ID A0A511D1Q0_9PSEU Unreviewed; 620 AA.
AC A0A511D1Q0;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 28-JAN-2026, entry version 27.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=PA7_25420 {ECO:0000313|EMBL:GEL18705.1};
OS Pseudonocardia asaccharolytica DSM 44247 = NBRC 16224.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Pseudonocardia.
OX NCBI_TaxID=1123024 {ECO:0000313|EMBL:GEL18705.1, ECO:0000313|Proteomes:UP000321328};
RN [1] {ECO:0000313|EMBL:GEL18705.1, ECO:0000313|Proteomes:UP000321328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 16224 {ECO:0000313|EMBL:GEL18705.1,
RC ECO:0000313|Proteomes:UP000321328};
RA Hosoyama A., Uohara A., Ohji S., Ichikawa N.;
RT "Whole genome shotgun sequence of Pseudonocardia asaccharolytica NBRC
RT 16224.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GEL18705.1}.
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DR EMBL; BJVI01000024; GEL18705.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A511D1Q0; -.
DR STRING; 1123024.GCA_000423625_04115; -.
DR Proteomes; UP000321328; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:GEL18705.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000321328}.
FT DOMAIN 13..182
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 620 AA; 65171 MW; ED09E1B2C271F77A CRC64;
MRNSVRTLVR THGSQAVVAT AGHVDHGKST LVRALTGMEP DRWAEERRRG MTIDLGFVWT
TLENGQTVAF VDVPGHERFV STMLAGVGPV PAALFVVAAD EGWMPQSAEH LDAIEALGVR
NGLLVITRSD LLDPQLARDE AAEHLAGTGL AQVPAVCVSA VTGEGMDELR VALGELVAAL
PVPDPEADVR LWVDRSFTIR GAGTVVTGTL PAGRIRVDDD LELVAADGSS RRVTVRGLQS
LGRQVDEVCG VARVAVNLRG VPREAVARGD VLLRPGAWLI TDLLDVRLRG GRGTAPDPAA
LPVELTLHAG SAAVAARVRP LGADTVRLRL RHPVPLRIGD RAVLRDPGRR QVAAGATVLD
VRPPPLRHRG AAGRRAAELA GMDGVPDAAA ELARRGIARH AELIAMGVAV RDVDALVHTG
HPAAAGWLVD AGRAAELTAQ LTSAVTAHDA ADPLDPGLPI EAARRAAGLP EARLVEAVLR
CAAHTGGTEL LLREGRVTRS RAAGLPEAVL TALETLRAQL GRDPFAAPEA DRLAELGLGP
KQIASLVRAG ELLRIADGVV LLPRADDRAV EMLATLGPEF TLSAARQALG TTRRVAVPLL
ELLARTGRTI RTPDGGHRLV
//
