ID A0A554NFV0_9EURY Unreviewed; 145 AA.
AC A0A554NFV0;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 18-JUN-2025, entry version 17.
DE RecName: Full=Transcription elongation factor Spt5 {ECO:0000256|HAMAP-Rule:MF_00950, ECO:0000256|NCBIfam:TIGR00405};
GN Name=spt5 {ECO:0000256|HAMAP-Rule:MF_00950};
GN ORFNames=DP107_01530 {ECO:0000313|EMBL:TSD15890.1};
OS Haloglomus irregulare.
OC Archaea; Methanobacteriati; Methanobacteriota; Stenosarchaea group;
OC Halobacteria; Halobacteriales; Haloarculaceae; Haloglomus.
OX NCBI_TaxID=2234134 {ECO:0000313|EMBL:TSD15890.1, ECO:0000313|Proteomes:UP000319894};
RN [1] {ECO:0000313|EMBL:TSD15890.1, ECO:0000313|Proteomes:UP000319894}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F16-60 {ECO:0000313|EMBL:TSD15890.1,
RC ECO:0000313|Proteomes:UP000319894};
RA Duran-Viseras A., Sanchez-Porro C., Ventosa A.;
RT "Natronomonas sp. F16-60 a new haloarchaeon isolated from a solar saltern
RT of Isla Cristina, Huelva, Spain.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Stimulates transcription elongation. {ECO:0000256|HAMAP-
CC Rule:MF_00950}.
CC -!- SUBUNIT: Heterodimer composed of Spt4 and Spt5. Interacts with RNA
CC polymerase (RNAP). {ECO:0000256|HAMAP-Rule:MF_00950}.
CC -!- SIMILARITY: Belongs to the SPT5 family.
CC {ECO:0000256|ARBA:ARBA00006956}.
CC -!- SIMILARITY: Belongs to the archaeal Spt5 family. {ECO:0000256|HAMAP-
CC Rule:MF_00950}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TSD15890.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; QMDX01000001; TSD15890.1; -; Genomic_DNA.
DR RefSeq; WP_144260367.1; NZ_QMDX01000001.1.
DR AlphaFoldDB; A0A554NFV0; -.
DR FunCoup; A0A554NFV0; 1.
DR InParanoid; A0A554NFV0; -.
DR OrthoDB; 371863at2157; -.
DR Proteomes; UP000319894; Unassembled WGS sequence.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd06091; KOW_NusG; 1.
DR CDD; cd09887; NGN_Arch; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR HAMAP; MF_00950; Spt5_arch; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR006645; NGN-like_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR011590; Spt5_arc.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR NCBIfam; TIGR00405; KOW_elon_Spt5; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR SMART; SM00739; KOW; 1.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE 3: Inferred from homology;
KW Elongation factor {ECO:0000313|EMBL:TSD15890.1};
KW Protein biosynthesis {ECO:0000313|EMBL:TSD15890.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000319894};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00950};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00950}.
FT DOMAIN 1..81
FT /note="NusG-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00738"
FT DOMAIN 86..113
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
SQ SEQUENCE 145 AA; 15881 MW; 0F60F3EAD4A5F287 CRC64;
MGIFAVKTTA SQERTVADMI MSREEDSVHA ALAPDSLTSY VMVEADDISV FDRILDEIPH
SRGVVQGKSS IAEVEHFLSP KPDVEGIAES DIVELIAGPF KGEKAKVQRI DEGKDQVTVE
LYEATVPIPV TVRGDQIRVL DSDER
//
