ID A0A507DM80_9FUNG Unreviewed; 873 AA.
AC A0A507DM80;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 18-JUN-2025, entry version 20.
DE RecName: Full=DBF4-type domain-containing protein {ECO:0000259|PROSITE:PS51265};
GN ORFNames=SeMB42_g01131 {ECO:0000313|EMBL:TPX52819.1};
OS Synchytrium endobioticum.
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Chytridiomycetes; Synchytriales;
OC Synchytriaceae; Synchytrium.
OX NCBI_TaxID=286115 {ECO:0000313|EMBL:TPX52819.1, ECO:0000313|Proteomes:UP000317494};
RN [1] {ECO:0000313|EMBL:TPX52819.1, ECO:0000313|Proteomes:UP000317494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MB42 {ECO:0000313|EMBL:TPX52819.1,
RC ECO:0000313|Proteomes:UP000317494};
RX PubMed=31209237; DOI=.1038/s41598-019-45128-9;
RA van de Vossenberg B.T.L.H., Warris S., Nguyen H.D.T.,
RA van Gent-Pelzer M.P.E., Joly D.L., van de Geest H.C., Bonants P.J.M.,
RA Smith D.S., Levesque C.A., van der Lee T.A.J.;
RT "Comparative genomics of chytrid fungi reveal insights into the obligate
RT biotrophic and pathogenic lifestyle of Synchytrium endobioticum.";
RL Sci. Rep. 9:8672-8672(2019).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TPX52819.1}.
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DR EMBL; QEAN01000027; TPX52819.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A507DM80; -.
DR STRING; 286115.A0A507DM80; -.
DR VEuPathDB; FungiDB:SeMB42_g01131; -.
DR Proteomes; UP000317494; Unassembled WGS sequence.
DR GO; GO:0031431; C:Dbf4-dependent protein kinase complex; IEA:TreeGrafter.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0043539; F:protein serine/threonine kinase activator activity; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0010571; P:positive regulation of nuclear cell cycle DNA replication; IEA:TreeGrafter.
DR GO; GO:1901987; P:regulation of cell cycle phase transition; IEA:TreeGrafter.
DR CDD; cd00027; BRCT; 1.
DR FunFam; 6.10.250.3410:FF:000001; Protein DBF4 homolog A; 1.
DR Gene3D; 6.10.250.3410; DBF zinc finger; 1.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR013939; Regulatory_Dfp1/Him1.
DR InterPro; IPR051590; Replication_Regulatory_Kinase.
DR InterPro; IPR006572; Znf_DBF.
DR InterPro; IPR038545; Znf_DBF_sf.
DR PANTHER; PTHR15375; ACTIVATOR OF S-PHASE KINASE-RELATED; 1.
DR PANTHER; PTHR15375:SF26; PROTEIN CHIFFON; 1.
DR Pfam; PF08630; Dfp1_Him1_M; 1.
DR Pfam; PF07535; zf-DBF; 1.
DR SMART; SM00586; ZnF_DBF; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR PROSITE; PS51265; ZF_DBF4; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000317494};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00600}.
FT DOMAIN 634..683
FT /note="DBF4-type"
FT /evidence="ECO:0000259|PROSITE:PS51265"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 38..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 688..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 822..846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..79
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..707
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..761
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..836
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 873 AA; 97538 MW; E7F12C729F40F46A CRC64;
MMSRNSVPLQ HLPTTPNLVR PSARPMGREM LHRNSALYAS AASRESSSRT RTATDDTMPS
LREATSTLTP ANPTTTTRAP LPPPAAVEAA KLRNVAIPAT GVKLISLPPS KPRCAAQVRD
SQLKRYLAAR QVTTPTRTKN SSKPLTSRTV SAPVTTVERF ATQQWGENHG LSWSKSTTTS
VRDTTKLTRP NSILRPSMSA LANTTNNIVN DNHPASQIQK METATASKPA LRVAKENSTV
EDENAVIGTS SRKPAFPPPA AQALVAASTN VTVKQQVIRN PIAQLRADNG TALKMPKALN
DPSNIHPIVT PMDEKSYIPA WREKLQRTVF YFYDLNPAQH RRLQKTVEVH GARVEKFLCP
RVTHVVQACM EVPLMSKNPD AKEGVPYKLP CPKIVEIDDG NGKRLKKVQP NPAEIIEHFK
NLGKKVWHVT RLLDVIQFLA PSKKRPLEEI LRDDFLYGPT TGRDETNSNF TPFHGEYLLV
EDVTRVYKPI IIKEFAMKPS DRNPPWPKVY TPNQINRCAF NAPPPSWLPT VNESYLEDVQ
DNFAVRSRVM WNGERETHYE KRKLSWDAAK SIALSKGNAS IPHDDIDELW RVASVEGRLV
TEQVKIKRDD CDLLVARIRT HQDDECRKPA GKAFYHRAGY CENCYDKYED FLEHISCPKH
RKFATNDDNF GELDDLLDTV RRPVDAPAFA DSSELSSDSR SIPSSADVTC GNESFGSWRE
GIFENEQEEA ENELAAEKKT CTITEEQEET ETDDDDDEND TAESNNNHDS NMSGSEYRFE
SGLPIDVAIF DGSDGCGSPN QDNDVDVDLF SPCKRRRIDD AEMDTRSTGQ TISSALSSVQ
DDDESQSSVK SFNMFESFGI AMNAMLSRPI FNH
//
