ID A0A5C7EYW1_9PROT Unreviewed; 149 AA.
AC A0A5C7EYW1;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE RecName: Full=Mercuric resistance operon regulatory protein {ECO:0000256|ARBA:ARBA00017146};
GN Name=merR {ECO:0000313|EMBL:TXF12282.1};
GN ORFNames=FR698_07095 {ECO:0000313|EMBL:TXF12282.1};
OS Pelomicrobium methylotrophicum.
OC Bacteria; Pseudomonadati; Pseudomonadota; Hydrogenophilia;
OC Hydrogenophilia incertae sedis; Pelomicrobium.
OX NCBI_TaxID=2602750 {ECO:0000313|EMBL:TXF12282.1, ECO:0000313|Proteomes:UP000321201};
RN [1] {ECO:0000313|EMBL:TXF12282.1, ECO:0000313|Proteomes:UP000321201}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SM250 {ECO:0000313|EMBL:TXF12282.1,
RC ECO:0000313|Proteomes:UP000321201};
RA Slobodkina G.B., Merkel A.Y., Slobodkin A.I.;
RT "Pelomicrobium methylotrophicum gen. nov., sp. nov. a moderately
RT thermophilic, facultatively anaerobic, lithoautotrophic and methylotrophic
RT bacterium isolated from a terrestrial mud volcano.";
RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the mercuric-dependent induction of mercury
CC resistance operon. In the absence of mercury MerR represses
CC transcription by binding tightly to the mer operator region; when
CC mercury is present the dimeric complex binds a single ion and becomes a
CC potent transcriptional activator, while remaining bound to the mer
CC site. {ECO:0000256|ARBA:ARBA00024874}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TXF12282.1}.
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DR EMBL; VPFL01000007; TXF12282.1; -; Genomic_DNA.
DR RefSeq; WP_147799481.1; NZ_VPFL01000007.1.
DR AlphaFoldDB; A0A5C7EYW1; -.
DR InParanoid; A0A5C7EYW1; -.
DR OrthoDB; 5297305at2; -.
DR Proteomes; UP000321201; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0045340; F:mercury ion binding; IEA:InterPro.
DR GO; GO:0046689; P:response to mercury ion; IEA:UniProtKB-KW.
DR CDD; cd04783; HTH_MerR1; 1.
DR Gene3D; 1.10.1660.10; -; 1.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR011794; MerR.
DR InterPro; IPR000551; MerR-type_HTH_dom.
DR InterPro; IPR047057; MerR_fam.
DR InterPro; IPR015358; Tscrpt_reg_MerR_DNA-bd.
DR NCBIfam; TIGR02051; MerR; 1.
DR PANTHER; PTHR30204:SF69; MERR-FAMILY TRANSCRIPTIONAL REGULATOR; 1.
DR PANTHER; PTHR30204; REDOX-CYCLING DRUG-SENSING TRANSCRIPTIONAL ACTIVATOR SOXR; 1.
DR Pfam; PF00376; MerR; 1.
DR Pfam; PF09278; MerR-DNA-bind; 1.
DR PRINTS; PR00040; HTHMERR.
DR SMART; SM00422; HTH_MERR; 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR PROSITE; PS50937; HTH_MERR_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Mercuric resistance {ECO:0000256|ARBA:ARBA00022466};
KW Mercury {ECO:0000256|ARBA:ARBA00022914};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000321201};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 12..81
FT /note="HTH merR-type"
FT /evidence="ECO:0000259|PROSITE:PS50937"
FT COILED 91..118
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 149 AA; 16745 MW; A23B2322238D20A7 CRC64;
MDTTRIIRQA QALTIGQVAR AAGVNVETIR FYQRRKLMDK PEKPLRGVRR YGRAAVDRVR
FIKRAQQLGF TLEEVRGLLA LQDGRSCGEA RRLAAAKLES VEERIADLQR MRRVLKTLIG
QCDTRRGQVA CPIISTLSGV VNAEARLGE
//
