ID A0A5C3Q1B9_9AGAR Unreviewed; 893 AA.
AC A0A5C3Q1B9;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 18-JUN-2025, entry version 22.
DE RecName: Full=Phospholipase {ECO:0000256|PIRNR:PIRNR009376};
DE EC=3.1.4.4 {ECO:0000256|PIRNR:PIRNR009376};
GN ORFNames=BDV98DRAFT_608823 {ECO:0000313|EMBL:TFK95611.1};
OS Pterulicium gracile.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Pleurotineae; Pterulaceae; Pterula.
OX NCBI_TaxID=1884261 {ECO:0000313|EMBL:TFK95611.1, ECO:0000313|Proteomes:UP000305067};
RN [1] {ECO:0000313|EMBL:TFK95611.1, ECO:0000313|Proteomes:UP000305067}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 309.79 {ECO:0000313|EMBL:TFK95611.1,
RC ECO:0000313|Proteomes:UP000305067};
RX PubMed=30886374; DOI=.1038/s41559-019-0834-1;
RA Varga T., Krizsan K., Foldi C., Dima B., Sanchez-Garcia M.,
RA Sanchez-Ramirez S., Szollosi G.J., Szarkandi J.G., Papp V., Albert L.,
RA Andreopoulos W., Angelini C., Antonin V., Barry K.W., Bougher N.L.,
RA Buchanan P., Buyck B., Bense V., Catcheside P., Chovatia M., Cooper J.,
RA Damon W., Desjardin D., Finy P., Geml J., Haridas S., Hughes K., Justo A.,
RA Karasinski D., Kautmanova I., Kiss B., Kocsube S., Kotiranta H.,
RA LaButti K.M., Lechner B.E., Liimatainen K., Lipzen A., Lukacs Z.,
RA Mihaltcheva S., Morgado L.N., Niskanen T., Noordeloos M.E., Ohm R.A.,
RA Ortiz-Santana B., Ovrebo C., Racz N., Riley R., Savchenko A., Shiryaev A.,
RA Soop K., Spirin V., Szebenyi C., Tomsovsky M., Tulloss R.E., Uehling J.,
RA Grigoriev I.V., Vagvolgyi C., Papp T., Martin F.M., Miettinen O.,
RA Hibbett D.S., Nagy L.G.;
RT "Megaphylogeny resolves global patterns of mushroom evolution.";
RL Nat. Ecol. Evol. 3:668-678(2019).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-
CC sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:14445,
CC ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58608; EC=3.1.4.4;
CC Evidence={ECO:0000256|PIRNR:PIRNR009376};
CC -!- SIMILARITY: Belongs to the phospholipase D family.
CC {ECO:0000256|PIRNR:PIRNR009376}.
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DR EMBL; ML178879; TFK95611.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5C3Q1B9; -.
DR STRING; 1884261.A0A5C3Q1B9; -.
DR OrthoDB; 14911at2759; -.
DR Proteomes; UP000305067; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:TreeGrafter.
DR GO; GO:0004630; F:phospholipase D activity; IEA:UniProtKB-UniRule.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0006654; P:phosphatidic acid biosynthetic process; IEA:InterPro.
DR GO; GO:0009395; P:phospholipid catabolic process; IEA:TreeGrafter.
DR CDD; cd00138; PLDc_SF; 1.
DR CDD; cd09138; PLDc_vPLD1_2_yPLD_like_1; 1.
DR CDD; cd09141; PLDc_vPLD1_2_yPLD_like_2; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 3.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR InterPro; IPR016555; PLipase_D_euk.
DR InterPro; IPR015679; PLipase_D_fam.
DR PANTHER; PTHR18896; PHOSPHOLIPASE D; 1.
DR PANTHER; PTHR18896:SF186; PHOSPHOLIPASE D; 1.
DR Pfam; PF00614; PLDc; 1.
DR Pfam; PF13091; PLDc_2; 1.
DR PIRSF; PIRSF009376; Phospholipase_D_euk; 2.
DR SMART; SM00155; PLDc; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR009376};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963,
KW ECO:0000256|PIRNR:PIRNR009376};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000305067}.
FT DOMAIN 181..208
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 678..705
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT REGION 338..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 893 AA; 103066 MW; 6C70AA0454769AC4 CRC64;
MSFFKNLKNK VEQAADKLPQ GLMNARAEAI GLWNPNRRHD EPHEIENDRV REDIMQGHRF
RSFANERNDN TVKWHIDGHD YMWAMSELLD KAKEAIFILD WWLTPELFLR RPPARHPEWR
LDRLLKRKAE EGVKVYVIVY KEVTQTMSMS SKHTKNYLEG LHPNIVCLRH PDHVGSKDSV
QFWSHHEKVV VVDNHYACIG GLDLCFGRWD THNHPCADCH PTDFSKTLFP GQDYNNARVM
DFQNVFNYAS NAISVLESPR MPWHDVHMTL TGPVVLDIVQ HFVERWNEIK KRKYRDKENV
DWLSLPHNVQ ASPNEAVARH PHRDEWQNKG RRFKQRFHFS SEEEQEEHRN SEYHGGRDRR
DEGEDRDGDR YRDGERDGDR YRGGDRDGER RSAREGTCRV QVVRSVSDWS HGVLTECSIQ
NAYVESIRDA RHYIYIENQF FITATKTGGQ VVNQIGKALV DRIVQAAQNR EKFKVVVVIP
EVPGFAGDVK TESSIKYIMA AQYRSINRGG DSIYEQIRRA GYEPLDYIRF YHLRSYDRIN
APMPTFINQM EENSGVRFHE AQVALSRLLI GTSQTDQREV TLAVPEPMMH GLVEGGTAGH
KTGEGNTQKP NTITIPIPES EDAAREIIER FERGAEGVRG DEEVSDSVAQ HMLGDRTGLK
DEKWLGTEEE ELKSYVSELL YIHTKLMIVD DARVIMGSAN INDRSQKGDG DSEIALVVED
MDLIDATMGG QHVMVSRFAS SLRRKLYREH IGLIEPQNCG IANDRVTSFM RAAPHANKDE
FDEEEDRLVA DPLADDTWRL WNETAKRNTQ IFTELFRPVP TNLVRDWGAY DNYVAKVKPG
HVVEGISLET VKDRLSEVKG ALIECPLDFL IDQRDFVEGP EWRGFDPTLP IYI
//
