ID A0A5C3PKB8_9APHY Unreviewed; 543 AA.
AC A0A5C3PKB8;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 02-APR-2025, entry version 17.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN ORFNames=K466DRAFT_550427 {ECO:0000313|EMBL:TFK86413.1};
OS Polyporus arcularius HHB13444.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Polyporaceae; Polyporus.
OX NCBI_TaxID=1314778 {ECO:0000313|EMBL:TFK86413.1, ECO:0000313|Proteomes:UP000308197};
RN [1] {ECO:0000313|EMBL:TFK86413.1, ECO:0000313|Proteomes:UP000308197}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HHB13444 {ECO:0000313|EMBL:TFK86413.1,
RC ECO:0000313|Proteomes:UP000308197};
RX PubMed=30886374; DOI=.1038/s41559-019-0834-1;
RA Varga T., Krizsan K., Foldi C., Dima B., Sanchez-Garcia M.,
RA Sanchez-Ramirez S., Szollosi G.J., Szarkandi J.G., Papp V., Albert L.,
RA Andreopoulos W., Angelini C., Antonin V., Barry K.W., Bougher N.L.,
RA Buchanan P., Buyck B., Bense V., Catcheside P., Chovatia M., Cooper J.,
RA Damon W., Desjardin D., Finy P., Geml J., Haridas S., Hughes K., Justo A.,
RA Karasinski D., Kautmanova I., Kiss B., Kocsube S., Kotiranta H.,
RA LaButti K.M., Lechner B.E., Liimatainen K., Lipzen A., Lukacs Z.,
RA Mihaltcheva S., Morgado L.N., Niskanen T., Noordeloos M.E., Ohm R.A.,
RA Ortiz-Santana B., Ovrebo C., Racz N., Riley R., Savchenko A., Shiryaev A.,
RA Soop K., Spirin V., Szebenyi C., Tomsovsky M., Tulloss R.E., Uehling J.,
RA Grigoriev I.V., Vagvolgyi C., Papp T., Martin F.M., Miettinen O.,
RA Hibbett D.S., Nagy L.G.;
RT "Megaphylogeny resolves global patterns of mushroom evolution.";
RL Nat. Ecol. Evol. 3:668-678(2019).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
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DR EMBL; ML211200; TFK86413.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5C3PKB8; -.
DR STRING; 1314778.A0A5C3PKB8; -.
DR InParanoid; A0A5C3PKB8; -.
DR Proteomes; UP000308197; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd22584; Rcat_RBR_unk; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF01485; IBR; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS51873; TRIAD; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000308197};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 108..309
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..45
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..463
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..482
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 543 AA; 59319 MW; F126701838288F59 CRC64;
MQMDEDQPRV QPAQLNAIPG PSVARPALTP TQGPAAARNA ATFARPPNPG LANPPGRTAA
PSNPPPTGGG WGFLTSVWDW WFGPSVPAAT ISIPPPPPTR RPIAAQQNRL TGHNCVSCMD
PIRGVEVGTP CGHHYDKTCI LGLFEAAIKD ESLFPPRCCR LPIPLRSVSS YMSADSVLKF
TDKTVEFRTR KRVYCARPSC SRFLGKQYEG ELAHIRAPRL ECPVPGCGMV TCSSCKSEAK
WGLRHRCQAD EADAPILALG QQSGWARCPG CETMIELNMG CYHMTCRCRT EFCYLCRARW
KTCPCPQWDE QRLLVAAQAR ADAQIRFGAA QPQVRVHREP AAPAAPRAPV PVRAPPLPAA
PARVAPVPAA PQAPARRDLM TAELPGVHPP ARASQAATRV PDAAGTIART HTIRLRQAPA
VSASSSATGS TLASRTRPAA VPSASSSSSN WRSSVVRPSG SSRTTAATRE QTEVEPSKKR
ERQDLVQQWV ERLRVNHDCN HDAWKYRRGE GSCEVCHDHL RLYLFRCNGC ELMACRRCRW
NRL
//
