ID A0A5C8JW07_9ACTN Unreviewed; 325 AA.
AC A0A5C8JW07;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 18-JUN-2025, entry version 16.
DE SubName: Full=2-dehydropantoate 2-reductase {ECO:0000313|EMBL:TXK42570.1};
GN ORFNames=FR742_26050 {ECO:0000313|EMBL:TXK42570.1};
OS Nonomuraea sp. C10.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Nonomuraea.
OX NCBI_TaxID=2600577 {ECO:0000313|EMBL:TXK42570.1, ECO:0000313|Proteomes:UP000321164};
RN [1] {ECO:0000313|EMBL:TXK42570.1, ECO:0000313|Proteomes:UP000321164}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C10 {ECO:0000313|EMBL:TXK42570.1,
RC ECO:0000313|Proteomes:UP000321164};
RA Aryal N., Rajbhandari P., Gross H.;
RT "Draft Genome Sequence of Nonomuraea sp. C10.";
RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TXK42570.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; VPFF01000001; TXK42570.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5C8JW07; -.
DR OrthoDB; 9796561at2; -.
DR Proteomes; UP000321164; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR FunFam; 1.10.1040.10:FF:000017; 2-dehydropantoate 2-reductase; 1.
DR FunFam; 3.40.50.720:FF:000307; 2-dehydropantoate 2-reductase; 1.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR051402; KPR-Related.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; NF005089; PRK06522.1-4; 1.
DR PANTHER; PTHR21708:SF45; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000321164}.
FT DOMAIN 3..104
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 196..314
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 325 AA; 34666 MW; 4938C4F2294A3553 CRC64;
MKVAVLGAGA IGAYVGAALH RAGVEVHLIA RGPHLEAIRK SGVMVLSPRG DFVAHPHATD
DPSEVGPVDH VFLGLKANHY AASGPMIKPL LHEATSVIAA QNGIPWWYFH GLKGPYEGYR
IESVDPGGTV TAALPLHRAV GCVVYAATEI ERPGVIRHYE GTRFSIGEPS GEPTARCAEF
SEAMVAGGLK CPVETDLRRD VWIKLMGNIA FNPISALARA TMAGICRHDG ARELVRSMMT
ETVDVARRVG CDPGISIERR LRGAEKAGEH KTSTLQDLEK GKPLELDVLL AAVVELADLT
GADVPTLRAI HAVSDLLNEN LVRAV
//
