ID A0A511YJK2_9FLAO Unreviewed; 708 AA.
AC A0A511YJK2;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 28-JAN-2026, entry version 20.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=CHA01nite_11220 {ECO:0000313|EMBL:GEN75382.1};
OS Chryseobacterium hagamense.
OC Bacteria; Pseudomonadati; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Weeksellaceae; Chryseobacterium group; Chryseobacterium.
OX NCBI_TaxID=395935 {ECO:0000313|EMBL:GEN75382.1, ECO:0000313|Proteomes:UP000321863};
RN [1] {ECO:0000313|EMBL:GEN75382.1, ECO:0000313|Proteomes:UP000321863}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 105253 {ECO:0000313|EMBL:GEN75382.1,
RC ECO:0000313|Proteomes:UP000321863};
RA Hosoyama A., Uohara A., Ohji S., Ichikawa N.;
RT "Whole genome shotgun sequence of Chryseobacterium hagamense NBRC 105253.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GEN75382.1}.
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DR EMBL; BJYJ01000003; GEN75382.1; -; Genomic_DNA.
DR RefSeq; WP_146940339.1; NZ_BJYJ01000003.1.
DR AlphaFoldDB; A0A511YJK2; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000321863; Unassembled WGS sequence.
DR GO; GO:0043597; C:cytoplasmic replication fork; IEA:TreeGrafter.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:TreeGrafter.
DR GO; GO:0006281; P:DNA repair; IEA:TreeGrafter.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR025589; Toprim_C_rpt.
DR InterPro; IPR006171; TOPRIM_dom.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; NF005829; PRK07726.1; 1.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR Pfam; PF13342; Toprim_Crpt; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS52039; TOPO_IA_2; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:GEN75382.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000321863};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..134
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT DOMAIN 151..586
FT /note="Topo IA-type catalytic"
FT /evidence="ECO:0000259|PROSITE:PS52039"
FT REGION 430..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 708 AA; 80565 MW; 6F60E13E63362964 CRC64;
MKLCIAEKPS VARDIAKVLG ATMPKQGYME GNGYCVTWTF GHLCTLKEPH DYGPQYKSWN
LFLLPIIPQN FGIKLIPNKG VENQFKVIER LVEECDEVIN CGDAGQEGEL IQRWVLQKAK
CNKPIQRLWI SSLTEEAIKE GFSNLKPAEE YKNLYLAGNA RAIGDWLLGI NATRLFTKKF
GGNKAVLSIG RVQTPTLAML VQRQKEIDAF TTEEYWELKT KYRDVIFNAA IDRLKTLERA
EKGLEYLKQN PFEIVSFEIK EGKEKNPRLF DLTALQVEAN KKYGYSAENT LNYIQSLYEK
KHVTYPRVDT TYLSESLHPK IEGILRKMYF YQDLIAPLLE APIPKSKAVF DDTKVTDHHA
IIPTEVPPSQ NLSREEKLVY DLVAKRFIAV FYPECKISNT LVEGKVGTIP FKTSGRQVLE
PGWRAVYAKE PKEETADKEK EKEEEQTIPE FIVGETGPHD PKIHQGKTSP PKPYTEATLL
RAMETAGRQV EDEELREMLK NNGIGRPSTR ANIIETLFKR KYIEKKRKNL IATQTGIQLI
DTIEDELLKS PELTGEWESK LRKIESGQYE ANLFKEELIQ MVTELTKKVV DGKGKVISLE
EEKVEAVKEK KRREPAVKKE LASWEETQCP KCKAHHLLKG KTAVGCSDFK NCGFKVSFEI
FGKKLSDKQL MDLVMKGKTS KLKGFTSHPE ALAEGVLSMD ENFAVVLA
//
