ID A0A562IMM9_9ACTN Unreviewed; 581 AA.
AC A0A562IMM9;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 28-JAN-2026, entry version 26.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=JD78_00639 {ECO:0000313|EMBL:TWH72132.1};
OS Modestobacter roseus.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Modestobacter.
OX NCBI_TaxID=1181884 {ECO:0000313|EMBL:TWH72132.1, ECO:0000313|Proteomes:UP000321490};
RN [1] {ECO:0000313|EMBL:TWH72132.1, ECO:0000313|Proteomes:UP000321490}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45764 {ECO:0000313|EMBL:TWH72132.1,
RC ECO:0000313|Proteomes:UP000321490};
RA Klenk H.-P.;
RT "R&d 2014.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TWH72132.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; VLKF01000001; TWH72132.1; -; Genomic_DNA.
DR RefSeq; WP_166520947.1; NZ_VLKF01000001.1.
DR AlphaFoldDB; A0A562IMM9; -.
DR Proteomes; UP000321490; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:TWH72132.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000321490}.
FT DOMAIN 1..170
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 581 AA; 60920 MW; 262F39E5E6935DFC CRC64;
MDVIATAGHV DHGKSTLVRA LTGMEPDRWE EERRRGLTID LGFAWTTLPG GRRLAVVDVP
GHERFVGNML AGVGSVPAAL VVVAADDGWS AQTAEHVAVL DALGVRHGLL AVTKADLADP
GPALADATER LAGTSLGRLP AVAVSARSGA GVPELTAALE GVLAALPAPD PAAAVRLWVD
RAFTIRGAGT VVTGTLAAGT VRAGDRFALG DREVTVRGLQ SLGAPVESAT ATARVALNLR
GVAVEEIARG DALLTPGAFR RTAELDVSLA TPTEDRLPAE LVVHIGSATV SARVRPLDGS
ALRLRLSAEL PLRVGDRLLL RDPGARRVLG ADVRDVDPPE LRRRGAARSR GAELAGQPAG
EAGALADLTR RRFVRRADFV AMGWPVPADA TEVGPWLIAP GLADELAARV PQVVARYRQL
RPLETGPPIA VLRSALELPD ADLVPAVVRP PLALRDGRVV AGSAGLPPHV QRAVDEVRAR
LAGAPFAAPE APDLVAAGLG PRELAAAVRD EQLVRIAEGI YLAPGVAEEA RRRLAGLPQP
FTLSDARKAW DTTRRVAVPL AEWLDARGVT VRQPDNTRRL R
//
