ID A0A556TJE5_BAGYA Unreviewed; 549 AA.
AC A0A556TJE5;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 05-FEB-2025, entry version 18.
DE SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|EMBL:TSK14858.1};
GN ORFNames=Baya_0841 {ECO:0000313|EMBL:TSK14858.1};
OS Bagarius yarrelli (Goonch) (Bagrus yarrelli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Sisoridae; Sisorinae; Bagarius.
OX NCBI_TaxID=175774 {ECO:0000313|EMBL:TSK14858.1, ECO:0000313|Proteomes:UP000319801};
RN [1] {ECO:0000313|EMBL:TSK14858.1, ECO:0000313|Proteomes:UP000319801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JWS20170419001 {ECO:0000313|EMBL:TSK14858.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TSK14858.1};
RX PubMed=31274158;
RA Jiang W., Lv Y., Cheng L., Yang K., Chao B., Wang X., Li Y., Pan X.,
RA You X., Zhang Y., Yang J., Li J., Zhang X., Liu S., Sun C., Yang J.,
RA Shi Q.;
RT "Whole-Genome Sequencing of the Giant Devil Catfish, Bagarius yarrelli.";
RL Genome Biol. Evol. 11:2071-2077(2019).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TSK14858.1}.
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DR EMBL; VCAZ01000002; TSK14858.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A556TJE5; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000319801; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000319801};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 394..489
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 484..533
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 132..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 61956 MW; C2CFDC6C60BA9E41 CRC64;
MSNGGGKEDL HYQEVAALMF LVPHLMEKVG KVWNNLKRGC QSLLHQDGNS REEMQPQTNA
YFQRLDKTQE QNTAELASPF SSSMTHPVGS RRVNGSVVHQ GHNCVVDVPQ ILEITVEQDS
EDRCGLLGTR RDSYSRHAPW SGKKRHSCST KAQSSLETTD RRSGRSRRRP LANGSRDEPD
PGVSRSLRQQ LHETMGLCLP LRLSFRGTHS RVPKRKIQIT ELMLETCPFP PGSDLARKWH
LIKQHTAPVT STAVDCTTDS PNAAVASQED EEDRLRERRR LSIEEGVDPP PDAQIHTIEA
ITAPMATVYK LGPKLAPGMG ESLGESRGAT AADCDSEDDD TTTLCLQARR PKQRHNSAEG
LLSGKQSGPW KVHTQIDYIH CLVPDLMQIT ALSCYWGVMD RYEAEALLDG RPEGTFLLRD
SAQEDYLFSV SFRRYGRSLH ARIEQWNHNF SFDAHDPCVF HAATVTALLE HYKDPSACMF
FEPLLTLPLH RTFPFDLQSL ARSVICRGTT YDGIAALPLP PALQDYLREY HYKQRVRVRW
LERELLKAQ
//
