ID A0A5A9NV45_9TELE Unreviewed; 245 AA.
AC A0A5A9NV45;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 18-JUN-2025, entry version 13.
DE RecName: Full=NFU1 iron-sulfur cluster scaffold homolog, mitochondrial {ECO:0000256|ARBA:ARBA00018782};
DE AltName: Full=HIRA-interacting protein 5 {ECO:0000256|ARBA:ARBA00076495};
GN ORFNames=E1301_Tti013371 {ECO:0000313|EMBL:KAA0713670.1};
OS Triplophysa tibetana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Nemacheilidae; Triplophysa.
OX NCBI_TaxID=1572043 {ECO:0000313|EMBL:KAA0713670.1, ECO:0000313|Proteomes:UP000324632};
RN [1] {ECO:0000313|EMBL:KAA0713670.1, ECO:0000313|Proteomes:UP000324632}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TTIB1903HZAU {ECO:0000313|EMBL:KAA0713670.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAA0713670.1};
RX PubMed=30977968;
RA Yang X., Liu H., Ma Z., Zou Y., Zou M., Mao Y., Li X., Wang H., Chen T.,
RA Wang W., Yang R.;
RT "Chromosome-level genome assembly of Triplophysa tibetana, a fish adapted
RT to the harsh high-altitude environment of the Tibetan Plateau.";
RL Mol. Ecol. Resour. 19:1027-1036(2019).
CC -!- FUNCTION: Iron-sulfur cluster scaffold protein which can assemble [4Fe-
CC 4S] clusters and deliver them to target proteins.
CC {ECO:0000256|ARBA:ARBA00057718}.
CC -!- SUBUNIT: Monomer and homohexamer; the apo-NFU1 is a monomer, while the
CC holo-NFU1 is a hexamer composed of a trimer of dimer that is probably
CC linked by some 4Fe-4S cluster. Interacts with HIRA and EPM2A/laforin.
CC Interacts with BOLA3. Interacts with HSPA9.
CC {ECO:0000256|ARBA:ARBA00062506}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the NifU family.
CC {ECO:0000256|ARBA:ARBA00006420}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA0713670.1}.
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DR EMBL; SOYY01000012; KAA0713670.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5A9NV45; -.
DR Proteomes; UP000324632; Chromosome 12.
DR GO; GO:0005739; C:mitochondrion; IEA:TreeGrafter.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR FunFam; 3.30.300.130:FF:000001; NFU1 iron-sulfur cluster scaffold; 1.
DR FunFam; 3.30.1370.70:FF:000002; NFU1 iron-sulfur cluster scaffold homolog, mitochondrial; 1.
DR Gene3D; 3.30.300.130; Fe-S cluster assembly (FSCA); 1.
DR Gene3D; 3.30.1370.70; Scaffold protein Nfu/NifU, N-terminal domain; 1.
DR InterPro; IPR034904; FSCA_dom_sf.
DR InterPro; IPR014824; Nfu/NifU_N.
DR InterPro; IPR036498; Nfu/NifU_N_sf.
DR InterPro; IPR035433; NFU1-like.
DR InterPro; IPR001075; NIF_FeS_clus_asmbl_NifU_C.
DR PANTHER; PTHR11178; IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED; 1.
DR PANTHER; PTHR11178:SF46; NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL; 1.
DR Pfam; PF08712; Nfu_N; 1.
DR Pfam; PF01106; NifU; 1.
DR PIRSF; PIRSF036773; HIRIP5; 1.
DR SMART; SM00932; Nfu_N; 1.
DR SUPFAM; SSF117916; Fe-S cluster assembly (FSCA) domain-like; 1.
DR SUPFAM; SSF110836; Hypothetical protein SAV1430; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00023014};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000324632};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 50..137
FT /note="Scaffold protein Nfu/NifU N-terminal"
FT /evidence="ECO:0000259|SMART:SM00932"
SQ SEQUENCE 245 AA; 27215 MW; 494D95BC39C577DB CRC64;
MAAYRSVGVG RNLVTLLTRS YHGLCKTPDI VKRIALPHQT TNMFIRNMFV QTQNTPNPNS
LKFIPGRVVL EAGTMDFTGP RDAYCSPLAR QLFRIDGVKS VLLGPDFITI TRVDGNTEWK
VIKPDVFATI MDFFTSGLPV VNEADVPSAD TAPSEEDDEV VAMIKELLDT RIRPTVQEDG
GDILYRGFED GIVMLKLQGA CTSCPSSIIT LKNGIQNMLQ FYVPEVEGVE QVKDEEVEVE
EKVKE
//