ID A0A562QRA9_9BACI Unreviewed; 636 AA.
AC A0A562QRA9;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 28-JAN-2026, entry version 29.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=IQ10_01007 {ECO:0000313|EMBL:TWI59292.1};
OS Halalkalibacter nanhaiisediminis.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
OC Halalkalibacter.
OX NCBI_TaxID=688079 {ECO:0000313|EMBL:TWI59292.1, ECO:0000313|Proteomes:UP000315711};
RN [1] {ECO:0000313|EMBL:TWI59292.1, ECO:0000313|Proteomes:UP000315711}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.10116 {ECO:0000313|EMBL:TWI59292.1,
RC ECO:0000313|Proteomes:UP000315711};
RX PubMed=26203337; DOI=.1186/s40793-015-0017-x;
RA Whitman W.B., Woyke T., Klenk H.P., Zhou Y., Lilburn T.G., Beck B.J.,
RA De Vos P., Vandamme P., Eisen J.A., Garrity G., Hugenholtz P.,
RA Kyrpides N.C.;
RT "Genomic Encyclopedia of Bacterial and Archaeal Type Strains, Phase III:
RT the genomes of soil and plant-associated and newly described type
RT strains.";
RL Stand. Genomic Sci. 10:26-26(2015).
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TWI59292.1}.
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DR EMBL; VLKZ01000002; TWI59292.1; -; Genomic_DNA.
DR RefSeq; WP_144449441.1; NZ_VLKZ01000002.1.
DR AlphaFoldDB; A0A562QRA9; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000315711; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR PANTHER; PTHR43721:SF11; SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:TWI59292.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000315711}.
FT DOMAIN 1..174
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 636 AA; 72701 MW; 91DEFFF1AED6022C CRC64;
MNHYTVGMAG HIDHGKTTLT KALTNIDTDR LKEEQERQIS IELGYAPLKL NDEMEVSLID
VPGHERFIRQ MIAGVAGIDL VMLVVAADEG VMPQTREHID ILRLLGIEQG IIVVTKMDRV
DEEMHELVEL DIRETVEGTF LEDAKVFFVD SKSGVGIDQL KTELAHELAG LSSRDASGAF
RLPIDQVFTV HGQGTVVRGT VYEGVVKEGD VLEILPQKKS VRARQLQVHH EPRQNGRAGQ
RVAVNLGGIG KDEIKRGDVL AASGHYEATD TIDVSLHTVA ELRYSIKQRS AIKLHIGTAE
VYGKIVFFDR NELTEGNEEM VCQLRLDEPI VTRRGDRFIL RRPTPMETIG GGTVIDAHGQ
KYRFGEETVR TLEQKKAATP EEQFQQLILE KKLLTIKEAS NSVHLSEEQL AKWMDEQAQF
IILPTGEITS EKVIQSLRES IEAELAHYHL EYPLRQGIKK AELVQSYLQT YPKKILEWMI
EEGGDKQWLT LEGPYVALGS HSPHPPEKWA KRVEHVMKAI QEEDLQVSPV FEHIQKQQIP
QDLFEELIHY FHQQEILFQI DDKLSIHAEP FKQAIREMKE KTNESFSLQE AKEVTGLSRK
YLVPFLEKID KLGLTIRQEQ ERRWTDDYEQ EWLYKR
//
