ID A0A5B0R898_PUCGR Unreviewed; 366 AA.
AC A0A5B0R898;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 05-FEB-2025, entry version 16.
DE RecName: Full=2-dehydropantoate 2-reductase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PGT21_035552 {ECO:0000313|EMBL:KAA1095100.1}, PGTUg99_015709
GN {ECO:0000313|EMBL:KAA1121363.1};
OS Puccinia graminis f. sp. tritici.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Pucciniomycetes; Pucciniales; Pucciniaceae; Puccinia.
OX NCBI_TaxID=56615 {ECO:0000313|EMBL:KAA1121363.1, ECO:0000313|Proteomes:UP000325313};
RN [1] {ECO:0000313|Proteomes:UP000324748, ECO:0000313|Proteomes:UP000325313}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=21-0 {ECO:0000313|EMBL:KAA1095100.1}, and Ug99
RC {ECO:0000313|EMBL:KAA1121363.1, ECO:0000313|Proteomes:UP000325313};
RA Li F., Upadhyaya N.M., Sperschneider J., Matny O., Nguyen-Phuc H., Mago R.,
RA Raley C., Miller M.E., Silverstein K.A.T., Henningsen E., Hirsch C.D.,
RA Visser B., Pretorius Z.A., Steffenson B.J., Schwessinger B., Dodds P.N.,
RA Figueroa M.;
RT "Emergence of the Ug99 lineage of the wheat stem rust pathogen through
RT somatic hybridization.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA1121363.1}.
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DR EMBL; VSWC01000079; KAA1095100.1; -; Genomic_DNA.
DR EMBL; VDEP01000238; KAA1121363.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5B0R898; -.
DR OrthoDB; 3609at2759; -.
DR Proteomes; UP000324748; Unassembled WGS sequence.
DR Proteomes; UP000325313; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:InterPro.
DR GO; GO:0015940; P:pantothenate biosynthetic process; IEA:InterPro.
DR FunFam; 1.10.1040.10:FF:000017; 2-dehydropantoate 2-reductase; 1.
DR FunFam; 3.40.50.720:FF:000609; 2-dehydropantoate 2-reductase; 1.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR003710; ApbA.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR051402; KPR-Related.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR00745; apbA_panE; 1.
DR PANTHER; PTHR21708:SF26; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Reference proteome {ECO:0000313|Proteomes:UP000324748}.
FT DOMAIN 7..173
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 223..351
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 366 AA; 40979 MW; 5A37DFA4586E7A87 CRC64;
MASDIRILIV GAGAVGAFYG SRLHRPEQGV KVSFICRSNY EEVKANGMEI ESRTFGRYRI
RPEQVFKSID EAAELGGSGT GRRWDYVILC TKVLPDRVDD SALLSPLLAV ADHDDRPPPT
LVLIQNGIGF EDNHRQRHPK VPILSAVTVV NAEQLKPSLV RHNRWTRISI GPYLNFSSYL
EHPHPPIDPQ LEAHSQSQLK LLVEFLRNGQ INDAEIYGEK DLQILRWHKL AINASMNPTS
ILSGGLPSSE MVKSPQLRSH LEGCMEEIFE AAAKIFKIER FPAKFASIER ILESTQRAGE
QSTIKPSMLV DWELGRPLEI EAILGLPIRI AARAGVKLAR IQSMYAFLTQ LQLARSQKNG
LNQARI
//
