ID A0A5B7E777_PORTR Unreviewed; 1046 AA.
AC A0A5B7E777;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE SubName: Full=Superkiller viralicidic activity 2-like 2 {ECO:0000313|EMBL:MPC29872.1};
GN Name=SKIV2L2 {ECO:0000313|EMBL:MPC29872.1};
GN ORFNames=E2C01_023124 {ECO:0000313|EMBL:MPC29872.1};
OS Portunus trituberculatus (Swimming crab) (Neptunus trituberculatus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC Eubrachyura; Portunoidea; Portunidae; Portuninae; Portunus.
OX NCBI_TaxID=210409 {ECO:0000313|EMBL:MPC29872.1, ECO:0000313|Proteomes:UP000324222};
RN [1] {ECO:0000313|EMBL:MPC29872.1, ECO:0000313|Proteomes:UP000324222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Muscle {ECO:0000313|EMBL:MPC29872.1};
RA Jeong J.-H., Song I., Kim S., Choi T., Kim D., Ryu S., Kim W.;
RT "Another draft genome of Portunus trituberculatus and its Hox gene families
RT provides insights of decapod evolution.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MPC29872.1}.
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DR EMBL; VSRR010002152; MPC29872.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5B7E777; -.
DR OrthoDB; 64767at2759; -.
DR Proteomes; UP000324222; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0000460; P:maturation of 5.8S rRNA; IEA:TreeGrafter.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18024; DEXHc_Mtr4-like; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR FunFam; 3.40.50.300:FF:000083; ATP-dependent RNA helicase DOB1; 1.
DR FunFam; 3.40.50.300:FF:000141; ATP-dependent RNA helicase DOB1; 1.
DR FunFam; 2.40.30.300:FF:000001; Mtr4 exosome RNA helicase; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 2.40.30.300; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR025696; Beta-barrel_MTR4.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C-like.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR050699; RNA-DNA_Helicase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000324222}.
FT DOMAIN 132..288
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 358..559
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 44..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 805..832
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 48..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1046 AA; 119593 MW; B6835DF6CA40464F CRC64;
MACFGDDLFD FVENEGDTQV QVLPDTEEVS TYESEKAAEE LNLLLGKRTN EDDSKSEKKN
KKLRSQVEAA ESELRLTEEM PRISIHTIES VEACTHEVAV PPGELYVPLK PPKEKPARTY
PFILDPFQKE AILCIDNNQS VLVSAHTSAG KTVVGEYAIA MCLQNKQRVI YTTPIKALSN
QKYRDFCDEF TDVGLLTGDV TINPNASCLI MTTEILRSML YRGSEVTREV GWVIFDEIHY
MRDKERGYVW EETIILLPPT VHFVFLSATI PNASQFAQWI CHLHHQPCHV VYTDYRPTPL
QHYIFPAGGE GIYLAVDETG KFREDNFNTA MTVLQNAPEQ GNLRGKKGGV KEGSDCFKLV
KMIMERNFAP VIIFSFSKKE CEAYALQMSK LDFNLAEEKK LVDEVFQNAI GVLSEEDKQL
PQVVSVLPLL RRGIGIHHGG LLPIIKETIE ILFGEGLVKA LFATETFAMG LNMPARTVLF
TSVRKFDGHD FRWLTSGEYI QMSGRAGRRG KDDKGIVIMM VDEKLNTSVV KNLVQGKADP
INSAFHLTYN MVLNLLRVEQ INPEYILERS FFQFQNYSSI PELCDRVRKY DKDLGEVFVP
RENEVESYFT IKQTIQNLQM ERHVFITRPI YIMPFLQPGR LVYIKNNNDD FGWGVVLSYK
KQEDKKNPTE APTITVDVIL RVSEATAASK VVSEVKPAQA GEKSEPVIMA VALKCVQEVS
AVRLKLPSDL KPLDQRIMVI KMIQEAVKRV PESQFLLDPV KNMKIKEDVF LEIVNKLEKF
KTRLESHKLH RDPERDMLYE KYAKKMELKK ELNNAELDLK KARSLLQMDE LKCRKRVLRR
LGYATSQDVI ERKGRVACEL SAADELLITE MLFNGLFNNL SASQTCALLS TFVCDEKSSE
MPKLGEELSG PLRQMQDIAR RIARVSHECK LEIDESNYVE QFKPFLMDIV YEWCNGSIIR
AMRRLEELLR QMIQAAKAIG IDLENKFSEG IKLLKRDIVF AANKRTKESN EDRLCYQRAQ
PTEYADLSLT ARFVKCEKLL MHTKRC
//
