ID A0A5A7WAJ1_9MYCO Unreviewed; 551 AA.
AC A0A5A7WAJ1;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 18-JUN-2025, entry version 24.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=CIW52_34350 {ECO:0000313|EMBL:KAA0074249.1};
OS Mycolicibacterium sp. P9-64.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Mycobacteriaceae; Mycolicibacterium.
OX NCBI_TaxID=2024612 {ECO:0000313|EMBL:KAA0074249.1, ECO:0000313|Proteomes:UP000323700};
RN [1] {ECO:0000313|EMBL:KAA0074249.1, ECO:0000313|Proteomes:UP000323700}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P9-64 {ECO:0000313|EMBL:KAA0074249.1,
RC ECO:0000313|Proteomes:UP000323700};
RA Barrio Duque A.D., Antonielli L.;
RT "Interaction between fungi and bacteria.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA0074249.1}.
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DR EMBL; NPKO01000021; KAA0074249.1; -; Genomic_DNA.
DR RefSeq; WP_149375848.1; NZ_NPKO01000021.1.
DR AlphaFoldDB; A0A5A7WAJ1; -.
DR OrthoDB; 9792686at2; -.
DR Proteomes; UP000323700; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR033463; sCache_3.
DR InterPro; IPR029151; Sensor-like_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR016120; Sig_transdc_His_kin_SpoOB.
DR InterPro; IPR039506; SPOB_a.
DR PANTHER; PTHR43547:SF10; SENSOR HISTIDINE KINASE DCUS; 1.
DR PANTHER; PTHR43547; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF17203; sCache_3_2; 1.
DR Pfam; PF14689; SPOB_a; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR SUPFAM; SSF55890; Sporulation response regulatory protein Spo0B; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KAA0074249.1};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000323700};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 225..267
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 347..540
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 551 AA; 57598 MW; F82E77AE5F04A8C6 CRC64;
MSTRNRTLGR TKFSTPRIAA RSLAGQFLVF QLLVVLVVLG AVAAVSVTQS NQEFREVRGQ
RMIAVAENLS STPIVRERYA DPAAALVLAP DVDRAVALSG AALVEILAPD GRVRVSSDPS
RAGDRTDFGR SQVVKGRAWS GDLDVDGAHS LVGQVPILAI DGSVLAIVSV SEPYPSTWQL
LSGAGERLLV YLGLGAALGV LASWLLSRRI KRHTRGLEVA EIAGLADHRE ALLHSIREGV
VAVNTDGVIT LLNDSAQDLL GVTGDAVGRR IDTVGLDPAV EEFLASGENS RDVVIVTRTR
VLALNRRAAS TGGERIGTVT TMRDSTELAS MQGQLSSHKS VTDTLRAQTH EFANQLHTIS
GLVQLGEYDS VRDLVGTLTR RRAEISDAVT RHVADPAVAA LLIAKTSLAA ESGVALVLDE
RSHLAALDPA LATDVITVLG NLIDNAVDVS EGSQRRVVTV TLGDTGALTI SVADSGPGVP
EHLRETIFAR GVTSKPDVPG GRGIGLALVR LVSAQLGGAV EVSDGPDGGA VFEVRLPLSR
SAPRAGGSAD A
//
