ID A0A4Z2AZ86_9TELE Unreviewed; 374 AA.
AC A0A4Z2AZ86;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 18-JUN-2025, entry version 24.
DE RecName: Full=IGFBP N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=fugu_007734 {ECO:0000313|EMBL:TNM85463.1};
OS Takifugu bimaculatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=433685 {ECO:0000313|EMBL:TNM85463.1, ECO:0000313|Proteomes:UP000516260};
RN [1] {ECO:0000313|EMBL:TNM85463.1, ECO:0000313|Proteomes:UP000516260}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TB-2018 {ECO:0000313|EMBL:TNM85463.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TNM85463.1};
RA Xu P., Liu B., Zhou Z.;
RT "The sequence and de novo assembly of Takifugu bimaculatus genome using
RT PacBio and Hi-C technologies.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the CCN family. {ECO:0000256|ARBA:ARBA00008125}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TNM85463.1}.
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DR EMBL; SWLE01000021; TNM85463.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4Z2AZ86; -.
DR Proteomes; UP000516260; Chromosome 8.
DR GO; GO:0031012; C:extracellular matrix; IEA:TreeGrafter.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0008201; F:heparin binding; IEA:TreeGrafter.
DR GO; GO:0005178; F:integrin binding; IEA:TreeGrafter.
DR GO; GO:0007155; P:cell adhesion; IEA:TreeGrafter.
DR GO; GO:0045597; P:positive regulation of cell differentiation; IEA:TreeGrafter.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:TreeGrafter.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR FunFam; 2.10.70.10:FF:000015; CYR61 isoform 1; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR050941; CCN.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR012395; IGFBP_CNN.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR043973; TSP1_CCN.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR11348; CONNECTIVE TISSUE GROWTH FACTOR-RELATED; 1.
DR PANTHER; PTHR11348:SF20; PROTEIN CYR61; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF19035; TSP1_CCN; 1.
DR Pfam; PF00093; VWC; 1.
DR PIRSF; PIRSF036495; IGFBP_rP_CNN; 1.
DR SMART; SM00041; CT; 1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00209; TSP1; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS50092; TSP1; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000516260};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..374
FT /note="IGFBP N-terminal domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5021494495"
FT DOMAIN 18..90
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 94..160
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 278..352
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
SQ SEQUENCE 374 AA; 41590 MW; 4E81AECC066BB393 CRC64;
MVFLAYLIAL TTAIITQVMA SCPAVCECPT ETLSCPPGVS LVPDGCGCCK VCAAQLNQDC
SSLRPCDHHK GLECNYGNDV TVAWGVCTAN SDGRTCEYNG RIYQNGETFR AGCKHQCSCI
DGAVGCAPLC TNKLPPASPS CPYPQLTRIP GQCCFSVDCH KGTWHLPPKY QAPPTRHMPK
PRIQQLENGL DSSHMEVKSS GWEGERGYKH LSVWNHLKDR KCPVQTTEWT QCSRSCGMGI
SSRITNKNPQ CKLERETRIC TIRPCNGITF PSKRGKKCSQ IHRVPEPVYL SYGECRSVRL
YRPSHCGTCT DGRCCSPRRT RTVPVSFVCP DDERFQRSVM FIQSCKCSSD CSHLNEVALP
PQYWMYGDTH MFTD
//
