ID A0A558RAD4_9SPHN Unreviewed; 706 AA.
AC A0A558RAD4;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 18-JUN-2025, entry version 26.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00044770};
DE EC=2.4.99.28 {ECO:0000256|ARBA:ARBA00044770};
GN Name=pbpC {ECO:0000313|EMBL:TVV76353.1};
GN ORFNames=FOY91_04530 {ECO:0000313|EMBL:TVV76353.1};
OS Sphingomonas solaris.
OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC Sphingomonadales; Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=2529389 {ECO:0000313|EMBL:TVV76353.1, ECO:0000313|Proteomes:UP000318681};
RN [1] {ECO:0000313|EMBL:TVV76353.1, ECO:0000313|Proteomes:UP000318681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R4DWN {ECO:0000313|EMBL:TVV76353.1,
RC ECO:0000313|Proteomes:UP000318681};
RA Tanner K., Pascual J., Mancuso C., Pereto J., Khalil A., Vilanova C.;
RT "Sphingomonas solaris sp. nov., isolated from a solar panel from Boston,
RT Massachusetts.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans,octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.99.28;
CC Evidence={ECO:0000256|ARBA:ARBA00049902};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the transpeptidase
CC family. {ECO:0000256|ARBA:ARBA00007090}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the
CC glycosyltransferase 51 family. {ECO:0000256|ARBA:ARBA00007739}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TVV76353.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; VNIM01000011; TVV76353.1; -; Genomic_DNA.
DR RefSeq; WP_145148672.1; NZ_VNIM01000011.1.
DR AlphaFoldDB; A0A558RAD4; -.
DR OrthoDB; 9766909at2; -.
DR UniPathway; UPA00219; -.
DR Proteomes; UP000318681; Unassembled WGS sequence.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:TreeGrafter.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR050396; Glycosyltr_51/Transpeptidase.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR011815; PBP_1c.
DR InterPro; IPR009647; PBP_C.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02073; PBP_1c; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF15; PENICILLIN-BINDING PROTEIN 1C; 1.
DR Pfam; PF06832; BiPBP_C; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000318681};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT DOMAIN 68..216
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 303..570
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 620..701
FT /note="Penicillin-binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06832"
SQ SEQUENCE 706 AA; 74739 MW; 8351F98FF52C79F5 CRC64;
MPSRLARHLL VAFALLGLGG LAWLWIATRP PAVPGFAAAR AAWRPSEAWL YDRDGRLLDS
ERVDFSVRRL GWTPLAATAP TLRKAVVLAE DHRFYAHDGV DWLATASALR TRVAGGRSRG
ASTITMQLAG FLGGDLARPG ARGWRDKLRQ MRAAWAIEAG WTKPQILEAY LNLAGFRGEA
QGVAAAAQTA FAKPPAALSR NEALLLVALL PDPRADAATV ARRACRLRGA GACDDLVAGA
EGMLASGRRL ALDPGLASHL AGRLLRRPGM RVRTMIDRTV QQAATTALRR QLLGLGATRA
RDGAVVVVEN ATGAVLAYVG GVGGAATAAA VDGANAYRQA GSTLKPFLYG LAMEHGWLPP
ASILDDAPVQ LDTASGLYVP QNYDRTFRGA VSARSALAGS LNVPAVRTLI LTGVEPFRDR
LWDAGYRGLT EDGAYYGFSL ALGSAEVTLL EQANAYRTLA NGGRFTPLRL TAGAPVQPAR
PVFTPQAAWL AADMMADPGA RAATFGLESA LRLPFWAAVK TGTSKAMRDN WCIGFTDRFT
VAVWVGNLEG DSMRAVSGTS GAAPVWREVM LALHRHRPGL PPPRPPGIEA RRVAFAGEIE
PTRREWFLAG TGQAALAAAP PGARRPRITA PVSGSVYALD PDIPLPRQRL RIAVAGGAAG
HRLLLDGRDL GAASASPLIL AGPGPHWLVL TDTGGRAVDR VLFTMR
//
