ID A0A553P4L1_TIGCA Unreviewed; 1039 AA.
AC A0A553P4L1;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 02-APR-2025, entry version 18.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN ORFNames=TCAL_09958 {ECO:0000313|EMBL:TRY72627.1};
OS Tigriopus californicus (Marine copepod).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Hexanauplia; Copepoda; Harpacticoida; Harpacticidae; Tigriopus.
OX NCBI_TaxID=6832 {ECO:0000313|EMBL:TRY72627.1, ECO:0000313|Proteomes:UP000318571};
RN [1] {ECO:0000313|EMBL:TRY72627.1, ECO:0000313|Proteomes:UP000318571}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=San Diego {ECO:0000313|EMBL:TRY72627.1,
RC ECO:0000313|Proteomes:UP000318571};
RX PubMed=29988158; DOI=.1038/s41559-018-0588-1;
RA Barreto F.S., Watson E.T., Lima T.G., Willett C.S., Edmands S., Li W.,
RA Burton R.S.;
RT "Genomic signatures of mitonuclear coevolution across populations of
RT Tigriopus californicus.";
RL Nat. Ecol. Evol. 2:1250-1257(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TRY72627.1}.
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DR EMBL; VCGU01000008; TRY72627.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A553P4L1; -.
DR STRING; 6832.A0A553P4L1; -.
DR EnsemblMetazoa; TCAL_09958-PA_mrna; TRY72627.1; TCAL_09958.
DR Proteomes; UP000318571; Chromosome 7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProtKB-ARBA.
DR CDD; cd20338; BRcat_RBR_RNF19; 1.
DR CDD; cd20355; Rcat_RBR_RNF19; 1.
DR FunFam; 1.20.120.1750:FF:000001; RBR-type E3 ubiquitin transferase; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 2.20.25.20; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR SMART; SM00647; IBR; 2.
DR SMART; SM00184; RING; 2.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000318571};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 553..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 604..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 308..543
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 312..359
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 59..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1013..1039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..96
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..160
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..182
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..216
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..240
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..287
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..725
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..956
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1013..1028
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1039 AA; 111001 MW; 30027F64790E8773 CRC64;
MARPHPGQIE AGPRGHVAPD CGPTVSLAPS SSAPPSPPSL SGFSIARLTR GLSRDWARIS
IPPVATPPTT QMKFGWPKSS PSTAPPRQPS PAPRPTSAPV DWAGTATPTH PRRAKFEADR
RKEEQPRRKK ALPPFRTRLD LARAHSGLAG SSRPSASPGA DGLLPMPDSP PVRGRRPARF
SLRRLFDGHP LLPPPWGQPL TSAWPSRSRR PAHPHRNGAG LEEGGSRTNA TTPSSTRSRP
FFPPDSTSER SVTHPSSASS AGMNGRDWRG DSHAPYPSSS CASSLAGGSA GPSSAHYPAS
FVGADGRAMR ECSLCLVSLP LTEFPSLRNC HHLFCFDCLQ IYVKIELQEG RVNVRCPQCV
EPLHPNDIEL FIGDRNSNLQ HLYEFLMLRR ILATDPDTRW CPGPNCTFAV IAAGCASCPK
ITCERPGCGF SFCYHCKAEW HPNQTCDMAR AQRQGGHAQP GSLMMSMMNA STVSFSGQAD
SRGPQNPSEV KVCPRCDVLI VKMDDGSCNH MTCSVCGVEF CWLCMKEISD LHYLSPSGCT
FWGKKPWSRK KKLLWQLGTL VGAPVGIALL AGISIPAMII GIPVWVGRKL YAQYNKAPIH
KRNLIIASGV SASVIVSPVI AALAVSIGVP ILLAYVYGVV PISLCRSEGC GVSTSSNGVS
IDVDEELNPD TDLSHMPFRP MVMDNYSTAT GPSANWNPSI GEMSLGRSMS MGSTSHLDHE
ADRESASNTA VAGTSRTVSL ASSSVLMGGV TSIRGVSTEG LSETASLTDP NQDGASTRAL
AGSILAYKTD TQSVNSFRTG GDPSDILPAS GDEISLRSLP LGSVPSQLPR SLSPTASCRS
SGHEDIVRRS GRRRTNSNVP HLERQLSEDA EDTEAAALAL TGNDRVRFDD NVSFIDETGS
CTLMVNAPPT CIEEGLSAGV KTGNNKGLKS DKPCPSNSSS TPSTTTSVSI VSGSSNLNGP
TPIPLREETP EELAGMISPE IQRHYPASWS TRVNPSPCPD LIVSSSLNMS SNLEEKELEE
RQSADRNVTR LQIGEETDQ
//
