ID A0A5C6NUU0_9TELE Unreviewed; 845 AA.
AC A0A5C6NUU0;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 18-JUN-2025, entry version 22.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN ORFNames=D4764_18G0001830 {ECO:0000313|EMBL:TWW69377.1};
OS Takifugu flavidus (sansaifugu).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=433684 {ECO:0000313|EMBL:TWW69377.1, ECO:0000313|Proteomes:UP000324091};
RN [1] {ECO:0000313|EMBL:TWW69377.1, ECO:0000313|Proteomes:UP000324091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTHZ2018 {ECO:0000313|EMBL:TWW69377.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TWW69377.1};
RA Xiao S.;
RT "Chromosome genome assembly for Takifugu flavidus.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Endoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004586}.
CC -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000256|ARBA:ARBA00008842,
CC ECO:0000256|RuleBase:RU003844}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TWW69377.1}.
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DR EMBL; RHFK02000010; TWW69377.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5C6NUU0; -.
DR Proteomes; UP000324091; Chromosome 18.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0031965; C:nuclear membrane; IEA:TreeGrafter.
DR GO; GO:0097038; C:perinuclear endoplasmic reticulum; IEA:TreeGrafter.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0015485; F:cholesterol binding; IEA:TreeGrafter.
DR GO; GO:0005319; F:lipid transporter activity; IEA:UniProtKB-ARBA.
DR FunFam; 2.30.29.30:FF:000011; Oxysterol-binding protein; 1.
DR FunFam; 2.40.160.120:FF:000001; Oxysterol-binding protein; 1.
DR FunFam; 3.30.70.3490:FF:000002; Oxysterol-binding protein; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972:SF146; OXYSTEROL-BINDING PROTEIN; 1.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000324091};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 84..204
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 845 AA; 96292 MW; 6BF98BF581A8627C CRC64;
MHRFSCPSTM MDPQVCPPPL SSNQSMVSSM EKSPGSTFKP GHSRSNSTGS IRNSKQSNNW
EVMNDLHQMD ICTGPGSSID LSIPGICEGY LMKRRKYPLK GWHKRYFLLE KGILKYSKTQ
QDIQRGKLHG SLDISSAVLS INKKAKRIDL DAGDNLYHIK PLKYVTSASL YQQQDGSPAL
TASAQTGVKS KVSAWLQQTH DIDATSNELA RCQLELTELA QLIQRLHWLE GGLPITSTDL
EMRISMHNLT LKKPKKKTGK VFGHSRTLSR VEDLGVMFTS SHLSTSNSAS VKSIPDYVYS
QLSSPHVTSP EAKKLHQEIY GVSQRVHASL KSVHDVLTLE RERVRQAWTG PDLRQNTSEQ
LATLCSTLTE LDIQSRLTKV HSLSLSSDST DESFCTVRPD QRTPSLSRHS HRPPSVADSM
AEYFDASDVI PYETLSEAEA SDESGLSDIT TTSNSEPDEG HGRRTTLPAP GQDNSHIGIM
TILYNNIGKD LSRVSMPVAL NEPVSLLQRL SEELEYTDLL DIANHIDDPY ERMVYVAVFS
ISGYAWASWR YRYKPFNPVL GETYESHRED RGFHYVSEQV SHHPPISACH AQSENFTFWQ
DQRWKNKFWG KSVEIISSGL VNVTLPRYGD HYEWNKAVTC IHNVLNQQQR WLEHYGEVVI
RNKDSDVCTC KITFVKSRYW SSDNSKNEVQ GVVLNRAGEV VHRFGGLWHE GIFCDTLPTP
KCIWKPNEQP EDFFDYYGFS TYARELNELT PELEAVLPPT DTRFRPDQRL LEQGKVEEAD
KKKDEVEEKQ RERRKEMAKK GEEHVPRFFR KEVDQAGKEV WLYKGTYWQL RRDPGFANTD
NLHLW
//
