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Database: UniProt
Entry: A0A5A9NH96_9TELE
LinkDB: A0A5A9NH96_9TELE
Original site: A0A5A9NH96_9TELE 
ID   A0A5A9NH96_9TELE        Unreviewed;       770 AA.
AC   A0A5A9NH96;
DT   13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2019, sequence version 1.
DT   18-JUN-2025, entry version 17.
DE   SubName: Full=Rho guanine nucleotide exchange factor 6 {ECO:0000313|EMBL:KAA0709372.1};
GN   ORFNames=E1301_Tti004203 {ECO:0000313|EMBL:KAA0709372.1};
OS   Triplophysa tibetana.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Nemacheilidae; Triplophysa.
OX   NCBI_TaxID=1572043 {ECO:0000313|EMBL:KAA0709372.1, ECO:0000313|Proteomes:UP000324632};
RN   [1] {ECO:0000313|EMBL:KAA0709372.1, ECO:0000313|Proteomes:UP000324632}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TTIB1903HZAU {ECO:0000313|EMBL:KAA0709372.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:KAA0709372.1};
RX   PubMed=30977968;
RA   Yang X., Liu H., Ma Z., Zou Y., Zou M., Mao Y., Li X., Wang H., Chen T.,
RA   Wang W., Yang R.;
RT   "Chromosome-level genome assembly of Triplophysa tibetana, a fish adapted
RT   to the harsh high-altitude environment of the Tibetan Plateau.";
RL   Mol. Ecol. Resour. 19:1027-1036(2019).
CC   -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC       {ECO:0000256|ARBA:ARBA00004510}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAA0709372.1}.
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DR   EMBL; SOYY01000017; KAA0709372.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A5A9NH96; -.
DR   Proteomes; UP000324632; Chromosome 17.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030032; P:lamellipodium assembly; IEA:TreeGrafter.
DR   CDD; cd01225; PH_Cool_Pix; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd12061; SH3_betaPIX; 1.
DR   FunFam; 2.30.30.40:FF:000034; Rho guanine nucleotide exchange factor (GEF) 7; 1.
DR   FunFam; 1.20.900.10:FF:000016; Rho guanine nucleotide exchange factor 6; 1.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR035789; BetaPIX_SH3.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH_dom.
DR   InterPro; IPR032409; GEF6/7_CC.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR046376; PH_Cool_Pix.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR46026:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR   PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR   Pfam; PF16523; betaPIX_CC; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF16615; RhoGEF67_u1; 1.
DR   Pfam; PF16614; RhoGEF67_u2; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000324632};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          1..110
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          160..219
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          241..421
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          443..549
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          114..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        118..134
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   770 AA;  86318 MW;  9A1EA38641398105 CRC64;
     MNPEEQTVTW LITLGVLNSP KKNIADPEDF LKTSLKDGVV LCKLMERLLP GPILKYSSDP
     RCEADCIANI REFLKGCQSL KVEGFEPECL YTGENFGKVL STLTAVNIAT QDCTPKRSCP
     QSSTSAPSLS TVSQAVPTSQ SSRHLRRQSK AVEMSENGGG GHLLVKARFN FKQNNEDELS
     FNKGDLIHVS RQEDGGWWEG NLNGKTGWFP SNYVREVKPC DKPMSPKAMK GFDVPQLTKN
     YYSVVVQDIL EHEREFVKEL QTLLSCYLRP LPASDKLSNT DCSSLNGNLE DILSFQQGLC
     LALEECSKMS EGQQRIAGCY LNLMCQIRTL YLSYCSSHPS AVCVLTDHSE ELDKFMESQG
     ATAPGILTLT TSLSKPFMRL DKYPTLLQEL ERHVEEAHPD YSDVLKATSI FKNLVTQCQD
     LRKRKNLELQ ILSEPVRGWD GESMKSLGQV VYMSQVHMQS SSSEEKEERY FMLFPNAIVM
     LSASPRMSGF IYQGRLSLTG TTLTKQPEDT ETGYYAFEIT GGTLDRITVF CSSSQELQEW
     LEHLHAYTKE GSPVGTILKN VEGKSTTTPG AASHHLPGFG APVANRGPLE PPKVTKPWSL
     SCLRPAPPLK PSAALGYKED SSKSPRPIKK FFPMKKERKH SEDEFLLRKS TAALEEDAQI
     LKVIEAYCTG ASVHQTTTAV RKECIPQVLL PDEEKIIIEE MKSNGQTVIE EKSLVDAVYA
     LKDEVHELKK ENKWMKQCLE EEQKSRKELE RVVRKLAKQK NDCPWEEAGH
//
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