ID A0A5E4DBM6_MARMO Unreviewed; 553 AA.
AC A0A5E4DBM6;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 28-JAN-2026, entry version 16.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|SMART:SM00181};
DE Flags: Fragment;
GN ORFNames=MONAX_5E020517 {ECO:0000313|EMBL:VTJ91140.1};
OS Marmota monax (Woodchuck).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Marmota.
OX NCBI_TaxID=9995 {ECO:0000313|EMBL:VTJ91140.1, ECO:0000313|Proteomes:UP000335636};
RN [1] {ECO:0000313|EMBL:VTJ91140.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:VTJ91140.1}.
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DR EMBL; CABDUW010006434; VTJ91140.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5E4DBM6; -.
DR Proteomes; UP000335636; Unassembled WGS sequence.
DR GO; GO:0007399; P:nervous system development; IEA:TreeGrafter.
DR FunFam; 2.120.10.30:FF:000001; Low-density lipoprotein receptor-related protein 6; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 3.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR050778; Cueball_EGF_LRP_Nidogen.
DR InterPro; IPR000742; EGF.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR PANTHER; PTHR46513:SF40; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00135; LY; 8.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF63825; YWTD domain; 2.
DR PROSITE; PS51120; LDLRB; 5.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000335636}.
FT DOMAIN 76..113
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 159..201
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 202..244
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 245..287
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 288..329
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 377..414
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 510..552
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 477..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:VTJ91140.1"
SQ SEQUENCE 553 AA; 62330 MW; AB91C4B5C6BD48D8 CRC64;
VINVDGTERR TLLEDKLPHI FGFTLLGDFI YWTDWQRRSI ERVHKVKASR DVIIDQLPDL
MGLKAVNVAK VIGTNPCAEG NGGCSHLCFF TPRATKCGCP IGLELLSDMR TCIVPEAFLV
FTSRAAIHRI SLETNNNDVA IPLAGVKEAS ALDFDVSNNH IYWTDVSLKT ISRAFMNGSS
VEHVIEFGLD YPEGMAVDWM GKNLYWADTG TNRIEVARLD GQFRQVLVWR DLDNPRSLAL
DPTKGYIYWT EWGGKPRIVR AFMDGTNGMT LVDKVGRAND LTIDYADQRL YWTDLDTNMI
ESSNMLGQDR VVIADDLPHP FGLTQYSDYI YWTDWNLHSI ERADKTSGRN RTLIQGHLDF
VMDILVFHSS RQDGLNDCMH NNGQCGQLCL AIPGGHRCGC ASHYTLDPSS RNCSPPSAFL
LFSQKCAISR MIPDDQRSPD LILPLHGLRN VKAIDYDPLD KFIYWVDGRQ NIKRAKDDGT
QPFVLTSPGQ SQNLSPDRQP HDLSIDIYSR MLFWTCEATN TINVHRLDGD AMGVVLRGER
DRPRAIAVNA ERG
//
