ID A0A5A9NEZ0_9TELE Unreviewed; 1480 AA.
AC A0A5A9NEZ0;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 18-JUN-2025, entry version 22.
DE RecName: Full=Nuclear receptor coactivator 3 {ECO:0000256|ARBA:ARBA00067176};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
GN ORFNames=E1301_Tti010456 {ECO:0000313|EMBL:KAA0707785.1};
OS Triplophysa tibetana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Nemacheilidae; Triplophysa.
OX NCBI_TaxID=1572043 {ECO:0000313|EMBL:KAA0707785.1, ECO:0000313|Proteomes:UP000324632};
RN [1] {ECO:0000313|EMBL:KAA0707785.1, ECO:0000313|Proteomes:UP000324632}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TTIB1903HZAU {ECO:0000313|EMBL:KAA0707785.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAA0707785.1};
RX PubMed=30977968;
RA Yang X., Liu H., Ma Z., Zou Y., Zou M., Mao Y., Li X., Wang H., Chen T.,
RA Wang W., Yang R.;
RT "Chromosome-level genome assembly of Triplophysa tibetana, a fish adapted
RT to the harsh high-altitude environment of the Tibetan Plateau.";
RL Mol. Ecol. Resour. 19:1027-1036(2019).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein]
CC + CoA + H(+); Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-
CC COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
CC Evidence={ECO:0000256|ARBA:ARBA00048017};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC family. {ECO:0000256|ARBA:ARBA00009933}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA0707785.1}.
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DR EMBL; SOYY01000019; KAA0707785.1; -; Genomic_DNA.
DR Proteomes; UP000324632; Chromosome 19.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0016922; F:nuclear receptor binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:InterPro.
DR GO; GO:0032870; P:cellular response to hormone stimulus; IEA:TreeGrafter.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:TreeGrafter.
DR CDD; cd00130; PAS; 1.
DR FunFam; 3.30.450.20:FF:000008; Nuclear receptor coactivator; 1.
DR FunFam; 4.10.280.10:FF:000008; Nuclear receptor coactivator; 1.
DR FunFam; 3.30.450.20:FF:000027; Nuclear receptor coactivator 3; 1.
DR Gene3D; 6.10.140.410; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR056193; bHLH_NCOA1-3.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR010011; NCO_DUF1518.
DR InterPro; IPR032565; NCOA2/3_DUF4927.
DR InterPro; IPR009110; Nuc_rcpt_coact.
DR InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR014935; SRC/p160_LXXLL.
DR PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR PANTHER; PTHR10684:SF3; NUCLEAR RECEPTOR COACTIVATOR 3; 1.
DR Pfam; PF23172; bHLH_NCOA; 1.
DR Pfam; PF16279; DUF4927; 1.
DR Pfam; PF16665; NCOA_u2; 1.
DR Pfam; PF08815; Nuc_rec_co-act; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR Pfam; PF08832; SRC-1; 1.
DR SMART; SM01151; DUF1518; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000313|EMBL:KAA0707785.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000324632};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00023315}.
FT DOMAIN 22..79
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 114..177
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 488..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..626
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..721
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..797
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..827
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..847
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1480 AA; 158300 MW; 4D94B946D8A9AD65 CRC64;
MSRVGENSLE PLCSDRKRKL STCDTPGQGC DKRRREQESK YIEELAELIS ANLGDIDSFN
VKPDKCAILK ETVRQIRQIK EQGKSSCGDD DVQKADVSST GQGVIDKDHL GPLLLQALDG
FLFVVSREGS IVFVSDNVTQ YLQYKQEELI NTSIYNILHE EDRGELLKNL PKSNGSNSVS
WGGDASRQKS HTFNCRMLMK FGHGGPGGEE GGGGPRYETM QCFALTQPKA MMEEGEDLQS
CMICVARRVT AVERTERFST RHELSGKLIE IEQQSLLHTT MRPGWEDLVR RCMQMFLHRS
EGQPWSYKRH YQEAYVHGRA ETPLYRFSLS DGTPVTAQTR SELCRNTVTN EPLTFLSTHL
LQREQNGYRP NQGGVMRSVM SNTNPNAQLS MPPGGGMGMG NTRAYGMNEQ AHMGPRGGPM
YGPGNRMNQI NPMHQMNQMN MNQMNSMTQM GSMNQMNSMG QMNHMGHPGM NQHQPGQFHG
GSYGMGMTSP SQGSPALNPP QQNLIGSPRI RGSPKMGASP FSPGGMNSPM GPVSMGGTGG
SSAPTVGNTF SSSSLNALQA ISEGVGSSLP SALNSPAHKS DSSPSINSTQ TSQQGQTGNN
KPGNSDSKSP SSSHSSAVDQ QQASSSETTM EKPDSQSSKD VSAGPEVNRR LSDGKGHKKL
LQLLTSPTED IGHATGGPVP GRASTPMSLE SKETGGGMMS PSSTGVSSSS GSSSGNNANQ
QGSGGVSSTA CPSGSHTVQE KHKILHKLLK NGNTPDEVAR ITAEATGKAS LGAEHPGAEA
RNLELKQEQL SPKEVKKPAL LHYLLNKDDS KDPNPTEAKP KLEELEGRGS MGGQGSGVTT
SNSNNQEGKV KLEPPDEMDS LESILGGLRN PTSGLFADSR TGGSVGGNKQ GNGPNSTAHD
REGVGMVSSQ RVPFQRAVSV DGKPLIGPGM SGRRSAPSSL VKQEHTENQM AMGGPNRPMG
MNRPPMAGAG DWGMSSSSPV GHPGMGRPGM DHNPKGMMGA PMVNRSNSVP ANRSILQQQL
MEMGPYEVGI GMTAFRGQGP PPRSPSWPDN GMGMEGAQNT NRLPFNNSLD DLLVPPSTTE
GQSDERALLD QLDSLLNNTD VMALEEIDRA LGIPDLVSQG HSTEQAPPTD PFSAPCPDST
LGMDPKGMYG QGYPGPPSMG MQGGYGHGPS PGPGPMQGQS GPGFNPIMNP MNQQGAFPGM
GGMGGMHPRA TMMRPRMMNP TKPLRLQLQQ RLQGQQFLNQ NRQGMGMGMR PDNSPAGNPN
MRPNMQPGMA GQPGFLNAQM MAQRSREMLN LSEMRRQRMM MVMQQQQQQQ QQVAPGGFSP
PPNVTAPTVM DNPMGGPPMN QSSQQAFNYG GNYGMGQQGD PSFVGTGTSP PNNMMCGRMG
GPQNPMMQQH PQSNPMYQSA EMKGWGQGPM PMNSSYSQQQ QYPQQGAQGQ YGGMMMNGSM
QGVVNGNSAG QMPPMQGQMG MNGMGMGRMP MGPDQVHNVI
//