLSHADQEV DDQTPKTRSQ QHSHKSRVMA WRHEPISHLP
     MNVVFQVDSK GKSYREWIAN IEVKKHALKS SFLIYLFLGD VPDDSSSWQS LDNLVGSLGI
     FAGPDRSMRA EHGKVTGTIP LTSALMRMAV DGDVQSLAPE DVEQFLKPAL QLRIALVDGT
     VVSANEVDGL RISIVTSMVT IPTTEDQLPR WGEVKPIFDL VI
//