ID A0A5A7WX62_9MYCO Unreviewed; 229 AA.
AC A0A5A7WX62;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 18-JUN-2025, entry version 20.
DE RecName: Full=Iron-dependent repressor IdeR {ECO:0000256|ARBA:ARBA00069799};
GN ORFNames=CIW52_11940 {ECO:0000313|EMBL:KAA0084678.1};
OS Mycolicibacterium sp. P9-64.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Mycobacteriaceae; Mycolicibacterium.
OX NCBI_TaxID=2024612 {ECO:0000313|EMBL:KAA0084678.1, ECO:0000313|Proteomes:UP000323700};
RN [1] {ECO:0000313|EMBL:KAA0084678.1, ECO:0000313|Proteomes:UP000323700}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P9-64 {ECO:0000313|EMBL:KAA0084678.1,
RC ECO:0000313|Proteomes:UP000323700};
RA Barrio Duque A.D., Antonielli L.;
RT "Interaction between fungi and bacteria.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DtxR/MntR family.
CC {ECO:0000256|ARBA:ARBA00007871}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA0084678.1}.
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DR EMBL; NPKO01000003; KAA0084678.1; -; Genomic_DNA.
DR RefSeq; WP_149371457.1; NZ_NPKO01000003.1.
DR AlphaFoldDB; A0A5A7WX62; -.
DR OrthoDB; 3208141at2; -.
DR Proteomes; UP000323700; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:TreeGrafter.
DR FunFam; 1.10.60.10:FF:000001; Iron dependent repressor; 1.
DR FunFam; 1.10.10.10:FF:000067; Iron-dependent repressor IdeR; 1.
DR Gene3D; 2.30.30.90; -; 1.
DR Gene3D; 1.10.60.10; Iron dependent repressor, metal binding and dimerisation domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR040767; DtxR/IdeR_SH3.
DR InterPro; IPR050536; DtxR_MntR_Metal-Reg.
DR InterPro; IPR007167; Fe-transptr_FeoA-like.
DR InterPro; IPR001367; Fe_dep_repressor.
DR InterPro; IPR036421; Fe_dep_repressor_sf.
DR InterPro; IPR038157; FeoA_core_dom.
DR InterPro; IPR022687; HTH_DTXR.
DR InterPro; IPR022689; Iron_dep_repressor.
DR InterPro; IPR008988; Transcriptional_repressor_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33238; IRON (METAL) DEPENDENT REPRESSOR, DTXR FAMILY; 1.
DR PANTHER; PTHR33238:SF10; IRON-DEPENDENT REPRESSOR IDER; 1.
DR Pfam; PF18357; DtxR; 1.
DR Pfam; PF02742; Fe_dep_repr_C; 1.
DR Pfam; PF01325; Fe_dep_repress; 1.
DR SMART; SM00899; FeoA; 1.
DR SMART; SM00529; HTH_DTXR; 1.
DR SUPFAM; SSF50037; C-terminal domain of transcriptional repressors; 1.
DR SUPFAM; SSF47979; Iron-dependent repressor protein, dimerization domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50944; HTH_DTXR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Reference proteome {ECO:0000313|Proteomes:UP000323700};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 4..65
FT /note="HTH dtxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50944"
SQ SEQUENCE 229 AA; 25425 MW; 08BC66DC7250AA1E CRC64;
MNDLIDTTEM YLRTIYDLEE EGVVPLRARI AERLEQSGPT VSQTVSRMER DGLLHVAGDR
HLELTDKGRA LAVSVMRKHR LAERLLVDVI GLPWEEVHAE ACRWEHVMSE DVERRLVQVL
DNPTTSPFGN PIPGLAELGI VPSGADDVAL VRLTELPTGF PVAVRVRQLT EHVQGDIELI
ARLKDAGVVP SARVTVQVNE HGSVMIVIPG HEQVELPHHM AHAVKVEKV
//
