ID A0A5C1QBF5_9SPIO Unreviewed; 687 AA.
AC A0A5C1QBF5;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 08-OCT-2025, entry version 20.
DE RecName: Full=Chemotaxis protein CheA {ECO:0000256|ARBA:ARBA00021495};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=EW093_04525 {ECO:0000313|EMBL:QEN03994.1};
OS Thiospirochaeta perfilievii.
OC Bacteria; Pseudomonadati; Spirochaetota; Spirochaetia; Spirochaetales;
OC Spirochaetaceae; Thiospirochaeta.
OX NCBI_TaxID=252967 {ECO:0000313|EMBL:QEN03994.1, ECO:0000313|Proteomes:UP000323824};
RN [1] {ECO:0000313|EMBL:QEN03994.1, ECO:0000313|Proteomes:UP000323824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P {ECO:0000313|EMBL:QEN03994.1,
RC ECO:0000313|Proteomes:UP000323824};
RA Fomenkov A., Dubinina G., Grabovich M., Vincze T., Roberts R.J.;
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QEN03994.1, ECO:0000313|Proteomes:UP000323824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P {ECO:0000313|EMBL:QEN03994.1,
RC ECO:0000313|Proteomes:UP000323824};
RA Leshcheva N., Mikheeva N.;
RT "Complete Genome Sequence and Methylome Analysis of free living
RT Spirochaetas.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the transmission of sensory signals from the
CC chemoreceptors to the flagellar motors. CheA is autophosphorylated; it
CC can transfer its phosphate group to either CheB or CheY.
CC {ECO:0000256|ARBA:ARBA00035100}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP035807; QEN03994.1; -; Genomic_DNA.
DR RefSeq; WP_149567251.1; NZ_CP035807.1.
DR AlphaFoldDB; A0A5C1QBF5; -.
DR KEGG; sper:EW093_04525; -.
DR OrthoDB; 9803176at2; -.
DR Proteomes; UP000323824; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR CDD; cd00731; CheA_reg; 1.
DR CDD; cd16916; HATPase_CheA-like; 1.
DR CDD; cd00088; HPT; 1.
DR FunFam; 2.30.30.40:FF:000048; Chemotaxis protein CheA, putative; 1.
DR FunFam; 3.30.565.10:FF:000016; Chemotaxis protein CheA, putative; 1.
DR Gene3D; 1.10.287.560; Histidine kinase CheA-like, homodimeric domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.20.120.160; HPT domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR051315; Bact_Chemotaxis_CheA.
DR InterPro; IPR004105; CheA-like_dim.
DR InterPro; IPR037006; CheA-like_homodim_sf.
DR InterPro; IPR036061; CheW-like_dom_sf.
DR InterPro; IPR002545; CheW-lke_dom.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR003594; HATPase_dom.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR036641; HPT_dom_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR008207; Sig_transdc_His_kin_Hpt_dom.
DR InterPro; IPR037257; T2SS_E_N_sf.
DR PANTHER; PTHR43395:SF10; CHEMOTAXIS PROTEIN CHEA; 1.
DR PANTHER; PTHR43395; SENSOR HISTIDINE KINASE CHEA; 1.
DR Pfam; PF01584; CheW; 1.
DR Pfam; PF02895; H-kinase_dim; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF01627; Hpt; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00260; CheW; 1.
DR SMART; SM01231; H-kinase_dim; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00073; HPT; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF50341; CheW-like; 1.
DR SUPFAM; SSF160246; EspE N-terminal domain-like; 1.
DR SUPFAM; SSF47226; Histidine-containing phosphotransfer domain, HPT domain; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50851; CHEW; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50894; HPT; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chemotaxis {ECO:0000256|ARBA:ARBA00022500};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00110}; Reference proteome {ECO:0000313|Proteomes:UP000323824};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 1..103
FT /note="HPt"
FT /evidence="ECO:0000259|PROSITE:PS50894"
FT DOMAIN 269..545
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 547..679
FT /note="CheW-like"
FT /evidence="ECO:0000259|PROSITE:PS50851"
FT MOD_RES 46
FT /note="Phosphohistidine"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00110"
SQ SEQUENCE 687 AA; 76897 MW; 656A4286EA5368CE CRC64;
MEDDNFIKIF KEEALELLGH LEDSLLELES SPDDEDLISA VFRVMHTVKG SAGMVGLDLI
SKFTHEVESI LESVRSGDIK VSKGFIDYTL RSRDIILSMI NDPEYRIDDQ EAFFVDFKNA
LNENYISPDD NKESITYRVI FKPEPKMFFT GTNPLMMVHE VLELGDGLVI PYYEKIPKLS
NLNTEECYVY WEIYITTQKS VNKIHDIFIF VDAPSEVTIE EWELNSEEPI PEKLGDLLVK
RGSLKKEELD KALKEQHKLG EILVKESMLS EHEIKNALKA QTYINKTKTK KIEAAAPAND
SIRINSNKLD SLIDLVGEIV TIYAQMLQLS HDTNDSKLIS IIERFGLLTE ELRDNSMSMR
MLPIGSTFSR FRRLVRDLSS ELGKKIELVT EGAETELDKN VIEQLHDPLV HIIRNCIDHG
IESPTVRKAN GKDETGTIKL SAIHAGASVQ IVIQDDGGGL NREKIRSKGI ARGLIRDGEE
ILDDDLFNLI FAPGFSTAAS ITNVSGRGVG LDVVKKQIEE LKGSVAITSE EGKYTRITLT
LPITLAIIEG LLVNIGGDSY VIPLSTVEAC VELKEENKDH KSGKNVITFR EKLVPYIDLR
TFFEVEGRRR DIEQIVIVNS NSSQIGLLVD NVIGGNQTVI KSLGSMYRHI KEISGAAILG
DGSVALVFDI EQLVRVVQDF EEISVGN
//
