ID A0A4Z2BHY2_9TELE Unreviewed; 390 AA.
AC A0A4Z2BHY2;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-NOV-2024, entry version 15.
DE RecName: Full=Suppressor of cytokine signaling 4 {ECO:0008006|Google:ProtNLM};
GN ORFNames=fugu_003039 {ECO:0000313|EMBL:TNM90750.1};
OS Takifugu bimaculatus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=433685 {ECO:0000313|EMBL:TNM90750.1, ECO:0000313|Proteomes:UP000516260};
RN [1] {ECO:0000313|EMBL:TNM90750.1, ECO:0000313|Proteomes:UP000516260}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TB-2018 {ECO:0000313|EMBL:TNM90750.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TNM90750.1};
RA Xu P., Liu B., Zhou Z.;
RT "The sequence and de novo assembly of Takifugu bimaculatus genome using
RT PacBio and Hi-C technologies.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TNM90750.1}.
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DR EMBL; SWLE01000016; TNM90750.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4Z2BHY2; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000516260; Chromosome 3.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF35; SUPPRESSOR OF CYTOKINE SIGNALING 4 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000516260};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 244..339
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 334..383
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 28..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 390 AA; 44102 MW; 7515EFB54C9ED6ED CRC64;
MSEKKPKGSG TRPKCGFRSW SADSYIWRSK KRSRNGSTPS GLDLEGTEEL GGRSTSCPRR
RRERMCSCTT LGDGPASADN DVVCRKALSR RSLRQKFQDA MGQCLPLRSH HHIHHHHPPS
SSRPFSVLFW SKRKIHVSEL MQEKCPFSPK SELARCWHLI KKYAAHPTAM KDMEAPLKPS
VSSSSTSPPQ TPLSWDDICC SPGPGNTSLE DWDPSCPHGG AEGSCNHTDY ILVPDLLQIS
NSPCYWGVLN RFEAEELLEG KPEGTFLLRD SAQDEYLFSV SFRRYSRSLH ARIEQNDKRF
SFDVHDPCVY QDSSVTGLLR HYSDPATCLF FEPLLSSPLS RTFPFSLQHL CRTLICSRTT
YQGVESLPLP PQLRDYLRQY HIKCDGACAF
//
