ID A0A5F4W5S6_CALJA Unreviewed; 2851 AA.
AC A0A5F4W5S6;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 18-JUN-2025, entry version 25.
DE SubName: Full=Fibrillin 3 {ECO:0000313|Ensembl:ENSCJAP00000073166.2};
GN Name=FBN3 {ECO:0000313|Ensembl:ENSCJAP00000073166.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000073166.2, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000073166.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000073166.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the fibrillin family.
CC {ECO:0000256|ARBA:ARBA00008972}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR FunCoup; A0A5F4W5S6; 18.
DR STRING; 9483.ENSCJAP00000073166; -.
DR Ensembl; ENSCJAT00000094065.2; ENSCJAP00000073166.2; ENSCJAG00000006168.5.
DR GeneTree; ENSGT00950000183158; -.
DR InParanoid; A0A5F4W5S6; -.
DR OMA; QGHCVFG; -.
DR Proteomes; UP000008225; Chromosome 22.
DR Bgee; ENSCJAG00000006168; Expressed in ovary and 1 other cell type or tissue.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0001527; C:microfibril; IEA:UniProtKB-ARBA.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 24.
DR FunFam; 2.10.25.10:FF:000005; Fibrillin 2; 3.
DR FunFam; 2.10.25.10:FF:000023; Fibrillin 2; 2.
DR FunFam; 2.10.25.10:FF:000038; Fibrillin 2; 3.
DR FunFam; 2.10.25.10:FF:000058; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000071; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000087; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000097; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000149; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000171; Fibrillin 2; 1.
DR FunFam; 3.90.290.10:FF:000005; Fibrillin 2; 1.
DR FunFam; 3.90.290.10:FF:000006; Fibrillin 2; 1.
DR FunFam; 3.90.290.10:FF:000007; Fibrillin 2; 1.
DR FunFam; 3.90.290.10:FF:000009; Fibrillin 2; 1.
DR FunFam; 3.90.290.10:FF:000010; Fibrillin 2; 1.
DR FunFam; 3.90.290.10:FF:000011; Fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000133; Fibrillin 3; 1.
DR FunFam; 2.10.25.10:FF:000618; Fibrillin 3; 1.
DR FunFam; 3.90.290.10:FF:000003; Fibrillin 3; 1.
DR FunFam; 3.90.290.10:FF:000008; Fibrillin 3; 1.
DR FunFam; 2.10.25.10:FF:000244; Fibrillin-1; 1.
DR FunFam; 3.90.290.10:FF:000020; Fibrillin-1; 1.
DR FunFam; 2.10.25.10:FF:000003; fibrillin-1 isoform X1; 15.
DR FunFam; 2.10.25.10:FF:000002; Latent-transforming growth factor beta-binding protein 3; 1.
DR FunFam; 2.10.25.10:FF:000014; Latent-transforming growth factor beta-binding protein 3; 1.
DR FunFam; 2.10.25.10:FF:000010; Pro-epidermal growth factor; 2.
DR FunFam; 2.10.25.10:FF:000096; Putative fibrillin 2; 1.
DR FunFam; 2.10.25.10:FF:000008; Signal peptide, CUB domain, EGF-like 2; 1.
DR Gene3D; 2.10.25.10; Laminin; 46.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 9.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR049388; FBN_EGF_N.
DR InterPro; IPR040872; Fibrillin_U_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR049883; NOTCH1_EGF-like.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR InterPro; IPR052080; vWF_C/EGF_Fibrillin.
DR PANTHER; PTHR47333:SF4; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12662; cEGF; 5.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 33.
DR Pfam; PF21364; EGF_FBN_1st; 1.
DR Pfam; PF18193; Fibrillin_U_N; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF00683; TB; 9.
DR PIRSF; PIRSF036312; Fibrillin; 1.
DR SMART; SM00181; EGF; 47.
DR SMART; SM00179; EGF_CA; 44.
DR SUPFAM; SSF57196; EGF/Laminin; 7.
DR SUPFAM; SSF57184; Growth factor receptor domain; 13.
DR SUPFAM; SSF57581; TB module/8-cys domain; 9.
DR PROSITE; PS00010; ASX_HYDROXYL; 40.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 28.
DR PROSITE; PS50026; EGF_3; 38.
DR PROSITE; PS01187; EGF_CA; 15.
DR PROSITE; PS51364; TB; 9.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..2851
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035277675"
FT DOMAIN 147..179
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 185..228
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 247..284
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 289..330
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 335..388
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 491..526
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 531..572
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 573..613
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 614..654
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 660..712
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 724..765
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 766..807
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 808..847
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 852..891
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 911..952
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 957..1008
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1028..1069
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1070..1112
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1113..1154
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1155..1196
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1280..1317
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1322..1360
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1363..1403
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1404..1445
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1446..1486
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1487..1527
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1532..1588
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1605..1646
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1693..1745
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1763..1804
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1805..1846
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1889..1924
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1928..1970
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1971..2010
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2011..2052
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2057..2110
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2126..2163
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2168..2207
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2208..2248
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2249..2293
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2294..2335
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2340..2393
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2405..2446
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2488..2524
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2527..2569
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2570..2609
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2610..2647
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 151..161
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 169..178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 495..505
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 812..822
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1893..1903
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2574..2584
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2851 AA; 304956 MW; 745C2C3E424A1DA4 CRC64;
MTLEGLCLAR GPLARLLLAC SALSCMAGGQ GRWDGASEAS GPGRVRRRGS PGILQGPNVC
GSRFHAYCCP GWRTFPGRSQ CVVPICRHTC HEGFCSQPNL CTCADGTLAP SCGVSLGLGC
SVSCMNGGTC RGASCLCQRG YTGTVCGQPI CDRGCHNRGR CIGPNHCACV YGFMGPQCER
DYRMGPCFGR VGPEGCQHQL TSLVCTKALC CATVGRAWGL PCELCPAQPH PCRRGFIPNI
HTGACQDVDE CQAVPGLCQG GSCMNTVGSF HCRCPAGHRL SDSSAACEDV NECLSVPGLY
SGGDCTNTVG NYVCTCPWGF ASSLDGTHCL DQRVGTCFSV LFGGRCAGDL TGYYTHRQCC
CDKGRCWVAG PTPELCPPQG SNEFQQLCTP ALPLLPGHPG LFPGLLGFRS NGMGPALGPA
RLNPHGSNGR GVPSLGPGNS NIGTATLNQT TDICRHFTNL CLNGRCLPTP SSYRCECNVG
YIQDVRGECI DVDECTSSPC HHGDCVNIPG TYHCRCHPGF QATLTRQACV DVDECIVSGG
LCHLGRCVNT EGSFQCVCNA GFELSPDGKN CVDHNECATS TMCTNGVCLN EDGSFSCLCK
PGFLLAPDSH YCMDIDECQL PGICVNGHCT NTEGSFHCQC LGGLAMGEDG RMCVDTHVRS
TCYGAIEKGS CARPFPDTVT KSECCCANPD HSFGEPCKLC PAKNSAEFQA LCSSGLGITT
DGRDINECAL DPEVCANGMC ENLQGSYRCI CNLGYEAGAS GKDCTDLDEC ALNSLLCDNG
WCQNSPGSYS CSCPQGFSFW QDTKTCEDID ECLSSPCVNG ICQNVAGSYT CRCAPGSRLG
PSGTICLDST KGTCWLKIQE SRCEVNLQGA TLRSECCATL GAAWGSPCER CEIDPACARG
FARMTGATCD DVNECESFPG VCPNGRCINT AGSFRCECPE GLMLDASGRL CMDMRLEQCF
LQWDEDECGA ALPGKYRMDV CCCSIGAAWG AECEACPDPE SLEFTSLCPR GQGFASRDFL
SGRPFYKDVN ECKAFPGLCT HGTCRNTVGS FHCTCSGGFA LDAQEWNCTD IDECRISPDL
CGQGTCVNTP GSFECSCFPG YKSGFMMMKE CLDVDECARD PLLCRGGTCT NMDGSYKCQC
PPGHELTAEG TTCEDIDECS LKDDLCPHGQ CVNVIGAFQC SCHAGFQGTP DRQGCVDINE
CQVQNGGCDM HCINTEGSYR CSCGQGYSLM PNGRACADVD ECDENPGVCD QGHCSNVLGG
HRCLCYDGFM ATPDMRTCVD VNECDLNPHI CLHGDCKNTK GSFVCHCELG YTVRKGATGC
SDVDECEVGG HNCDSHASCL NIPGSFSCRC LPGWVGDGFE CHDLDECVSW EHRCSPRGNC
QNVPGSYRCT CRQGFAGDGF SCEDRDECAE NVDLCDNGQC LNVPGGYRCE CEMGFHPTED
HRACQDVDEC VQGNLCVFGS CENLPGMFRC NCDGGYELDR GGSNCTDINE CADPVNCING
VCINSPGSYL CSCPQDFELN PSGVGCVDTR VGNCFLETHD RGDGGISCSA EIGVGVSRAS
CCCSLGQAWG NPCELCPVTN TTEYRTLCPG GEGFRPNPIT VILEDIDECQ ELPGLCQGGD
CANTFGSFQC ECPPGYHLSE HTRICEDIDE CYTHSGICGP GTCYNTLGNY TCVCPAEYLQ
VNGGNNCMDM RKSVCFRHYN GTCQNELAFN VTQKMCCCSY NIGQAWNRPC EACPTPTSPD
YQILCGNQAP GFIIDIHTGK PLDIDECGEI PAICANGICI NQIGSFRCKC PTGFKYNSIL
LACEDVNECG SRESPCQQNA DCINIPGSYR CKCTRGYKPS PGGACVGRNE CREIPDVCSH
GNCMDTDGSY MCLCHRGFQA STDHTLCMDI DECDQQPCGN GTCKNIIGSY NCLCFPGFVV
THNGDCVDFD ECTTLVEQVC RFGQCLNTAG SFHCLCKEGF ELTADGKNCV DTNECLSLAG
TCLPGTCQNL EGSFRCICPP GFQVLSDHCI DIDECSEEPN LCLFGTCTNS PGSFQCLCPP
GFVLSDNGHR CFDTRQSFCF TRFEAGKCSV PKAFNTTKTR CCCRKRPGEG WGDPCELCPQ
EGSAAFQELC PFGHGAVPGP DNSREDVNEC VENPGVCTNG ICVNTDGSFR CECPFGYSLD
FTGISCVDTD ECSIGHPCGQ GTCTNIIGGF KCACADGFEP GPIMTCEDID ECSLNPLLCA
FRCHNTEGSY LCTCPAGYTL REDGAMCRDV DECADGQQDC HARGMECKNL IGTFTCVCPP
GMRPLPSSGE GCTDDDECRA QPDLCVSGRC VNTVGSFRCD CDEGFQPSPA LTECHDIRQG
PCFAEVLQAT CQALSSDSEA VTRAECCCGG GRAWGPHCEL CPLPSTSTYR KLCPHGSGYT
TEGRDVDECR MLAHLCAHGE CINSLGSFHC HCQAGYTPDA TTTTCLDEDE CSQVPKPCTF
LCKNTKGSFL CSCPRGYLLE DDGRTCKDLD ECTSRQHNCQ FLCVNTVGAF TCRCPPGFTQ
RHQACFDNDE CSAQPGPCGA RGHCHNTPGS FRCECHQGFT LDSSGHGCED VNECDGPHHC
QHGCQNHLGG YRCSCPQGFT QHSQWAQCVD ENECALLPPT CGSASCRNTL GGFRCVCPSG
FDFDQALGGC QDVDECAGRG GPCSYSCANT PGGFLCGCPQ GYFRAGQGHC VSGLGFSPGP
QDAPDKEELL SSEACYECKI NGLSPRDRPR CSVPRDHQVS LATLDSEALL TLGLNLSHLG
RAEHILELRP ALEGLEGRVR YVIAQGNEQG FFRMHHIRGC SSLKLGRRRP GPGIYQLELV
SHVAGPWGVQ PEGQPGPWGQ ALRLKVQLQL L
//