ID A0A562JAB1_9FIRM Unreviewed; 633 AA.
AC A0A562JAB1;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 28-JAN-2026, entry version 27.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=LY60_02163 {ECO:0000313|EMBL:TWH79844.1};
OS Sedimentibacter saalensis.
OC Bacteria; Bacillati; Bacillota; Tissierellia; Sedimentibacter.
OX NCBI_TaxID=130788 {ECO:0000313|EMBL:TWH79844.1, ECO:0000313|Proteomes:UP000315343};
RN [1] {ECO:0000313|EMBL:TWH79844.1, ECO:0000313|Proteomes:UP000315343}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13558 {ECO:0000313|EMBL:TWH79844.1,
RC ECO:0000313|Proteomes:UP000315343};
RA Kyrpides N.;
RT "Genomic Encyclopedia of Type Strains, Phase I: the one thousand microbial
RT genomes (KMG-I) project.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TWH79844.1}.
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DR EMBL; VLKH01000005; TWH79844.1; -; Genomic_DNA.
DR RefSeq; WP_145083206.1; NZ_JBCFAR010000001.1.
DR AlphaFoldDB; A0A562JAB1; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000315343; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR PANTHER; PTHR43721:SF11; SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:TWH79844.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000315343}.
FT DOMAIN 1..174
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 633 AA; 71921 MW; 791248095D9A9C77 CRC64;
MNIIIGTAGH IDHGKTTLIK ALTGRDTDRW EEEKRRGITI DLGFTYFDLP DGNQAGIIDV
PGHEKFIKNM LAGVIGMDLV LLVIAADEGI MPQTTEHLNI LNLLGLKKGI VVLTKYDLID
AEWLELVKED IKEALKDTFL ENAPMVEVSS KTGYGIDNLV NVICKTTETE VEQRDLSTIP
RLPIDRVFSI TGFGTVITGT LISGTLKKGD EVEIYPVNKI SKVRNIQVHS HDAEKAYAGQ
RTAINLSNVK KTDLYRGCVI APVNAMKNTM MLDVKLNLLK SSRRIVENRS RLHLYTGTSE
ILCRVVLLDC DELSPGESCY AQLRLEQEIA VRRGDKFIIR FYSPMETIGG GEIIEPVPLK
KKRFDDKLIE ELKVKEKGSG TDVIEKIIRE NSKNVPSISE LAKLTALRED EIKNSIEVLE
DEEKITTFRL KNDIYLWHKS FEREIEEGIE KYLFDFHEKN KYQKGAKKSE VKSKFLPAIK
QNVFDLAIMS FVQKGMLKMD GEFVSLAYFS IQHDEAYEKT AVAAEKILEE AKFEFLKQDE
LIQRLNLHKS EEIISLLIDE KKLVKIGELG ITKMEIYDEA KNILVNFITK NQKITAAEYR
DLLNSNRKVA IGLLEHFDII KVTRRVGNDR VLF
//
