ID A0A5A9PX67_9TELE Unreviewed; 527 AA.
AC A0A5A9PX67;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 05-FEB-2025, entry version 16.
DE SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|EMBL:KAA0725176.1};
GN ORFNames=E1301_Tti005888 {ECO:0000313|EMBL:KAA0725176.1};
OS Triplophysa tibetana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Nemacheilidae; Triplophysa.
OX NCBI_TaxID=1572043 {ECO:0000313|EMBL:KAA0725176.1, ECO:0000313|Proteomes:UP000324632};
RN [1] {ECO:0000313|EMBL:KAA0725176.1, ECO:0000313|Proteomes:UP000324632}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TTIB1903HZAU {ECO:0000313|EMBL:KAA0725176.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAA0725176.1};
RX PubMed=30977968;
RA Yang X., Liu H., Ma Z., Zou Y., Zou M., Mao Y., Li X., Wang H., Chen T.,
RA Wang W., Yang R.;
RT "Chromosome-level genome assembly of Triplophysa tibetana, a fish adapted
RT to the harsh high-altitude environment of the Tibetan Plateau.";
RL Mol. Ecol. Resour. 19:1027-1036(2019).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA0725176.1}.
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DR EMBL; SOYY01000001; KAA0725176.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5A9PX67; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000324632; Chromosome 1.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000324632};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 372..467
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 462..511
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 97..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..115
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 527 AA; 58838 MW; 9B7D843B594B4AA3 CRC64;
MEKVGKVWSN LKRGCQSLLH PEEGGSRVEA PQQLESNTDT VCHSVNRALV ENMFEAAGTS
SSEAALPLVS WRTSGGVSRR GHNCVADVPQ ILEITVEQDN EDTRAPLGAR RDSYSRHAPW
SGKKRHSCST KAQSSLEITE RRSGRSQRRH GTGSSREDIE PGTGRSLRQQ IHDTVGLCLP
LRSSSRSNHL PHPKRKIQIT ELMLDTCPFA PGSDLARKWH LIKQHTTAVN GMQVDPSSDA
CGATCASPED EEERLRERRR LSIEEGVEPP PDAHIHTVDA ITPPLASLYK LGPKLPPGMG
ESLSGGATAV NCDSEDDDTT TLCLQTRRPK QRHSSVEGHL GGKQTGPWKI HTQIDYIHCL
VPDQQQITAL PCYWGVMDRY EAEALLDGRP EGTFLLRDSA QDDYLFSVSF RRYGRSLHAR
IEQWNHNFSF DAHDPCVFHA ATITALLEHY KDPSACMFFE PLLTVPLSRT FPFALQSLAR
GSICHGITYD GIGALSLPPA LQDYLREYHY KQRVRVRWLE REPIKAK
//
