ID A0A5F5PRE6_HORSE Unreviewed; 913 AA.
AC A0A5F5PRE6;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 18-JUN-2025, entry version 27.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBPL6 {ECO:0000313|Ensembl:ENSECAP00000050826.2,
GN ECO:0000313|VGNC:VGNC:21067};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000050826.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000050826.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000050826.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000050826.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000050826.2};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Endoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004586}.
CC -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000256|ARBA:ARBA00008842,
CC ECO:0000256|RuleBase:RU003844}.
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DR RefSeq; XP_070097409.1; XM_070241308.1.
DR AlphaFoldDB; A0A5F5PRE6; -.
DR Ensembl; ENSECAT00000071720.2; ENSECAP00000050826.2; ENSECAG00000020078.4.
DR GeneID; 100067212; -.
DR VGNC; VGNC:21067; OSBPL6.
DR GeneTree; ENSGT00940000156791; -.
DR Proteomes; UP000002281; Chromosome 18.
DR Bgee; ENSECAG00000020078; Expressed in epithelium of bronchus and 22 other cell types or tissues.
DR ExpressionAtlas; A0A5F5PRE6; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0005319; F:lipid transporter activity; IEA:UniProtKB-ARBA.
DR CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR FunFam; 2.30.29.30:FF:000011; Oxysterol-binding protein; 1.
DR FunFam; 2.40.160.120:FF:000001; Oxysterol-binding protein; 1.
DR FunFam; 3.30.70.3490:FF:000002; Oxysterol-binding protein; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF76; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 6; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 65..160
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT COILED 399..426
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 913 AA; 104298 MW; B21EAE4158C0951B CRC64;
MQHFSLSRGI KWRSLHVLER TASSSTEPSM SRQLLEPEPV PLSKEADSWE IIEGLKIGQT
NVQRPDKHEG FMLKKRKWPL KGWHKRFFVL DNGMLKYSKA PLDIQKGKVH GSIDVGLSVM
SIKKKARRID LDTEEHIYHL KVKSQDWFDA WVSKLRHHRL YRQNEIVRSP RDASFHIFPS
TSTAESSPAA NVSTVDGKVQ PNSFPWQSPL PCSNSLPATC TTGQSKVAAW LQDSEEMDRC
AEDLAHCQSN LVELSKLLQN LEILQRTQSA PNFTDMQANC VDISKKDKRV TRRWRTKSVS
KDTKIQLQVP FSATMSPVRL HSSNPNLCAD IEFQTPPSHL TDPLESSTDY TKLQEEFCLI
AQKVHSLLKS AFNSIAIEKE KLKQMVSEQD HNKGHSTQMA RLRQSLSQAL NQNAELRSRL
NRIHSESIIC DQVVSVNIIP SPDEAGEQIH VNLPLSQQVA NESRLSMSES VSEFFDAQEV
LLSASSSENE ASDDESYISD VSDNISEDNT SVADNISRQI LNGELTGGAF RNGRRTCLPA
PCPDTSNINL WNILRNNIGK DLSKVSMPVE LNEPLNTLQH LCEEIEYSEL LDKASETDDP
YERMVLIAAF AVSGYCSTYF RAGSKPFNPV LGETYECIRE DKGFRFFSEQ VSHHPPISAC
HCESKNFVFW QDIRWKNKFW GKSMEILPVG TLNVMLPKYG DCYVWNKVTT CIHNILSGRR
WIEHYGEVTI RNTKSSVCIC KLTFVKVNYW NSNVNEVQGV VMDQEGKVVH RLFGKWHEGL
YCGVAPSAKC IWRPGSMPTN YELYYGFTRF AIELNELDPV LKDLLPPTDA RFRPDQRFLE
EGNVEAAAAE KQRVEELQRS RRRYMEENNL EHRPKFFKKV SDANQREAWV SNDTYWELRK
DPGFSKVDSP VLW
//