ID A0A5A9NH96_9TELE Unreviewed; 770 AA.
AC A0A5A9NH96;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 18-JUN-2025, entry version 17.
DE SubName: Full=Rho guanine nucleotide exchange factor 6 {ECO:0000313|EMBL:KAA0709372.1};
GN ORFNames=E1301_Tti004203 {ECO:0000313|EMBL:KAA0709372.1};
OS Triplophysa tibetana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Nemacheilidae; Triplophysa.
OX NCBI_TaxID=1572043 {ECO:0000313|EMBL:KAA0709372.1, ECO:0000313|Proteomes:UP000324632};
RN [1] {ECO:0000313|EMBL:KAA0709372.1, ECO:0000313|Proteomes:UP000324632}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TTIB1903HZAU {ECO:0000313|EMBL:KAA0709372.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAA0709372.1};
RX PubMed=30977968;
RA Yang X., Liu H., Ma Z., Zou Y., Zou M., Mao Y., Li X., Wang H., Chen T.,
RA Wang W., Yang R.;
RT "Chromosome-level genome assembly of Triplophysa tibetana, a fish adapted
RT to the harsh high-altitude environment of the Tibetan Plateau.";
RL Mol. Ecol. Resour. 19:1027-1036(2019).
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA0709372.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; SOYY01000017; KAA0709372.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5A9NH96; -.
DR Proteomes; UP000324632; Chromosome 17.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030032; P:lamellipodium assembly; IEA:TreeGrafter.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd12061; SH3_betaPIX; 1.
DR FunFam; 2.30.30.40:FF:000034; Rho guanine nucleotide exchange factor (GEF) 7; 1.
DR FunFam; 1.20.900.10:FF:000016; Rho guanine nucleotide exchange factor 6; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035789; BetaPIX_SH3.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH_dom.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16615; RhoGEF67_u1; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000324632};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..110
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 160..219
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 241..421
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 443..549
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 114..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..134
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 770 AA; 86318 MW; 9A1EA38641398105 CRC64;
MNPEEQTVTW LITLGVLNSP KKNIADPEDF LKTSLKDGVV LCKLMERLLP GPILKYSSDP
RCEADCIANI REFLKGCQSL KVEGFEPECL YTGENFGKVL STLTAVNIAT QDCTPKRSCP
QSSTSAPSLS TVSQAVPTSQ SSRHLRRQSK AVEMSENGGG GHLLVKARFN FKQNNEDELS
FNKGDLIHVS RQEDGGWWEG NLNGKTGWFP SNYVREVKPC DKPMSPKAMK GFDVPQLTKN
YYSVVVQDIL EHEREFVKEL QTLLSCYLRP LPASDKLSNT DCSSLNGNLE DILSFQQGLC
LALEECSKMS EGQQRIAGCY LNLMCQIRTL YLSYCSSHPS AVCVLTDHSE ELDKFMESQG
ATAPGILTLT TSLSKPFMRL DKYPTLLQEL ERHVEEAHPD YSDVLKATSI FKNLVTQCQD
LRKRKNLELQ ILSEPVRGWD GESMKSLGQV VYMSQVHMQS SSSEEKEERY FMLFPNAIVM
LSASPRMSGF IYQGRLSLTG TTLTKQPEDT ETGYYAFEIT GGTLDRITVF CSSSQELQEW
LEHLHAYTKE GSPVGTILKN VEGKSTTTPG AASHHLPGFG APVANRGPLE PPKVTKPWSL
SCLRPAPPLK PSAALGYKED SSKSPRPIKK FFPMKKERKH SEDEFLLRKS TAALEEDAQI
LKVIEAYCTG ASVHQTTTAV RKECIPQVLL PDEEKIIIEE MKSNGQTVIE EKSLVDAVYA
LKDEVHELKK ENKWMKQCLE EEQKSRKELE RVVRKLAKQK NDCPWEEAGH
//