ID A0A556THW7_BAGYA Unreviewed; 1459 AA.
AC A0A556THW7;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 02-APR-2025, entry version 22.
DE SubName: Full=DENN domain-containing protein 2A {ECO:0000313|EMBL:TSK13438.1};
GN ORFNames=Baya_0312 {ECO:0000313|EMBL:TSK13438.1};
OS Bagarius yarrelli (Goonch) (Bagrus yarrelli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Sisoridae; Sisorinae; Bagarius.
OX NCBI_TaxID=175774 {ECO:0000313|EMBL:TSK13438.1, ECO:0000313|Proteomes:UP000319801};
RN [1] {ECO:0000313|EMBL:TSK13438.1, ECO:0000313|Proteomes:UP000319801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JWS20170419001 {ECO:0000313|EMBL:TSK13438.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TSK13438.1};
RX PubMed=31274158;
RA Jiang W., Lv Y., Cheng L., Yang K., Chao B., Wang X., Li Y., Pan X.,
RA You X., Zhang Y., Yang J., Li J., Zhang X., Liu S., Sun C., Yang J.,
RA Shi Q.;
RT "Whole-Genome Sequencing of the Giant Devil Catfish, Bagarius yarrelli.";
RL Genome Biol. Evol. 11:2071-2077(2019).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TSK13438.1}.
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DR EMBL; VCAZ01000001; TSK13438.1; -; Genomic_DNA.
DR OrthoDB; 10266080at2759; -.
DR Proteomes; UP000319801; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:TreeGrafter.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0048568; P:embryonic organ development; IEA:TreeGrafter.
DR GO; GO:0035329; P:hippo signaling; IEA:TreeGrafter.
DR FunFam; 3.30.450.200:FF:000001; DENN domain-containing protein 2A isoform X1; 1.
DR FunFam; 3.40.50.11500:FF:000004; DENN domain-containing protein 2C isoform X1; 1.
DR FunFam; 2.70.50.80:FF:000001; Transcriptional enhancer factor TEF-1, putative; 1.
DR Gene3D; 2.70.50.80; -; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 6.10.20.40; TEA/ATTS domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR000818; TEA/ATTS_dom.
DR InterPro; IPR038096; TEA/ATTS_sf.
DR InterPro; IPR050937; TEC1_TEAD_TF.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR InterPro; IPR041086; YBD.
DR PANTHER; PTHR11834; TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED; 1.
DR PANTHER; PTHR11834:SF2; TRANSCRIPTIONAL ENHANCER FACTOR TEF-3; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF01285; TEA; 1.
DR Pfam; PF03456; uDENN; 1.
DR Pfam; PF17725; YBD; 1.
DR PRINTS; PR00065; TEADOMAIN.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00426; TEA; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS00554; TEA_1; 1.
DR PROSITE; PS51088; TEA_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000319801};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 580..988
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 1055..1131
FT /note="TEA"
FT /evidence="ECO:0000259|PROSITE:PS51088"
FT DNA_BIND 1055..1131
FT /note="TEA"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00505"
FT REGION 78..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..333
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 441..457
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..480
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1459 AA; 164346 MW; 1AF278C8A24E2D04 CRC64;
MPAASIMTGG RALLLCTNTE NCIYQSVNGL QCCGFRLEDA QSAVSNRPDL SRVVDTQSPL
TSLDNTDCLP ENMDMLTHKK PSDTNPVENG LEGFTKPTKP PKGLKSTASI REISQWEGKT
DSAGPNSQAV TQKETESVRK KDIKSTEVQR RDSKKAFGCD RQDLGKENGN RIGESRKSTE
ACTRERDVIL DKMPVGKTDI VQDKKSVLTH IKKLEQAMKE TPAKPSLPGN YFCPPSKDKQ
EEVEKRLTEP IFGTVEVVRG GSRRSRNRDP ENVYTEPGAP SINPLPKPQR TFQHHTQTNN
PGPSQSLAKG RRNLPPLPSI PPPPLPSCPP PPGVCLRPWQ EHTRDSNNRK SYEFEDLLQS
STEGCRVDWY AQAKLGLTHT LSEENVYEDI LDPPSKENPY EDIEVESHCA GNKYPVPLIP
SSPTLDTPTK LSSKPGFFRQ SSERRSFKLL DLRKTNRDGG IASPSRISPP STPSSPDDTP
CLSGDPYNRR RRKIPRMVLK INGIFEARRG KKKMKRVSPS TESSSGRVTD ENSESESDTE
EKLKAHSQRL VSVQSMLKQM DQYRTLEREL IDLQERKLFE YFLVVALHKT KAGAPYLPEV
TQQFPLKLER SFKFMREAED QLKVIPQFCF PDAKDWIPVE KFPSETFSFV LTGEDGSRRF
GYCRRLLPSG KGRRLPEVYC IVSRLGCFDL FSKMLDEVEK RRAISPALVQ PFMRGIMEAP
FPAPGRTITV KNFLPGSGTE VIELCRPSDS RLEHVDFECL FSSLNLRLLL KVFASLLLER
RVIFTADKLS TLSQCCHAVV ALLYPFTWQH TYIPVLPPSM MDIVCTPTPF IVGLLSSSLP
RLKELPLEEV LVVDLGNSRF LRQMDDEDSI LPHKLQTALE YVLEKRKELA SDRGDLPTEH
CSLSAVVSEA FVRFFVEIVG HYSLFMGGNE RDDESSASSL SPTPLSFQRD AFRKAVSSKS
LRHFLEVFME TQMFAAFIQE REMRRQGMRG LFEVRAQDYL DSLPGAENRG VNKFLKGLGL
LKPPNTTTLS AEWVSASSPG DASEELSEAL DKPLENDAEG VWSPDIEQSF QEALAIYPPC
GRRKIILSDE GKMYGRNELI ARYIKLRTGK TRTRKQVSSH IQVLARRKAR EIQVKLKDQA
AKDKALQSMA NMSSAQIISP AAYQNKMALQ SLSRPAYPTA GGFWHGALSG QPAPTEDIKP
FSQQNYVMQA TGPSITGYES ASGLSVSPSA PPWQGRSIAS SKLRMLEFSA FLEQPQDPEN
FNKHLFVHIG QSNPTYSDPY LEAVDIRQIY DKFPEKKGGL KELFEKGPAN AFFLVKFWAD
LSINLQDDSS FFYGVSSQYE SSENMIITSS TKVCSFGKQV VEKVEVRADV KTEYARFENG
RYVYRIHRSP LCEYMINFIH KLKHLPEKYM MNSVLENFTI LQVVTNRDTL ETLLCVAYVF
EVSTSEHGAQ HHIYRLVKD
//
