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Database: UniProt
Entry: A0A5F4W5S6_CALJA
LinkDB: A0A5F4W5S6_CALJA
Original site: A0A5F4W5S6_CALJA 
ID   A0A5F4W5S6_CALJA        Unreviewed;      2851 AA.
AC   A0A5F4W5S6;
DT   11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 2.
DT   18-JUN-2025, entry version 25.
DE   SubName: Full=Fibrillin 3 {ECO:0000313|Ensembl:ENSCJAP00000073166.2};
GN   Name=FBN3 {ECO:0000313|Ensembl:ENSCJAP00000073166.2};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000073166.2, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000073166.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000073166.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
CC   -!- SIMILARITY: Belongs to the fibrillin family.
CC       {ECO:0000256|ARBA:ARBA00008972}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   FunCoup; A0A5F4W5S6; 18.
DR   STRING; 9483.ENSCJAP00000073166; -.
DR   Ensembl; ENSCJAT00000094065.2; ENSCJAP00000073166.2; ENSCJAG00000006168.5.
DR   GeneTree; ENSGT00950000183158; -.
DR   InParanoid; A0A5F4W5S6; -.
DR   OMA; QGHCVFG; -.
DR   Proteomes; UP000008225; Chromosome 22.
DR   Bgee; ENSCJAG00000006168; Expressed in ovary and 1 other cell type or tissue.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0001527; C:microfibril; IEA:UniProtKB-ARBA.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00054; EGF_CA; 24.
DR   FunFam; 2.10.25.10:FF:000005; Fibrillin 2; 3.
DR   FunFam; 2.10.25.10:FF:000023; Fibrillin 2; 2.
DR   FunFam; 2.10.25.10:FF:000038; Fibrillin 2; 3.
DR   FunFam; 2.10.25.10:FF:000058; Fibrillin 2; 1.
DR   FunFam; 2.10.25.10:FF:000071; Fibrillin 2; 1.
DR   FunFam; 2.10.25.10:FF:000087; Fibrillin 2; 1.
DR   FunFam; 2.10.25.10:FF:000097; Fibrillin 2; 1.
DR   FunFam; 2.10.25.10:FF:000149; Fibrillin 2; 1.
DR   FunFam; 2.10.25.10:FF:000171; Fibrillin 2; 1.
DR   FunFam; 3.90.290.10:FF:000005; Fibrillin 2; 1.
DR   FunFam; 3.90.290.10:FF:000006; Fibrillin 2; 1.
DR   FunFam; 3.90.290.10:FF:000007; Fibrillin 2; 1.
DR   FunFam; 3.90.290.10:FF:000009; Fibrillin 2; 1.
DR   FunFam; 3.90.290.10:FF:000010; Fibrillin 2; 1.
DR   FunFam; 3.90.290.10:FF:000011; Fibrillin 2; 1.
DR   FunFam; 2.10.25.10:FF:000133; Fibrillin 3; 1.
DR   FunFam; 2.10.25.10:FF:000618; Fibrillin 3; 1.
DR   FunFam; 3.90.290.10:FF:000003; Fibrillin 3; 1.
DR   FunFam; 3.90.290.10:FF:000008; Fibrillin 3; 1.
DR   FunFam; 2.10.25.10:FF:000244; Fibrillin-1; 1.
DR   FunFam; 3.90.290.10:FF:000020; Fibrillin-1; 1.
DR   FunFam; 2.10.25.10:FF:000003; fibrillin-1 isoform X1; 15.
DR   FunFam; 2.10.25.10:FF:000002; Latent-transforming growth factor beta-binding protein 3; 1.
DR   FunFam; 2.10.25.10:FF:000014; Latent-transforming growth factor beta-binding protein 3; 1.
DR   FunFam; 2.10.25.10:FF:000010; Pro-epidermal growth factor; 2.
DR   FunFam; 2.10.25.10:FF:000096; Putative fibrillin 2; 1.
DR   FunFam; 2.10.25.10:FF:000008; Signal peptide, CUB domain, EGF-like 2; 1.
DR   Gene3D; 2.10.25.10; Laminin; 46.
DR   Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 9.
DR   InterPro; IPR026823; cEGF.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR024731; EGF_dom.
DR   InterPro; IPR049388; FBN_EGF_N.
DR   InterPro; IPR040872; Fibrillin_U_N.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR049883; NOTCH1_EGF-like.
DR   InterPro; IPR017878; TB_dom.
DR   InterPro; IPR036773; TB_dom_sf.
DR   InterPro; IPR052080; vWF_C/EGF_Fibrillin.
DR   PANTHER; PTHR47333:SF4; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF12662; cEGF; 5.
DR   Pfam; PF12947; EGF_3; 1.
DR   Pfam; PF07645; EGF_CA; 33.
DR   Pfam; PF21364; EGF_FBN_1st; 1.
DR   Pfam; PF18193; Fibrillin_U_N; 1.
DR   Pfam; PF14670; FXa_inhibition; 1.
DR   Pfam; PF12661; hEGF; 2.
DR   Pfam; PF00683; TB; 9.
DR   PIRSF; PIRSF036312; Fibrillin; 1.
DR   SMART; SM00181; EGF; 47.
DR   SMART; SM00179; EGF_CA; 44.
DR   SUPFAM; SSF57196; EGF/Laminin; 7.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 13.
DR   SUPFAM; SSF57581; TB module/8-cys domain; 9.
DR   PROSITE; PS00010; ASX_HYDROXYL; 40.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 28.
DR   PROSITE; PS50026; EGF_3; 38.
DR   PROSITE; PS01187; EGF_CA; 15.
DR   PROSITE; PS51364; TB; 9.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           32..2851
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5035277675"
FT   DOMAIN          147..179
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          185..228
FT                   /note="TB"
FT                   /evidence="ECO:0000259|PROSITE:PS51364"
FT   DOMAIN          247..284
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          289..330
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          335..388
FT                   /note="TB"
FT                   /evidence="ECO:0000259|PROSITE:PS51364"
FT   DOMAIN          491..526
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          531..572
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          573..613
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          614..654
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          660..712
FT                   /note="TB"
FT                   /evidence="ECO:0000259|PROSITE:PS51364"
FT   DOMAIN          724..765
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          766..807
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          808..847
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          852..891
FT                   /note="TB"
FT                   /evidence="ECO:0000259|PROSITE:PS51364"
FT   DOMAIN          911..952
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          957..1008
FT                   /note="TB"
FT                   /evidence="ECO:0000259|PROSITE:PS51364"
FT   DOMAIN          1028..1069
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1070..1112
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1113..1154
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1155..1196
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1280..1317
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1322..1360
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1363..1403
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1404..1445
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1446..1486
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1487..1527
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1532..1588
FT                   /note="TB"
FT                   /evidence="ECO:0000259|PROSITE:PS51364"
FT   DOMAIN          1605..1646
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1693..1745
FT                   /note="TB"
FT                   /evidence="ECO:0000259|PROSITE:PS51364"
FT   DOMAIN          1763..1804
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1805..1846
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1889..1924
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1928..1970
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1971..2010
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          2011..2052
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          2057..2110
FT                   /note="TB"
FT                   /evidence="ECO:0000259|PROSITE:PS51364"
FT   DOMAIN          2126..2163
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          2168..2207
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          2208..2248
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          2249..2293
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          2294..2335
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          2340..2393
FT                   /note="TB"
FT                   /evidence="ECO:0000259|PROSITE:PS51364"
FT   DOMAIN          2405..2446
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          2488..2524
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          2527..2569
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          2570..2609
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          2610..2647
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DISULFID        151..161
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        169..178
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        495..505
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        812..822
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1893..1903
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        2574..2584
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   2851 AA;  304956 MW;  745C2C3E424A1DA4 CRC64;
     MTLEGLCLAR GPLARLLLAC SALSCMAGGQ GRWDGASEAS GPGRVRRRGS PGILQGPNVC
     GSRFHAYCCP GWRTFPGRSQ CVVPICRHTC HEGFCSQPNL CTCADGTLAP SCGVSLGLGC
     SVSCMNGGTC RGASCLCQRG YTGTVCGQPI CDRGCHNRGR CIGPNHCACV YGFMGPQCER
     DYRMGPCFGR VGPEGCQHQL TSLVCTKALC CATVGRAWGL PCELCPAQPH PCRRGFIPNI
     HTGACQDVDE CQAVPGLCQG GSCMNTVGSF HCRCPAGHRL SDSSAACEDV NECLSVPGLY
     SGGDCTNTVG NYVCTCPWGF ASSLDGTHCL DQRVGTCFSV LFGGRCAGDL TGYYTHRQCC
     CDKGRCWVAG PTPELCPPQG SNEFQQLCTP ALPLLPGHPG LFPGLLGFRS NGMGPALGPA
     RLNPHGSNGR GVPSLGPGNS NIGTATLNQT TDICRHFTNL CLNGRCLPTP SSYRCECNVG
     YIQDVRGECI DVDECTSSPC HHGDCVNIPG TYHCRCHPGF QATLTRQACV DVDECIVSGG
     LCHLGRCVNT EGSFQCVCNA GFELSPDGKN CVDHNECATS TMCTNGVCLN EDGSFSCLCK
     PGFLLAPDSH YCMDIDECQL PGICVNGHCT NTEGSFHCQC LGGLAMGEDG RMCVDTHVRS
     TCYGAIEKGS CARPFPDTVT KSECCCANPD HSFGEPCKLC PAKNSAEFQA LCSSGLGITT
     DGRDINECAL DPEVCANGMC ENLQGSYRCI CNLGYEAGAS GKDCTDLDEC ALNSLLCDNG
     WCQNSPGSYS CSCPQGFSFW QDTKTCEDID ECLSSPCVNG ICQNVAGSYT CRCAPGSRLG
     PSGTICLDST KGTCWLKIQE SRCEVNLQGA TLRSECCATL GAAWGSPCER CEIDPACARG
     FARMTGATCD DVNECESFPG VCPNGRCINT AGSFRCECPE GLMLDASGRL CMDMRLEQCF
     LQWDEDECGA ALPGKYRMDV CCCSIGAAWG AECEACPDPE SLEFTSLCPR GQGFASRDFL
     SGRPFYKDVN ECKAFPGLCT HGTCRNTVGS FHCTCSGGFA LDAQEWNCTD IDECRISPDL
     CGQGTCVNTP GSFECSCFPG YKSGFMMMKE CLDVDECARD PLLCRGGTCT NMDGSYKCQC
     PPGHELTAEG TTCEDIDECS LKDDLCPHGQ CVNVIGAFQC SCHAGFQGTP DRQGCVDINE
     CQVQNGGCDM HCINTEGSYR CSCGQGYSLM PNGRACADVD ECDENPGVCD QGHCSNVLGG
     HRCLCYDGFM ATPDMRTCVD VNECDLNPHI CLHGDCKNTK GSFVCHCELG YTVRKGATGC
     SDVDECEVGG HNCDSHASCL NIPGSFSCRC LPGWVGDGFE CHDLDECVSW EHRCSPRGNC
     QNVPGSYRCT CRQGFAGDGF SCEDRDECAE NVDLCDNGQC LNVPGGYRCE CEMGFHPTED
     HRACQDVDEC VQGNLCVFGS CENLPGMFRC NCDGGYELDR GGSNCTDINE CADPVNCING
     VCINSPGSYL CSCPQDFELN PSGVGCVDTR VGNCFLETHD RGDGGISCSA EIGVGVSRAS
     CCCSLGQAWG NPCELCPVTN TTEYRTLCPG GEGFRPNPIT VILEDIDECQ ELPGLCQGGD
     CANTFGSFQC ECPPGYHLSE HTRICEDIDE CYTHSGICGP GTCYNTLGNY TCVCPAEYLQ
     VNGGNNCMDM RKSVCFRHYN GTCQNELAFN VTQKMCCCSY NIGQAWNRPC EACPTPTSPD
     YQILCGNQAP GFIIDIHTGK PLDIDECGEI PAICANGICI NQIGSFRCKC PTGFKYNSIL
     LACEDVNECG SRESPCQQNA DCINIPGSYR CKCTRGYKPS PGGACVGRNE CREIPDVCSH
     GNCMDTDGSY MCLCHRGFQA STDHTLCMDI DECDQQPCGN GTCKNIIGSY NCLCFPGFVV
     THNGDCVDFD ECTTLVEQVC RFGQCLNTAG SFHCLCKEGF ELTADGKNCV DTNECLSLAG
     TCLPGTCQNL EGSFRCICPP GFQVLSDHCI DIDECSEEPN LCLFGTCTNS PGSFQCLCPP
     GFVLSDNGHR CFDTRQSFCF TRFEAGKCSV PKAFNTTKTR CCCRKRPGEG WGDPCELCPQ
     EGSAAFQELC PFGHGAVPGP DNSREDVNEC VENPGVCTNG ICVNTDGSFR CECPFGYSLD
     FTGISCVDTD ECSIGHPCGQ GTCTNIIGGF KCACADGFEP GPIMTCEDID ECSLNPLLCA
     FRCHNTEGSY LCTCPAGYTL REDGAMCRDV DECADGQQDC HARGMECKNL IGTFTCVCPP
     GMRPLPSSGE GCTDDDECRA QPDLCVSGRC VNTVGSFRCD CDEGFQPSPA LTECHDIRQG
     PCFAEVLQAT CQALSSDSEA VTRAECCCGG GRAWGPHCEL CPLPSTSTYR KLCPHGSGYT
     TEGRDVDECR MLAHLCAHGE CINSLGSFHC HCQAGYTPDA TTTTCLDEDE CSQVPKPCTF
     LCKNTKGSFL CSCPRGYLLE DDGRTCKDLD ECTSRQHNCQ FLCVNTVGAF TCRCPPGFTQ
     RHQACFDNDE CSAQPGPCGA RGHCHNTPGS FRCECHQGFT LDSSGHGCED VNECDGPHHC
     QHGCQNHLGG YRCSCPQGFT QHSQWAQCVD ENECALLPPT CGSASCRNTL GGFRCVCPSG
     FDFDQALGGC QDVDECAGRG GPCSYSCANT PGGFLCGCPQ GYFRAGQGHC VSGLGFSPGP
     QDAPDKEELL SSEACYECKI NGLSPRDRPR CSVPRDHQVS LATLDSEALL TLGLNLSHLG
     RAEHILELRP ALEGLEGRVR YVIAQGNEQG FFRMHHIRGC SSLKLGRRRP GPGIYQLELV
     SHVAGPWGVQ PEGQPGPWGQ ALRLKVQLQL L
//
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