ID A0A563UIK3_9SPHI Unreviewed; 796 AA.
AC A0A563UIK3;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 18-JUN-2025, entry version 28.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00044770};
DE EC=2.4.99.28 {ECO:0000256|ARBA:ARBA00044770};
GN Name=pbpC {ECO:0000313|EMBL:TWR31197.1};
GN ORFNames=FPZ43_01600 {ECO:0000313|EMBL:TWR31197.1};
OS Mucilaginibacter pallidiroseus.
OC Bacteria; Pseudomonadati; Bacteroidota; Sphingobacteriia;
OC Sphingobacteriales; Sphingobacteriaceae; Mucilaginibacter.
OX NCBI_TaxID=2599295 {ECO:0000313|EMBL:TWR31197.1, ECO:0000313|Proteomes:UP000320042};
RN [1] {ECO:0000313|EMBL:TWR31197.1, ECO:0000313|Proteomes:UP000320042}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=dk17 {ECO:0000313|Proteomes:UP000320042};
RA Kim J.;
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans,octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.99.28;
CC Evidence={ECO:0000256|ARBA:ARBA00049902};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the transpeptidase
CC family. {ECO:0000256|ARBA:ARBA00007090}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the
CC glycosyltransferase 51 family. {ECO:0000256|ARBA:ARBA00007739}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TWR31197.1}.
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DR EMBL; VOEJ01000001; TWR31197.1; -; Genomic_DNA.
DR RefSeq; WP_146380094.1; NZ_VOEJ01000001.1.
DR AlphaFoldDB; A0A563UIK3; -.
DR OrthoDB; 9766909at2; -.
DR Proteomes; UP000320042; Unassembled WGS sequence.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:TreeGrafter.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR050396; Glycosyltr_51/Transpeptidase.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR011815; PBP_1c.
DR InterPro; IPR009647; PBP_C.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02073; PBP_1c; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF15; PENICILLIN-BINDING PROTEIN 1C; 1.
DR Pfam; PF06832; BiPBP_C; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000320042};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT DOMAIN 66..226
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 311..569
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 701..789
FT /note="Penicillin-binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06832"
SQ SEQUENCE 796 AA; 88882 MW; 2652467D8BACFA03 CRC64;
MPFSTTRFNR FFRKPKVTII GLFLILFGAW FIFCLPRPLF NSPTSYVIDD DAGQLLGASI
AADGQWRFPV DAHVPSKFSA CIIAFEDKRF NYHPGFDPLA FARAVKLNVS AKKATSGGST
ITMQVVRLAT HHKRTFWNKI VEVFMAMRLE MGYSKQNILS LYAGNAPFGS NVVGLDAAAW
RYFGRRADKL SWGEMAALAV LPNSPSLVHP GKNRKVMLRK RNRLLDVLYK QGTIDSTTAA
LAKFEPMPEK PVALPQLTTH LLQRFKADYK RKPEGNTRIT TTIKTSLQQQ VADILEKHHR
VLKANDINNI AAVVLDVETG AALAYVGNIN HRDDPEMESD VDVIAAPRSP GSTLKPLLYA
SMLHDGLILP NSLIPDVPTQ IAGYHPENFD LGYDGAVPAS NALSRSLNIP AVKMLQQYKY
ERFYDKLRKI GITTLNKPAD HYGLALILGG GENTLWELTG AYAGMARVLN HYNISSRYTN
ADYHSPIYIK RPSSQKPNDK NGLLNAGSLY YTLQAMEEVM RPGEEMLWQQ FSSTQRIAWK
TGTSFGFRDG WAIGLTPKYV VGVWVGNTDG EGRPGLTGIN TAAPVLFDIF RLLPAAREWF
AVPTGDMVRI KVCKESGYRA GQYCDDATEQ LVPKSGLKAQ VCPWHKLVNL DKAGRYQVTS
NCMSPADMLN KSWFVLPPSM EYYYKARDYQ YRVLPPFMPG CDNIEAAPME LIYPKDGAKV
YVPLEADGRR GRLICNAAHR LTGTKIYWHL DDKFAGTTTS FHQIDLNPSP GKHKLTLVDA
AGNTLHINFE VLDKNK
//
