ID A0A5C6MJK6_9TELE Unreviewed; 923 AA.
AC A0A5C6MJK6;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 28-JAN-2026, entry version 26.
DE RecName: Full=Platelet-derived growth factor receptor-like protein {ECO:0000256|ARBA:ARBA00019671};
GN ORFNames=D4764_09G0000080 {ECO:0000313|EMBL:TWW54959.1};
OS Takifugu flavidus (sansaifugu).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=433684 {ECO:0000313|EMBL:TWW54959.1, ECO:0000313|Proteomes:UP000324091};
RN [1] {ECO:0000313|EMBL:TWW54959.1, ECO:0000313|Proteomes:UP000324091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTHZ2018 {ECO:0000313|EMBL:TWW54959.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TWW54959.1};
RA Xiao S.;
RT "Chromosome genome assembly for Takifugu flavidus.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Forms a complex composed of PDGFRL, TNK2 and GRB2.
CC {ECO:0000256|ARBA:ARBA00011360}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TWW54959.1}.
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DR EMBL; RHFK02000022; TWW54959.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5C6MJK6; -.
DR Proteomes; UP000324091; Chromosome 9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR042495; PDGFRL.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR15360; PLATELET-DERIVED GROWTH FACTOR RECEPTOR LIKE; 1.
DR PANTHER; PTHR15360:SF4; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF25305; Ig_PDGFR_d4; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PIRSF; PIRSF000615; TyrPK_CSF1-R; 1.
DR PRINTS; PR01832; VEGFRECEPTOR.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:TWW54959.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000324091};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 551..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..136
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 239..332
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 859..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 870..879
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 923 AA; 103463 MW; 522A48068630E962 CRC64;
MFRRLGREVH RLLPPVDLCL SFLAGSSMLR ASAMRAAVLH LTVALAALLS SCTTVSCLKI
VPEEKQLILA EGSSLSLTCA GSSETTWDLK SDDVPFFQMK AESSGLNYKI VQSNSTASVL
TLWHVDWKNT GVYQCREQLT GEIKEVAVFV PDPEVWFIES SHGMVTKTSG ESTVPCVVTN
PNIMVTLYDK DTDLPVNGVY VPSEGFKAYL DYRTYVCRGE LNGVVKESQA FNVYSIHVPE
DIDAYVNASQ TVLKQGEPLT VNCTVQGVEL VLFSWDIPNR DIVKHKPETV VLSATTMRSC
LVFPHATVAH SGTYVCHAHE STQDQKAFAS VNITVLERGF VAVKSTQKQN ITAELQENVE
LRVEIEAYPP PQIRWKKDGA PVRGDKTIII RQEHEIRYVT ILTLVRVRTE QKGLYTALIT
NEDDVKEVTF ALEVQVLARI KDLTDHHLPG KKQLVTCVAE GVPTPTIQWY SCDSMLKCNN
QTSLWQQLKA DPELLSIHTS VTEARRTNQV QSQVTFFKPQ HTTVRCETTN QEGLIDFRDV
KLVSSSLFSQ VVLLAVVLTL VPIIIMSIII LIAVWKKAKG RYRPLYLVTE YCRYGDLVDY
LHRNKHTFLQ YYLDKNQDDG SLISGGSTPL SQRKGYVSFG SESDGGYMDM SKDEPAVYVP
MQEQMDTIKY ADIQPSPYES PYQQDLYQEQ GGGRVDLVIS DSPALTYDDL LGFSYQVAKG
MEFLASKNAT VYYKAVKIKL TIPPLYEIMK RCWDETFEKR PDFSFLVHCV GDMLTDSYKK
KYSQVNETFL KSDHPAVART KPRLSSPFPI ANPAFGSPSL VGLSDFPDPY NQNTRHFRNE
AEVQEGVTSF NEYIIPIPDP KPEEAFTDVP SESPESSLAL EEETDSVHDS TDTLPEEDRL
EETSERDALL GSSGTPEVED SFL
//
