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Database: UniProt
Entry: A0A5F5PRE6_HORSE
LinkDB: A0A5F5PRE6_HORSE
Original site: A0A5F5PRE6_HORSE 
ID   A0A5F5PRE6_HORSE        Unreviewed;       913 AA.
AC   A0A5F5PRE6;
DT   11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 2.
DT   18-JUN-2025, entry version 27.
DE   RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN   Name=OSBPL6 {ECO:0000313|Ensembl:ENSECAP00000050826.2,
GN   ECO:0000313|VGNC:VGNC:21067};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000050826.2, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000050826.2, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000050826.2,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000050826.2}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000050826.2};
RG   Ensembl;
RL   Submitted (MAR-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Endoplasmic
CC       reticulum membrane {ECO:0000256|ARBA:ARBA00004586}.
CC   -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000256|ARBA:ARBA00008842,
CC       ECO:0000256|RuleBase:RU003844}.
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DR   RefSeq; XP_070097409.1; XM_070241308.1.
DR   AlphaFoldDB; A0A5F5PRE6; -.
DR   Ensembl; ENSECAT00000071720.2; ENSECAP00000050826.2; ENSECAG00000020078.4.
DR   GeneID; 100067212; -.
DR   VGNC; VGNC:21067; OSBPL6.
DR   GeneTree; ENSGT00940000156791; -.
DR   Proteomes; UP000002281; Chromosome 18.
DR   Bgee; ENSECAG00000020078; Expressed in epithelium of bronchus and 22 other cell types or tissues.
DR   ExpressionAtlas; A0A5F5PRE6; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0005319; F:lipid transporter activity; IEA:UniProtKB-ARBA.
DR   CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR   FunFam; 2.30.29.30:FF:000011; Oxysterol-binding protein; 1.
DR   FunFam; 2.40.160.120:FF:000001; Oxysterol-binding protein; 1.
DR   FunFam; 3.30.70.3490:FF:000002; Oxysterol-binding protein; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 3.30.70.3490; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041680; PH_8.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10972:SF76; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 6; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   Pfam; PF15409; PH_8; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01013; OSBP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW   ECO:0000256|RuleBase:RU003845};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT   DOMAIN          65..160
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   COILED          399..426
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   913 AA;  104298 MW;  B21EAE4158C0951B CRC64;
     MQHFSLSRGI KWRSLHVLER TASSSTEPSM SRQLLEPEPV PLSKEADSWE IIEGLKIGQT
     NVQRPDKHEG FMLKKRKWPL KGWHKRFFVL DNGMLKYSKA PLDIQKGKVH GSIDVGLSVM
     SIKKKARRID LDTEEHIYHL KVKSQDWFDA WVSKLRHHRL YRQNEIVRSP RDASFHIFPS
     TSTAESSPAA NVSTVDGKVQ PNSFPWQSPL PCSNSLPATC TTGQSKVAAW LQDSEEMDRC
     AEDLAHCQSN LVELSKLLQN LEILQRTQSA PNFTDMQANC VDISKKDKRV TRRWRTKSVS
     KDTKIQLQVP FSATMSPVRL HSSNPNLCAD IEFQTPPSHL TDPLESSTDY TKLQEEFCLI
     AQKVHSLLKS AFNSIAIEKE KLKQMVSEQD HNKGHSTQMA RLRQSLSQAL NQNAELRSRL
     NRIHSESIIC DQVVSVNIIP SPDEAGEQIH VNLPLSQQVA NESRLSMSES VSEFFDAQEV
     LLSASSSENE ASDDESYISD VSDNISEDNT SVADNISRQI LNGELTGGAF RNGRRTCLPA
     PCPDTSNINL WNILRNNIGK DLSKVSMPVE LNEPLNTLQH LCEEIEYSEL LDKASETDDP
     YERMVLIAAF AVSGYCSTYF RAGSKPFNPV LGETYECIRE DKGFRFFSEQ VSHHPPISAC
     HCESKNFVFW QDIRWKNKFW GKSMEILPVG TLNVMLPKYG DCYVWNKVTT CIHNILSGRR
     WIEHYGEVTI RNTKSSVCIC KLTFVKVNYW NSNVNEVQGV VMDQEGKVVH RLFGKWHEGL
     YCGVAPSAKC IWRPGSMPTN YELYYGFTRF AIELNELDPV LKDLLPPTDA RFRPDQRFLE
     EGNVEAAAAE KQRVEELQRS RRRYMEENNL EHRPKFFKKV SDANQREAWV SNDTYWELRK
     DPGFSKVDSP VLW
//
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