ID A0A5F5XF39_FELCA Unreviewed; 869 AA.
AC A0A5F5XF39;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 18-JUN-2025, entry version 28.
DE RecName: Full=Interleukin-6 receptor subunit beta {ECO:0000256|ARBA:ARBA00068277};
DE AltName: Full=Interleukin-6 signal transducer {ECO:0000256|ARBA:ARBA00078919};
DE AltName: Full=Membrane glycoprotein 130 {ECO:0000256|ARBA:ARBA00077050};
DE AltName: Full=Oncostatin-M receptor subunit alpha {ECO:0000256|ARBA:ARBA00083382};
GN Name=IL6ST {ECO:0000313|Ensembl:ENSFCAP00000052500.1,
GN ECO:0000313|VGNC:VGNC:67783};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000052500.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000052500.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000052500.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000052500.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000052500.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000052500.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000052500.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR EMBL; AANG04002524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A5F5XF39; -.
DR Ensembl; ENSFCAT00000084327.1; ENSFCAP00000052500.1; ENSFCAG00000010859.6.
DR VGNC; VGNC:67783; IL6ST.
DR GeneTree; ENSGT00940000159608; -.
DR Proteomes; UP000011712; Chromosome A1.
DR Bgee; ENSFCAG00000010859; Expressed in liver and 10 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR FunFam; 2.60.40.10:FF:000281; Cytokine receptor like factor 1; 1.
DR FunFam; 2.60.40.10:FF:000414; Interleukin-6 receptor subunit beta; 1.
DR FunFam; 2.60.40.10:FF:000524; Interleukin-6 receptor subunit beta; 1.
DR FunFam; 2.60.40.10:FF:000563; interleukin-6 receptor subunit beta; 1.
DR FunFam; 2.60.40.10:FF:000855; Interleukin-6 receptor subunit beta; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010457; IgC2-like_lig-bd.
DR InterPro; IPR050379; Type-I_Cytokine_Rcpt.
DR InterPro; IPR015321; TypeI_recpt_CBD.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF16; CYTOKINE RECEPTOR-LIKE FACTOR 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF09240; IL6Ra-bind; 1.
DR Pfam; PF06328; Lep_receptor_Ig; 1.
DR SMART; SM00060; FN3; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..869
FT /note="Interleukin-6 receptor subunit beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023920691"
FT TRANSMEM 572..592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 224..324
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 423..519
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 673..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..696
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 869 AA; 98357 MW; 14A6883DDAFD8CD9 CRC64;
MLTLKTWIVQ ALFIFFTTES VGELLEPCGH IKPESPVVQL GSNFTAVCVL KEKCMDYFHV
NANYIFWKTN HVTVPKEQYT IINRTASSVT FTDISLLNIQ LTCNIRTFGQ IDQNVYGIRI
ISGLPPEKPK NLSCIVNEGK KMMCQWDPGR ETYLETNFTL KSEWATEKFA DCKTKRDTPT
SCTVDYSPVY FVNIEVWVEA ENALGKVTSD HINFDPVDKV KPNPPHNLSV SNSEELSSIL
KLTWINSSIQ SFIRLKYNIQ YRTRDASTWS QIPPEDTASS RTSFTVQDLK PFTEYVFRIR
CMKEDGKGFW SDWSEEASGI TYEDRPSKAP SFWYKIEPSH THGYRSVQLI WKTLPPFEAN
GKILDYEVTL IRWKSRLQNY TVNDTKWTVN LTNDRYIATL TARNLVGKSD AAVLTIPAYN
FQATRPVTDL KAFPKDNMLW VEWTAPNESV NKYILEWCVL SDKSPCIPDW QQEDGTVHRT
FLRGNLAESK CYLITVTPVY TDGPGSPESI KAYLKQAPVN VDSSHTEYTL SSLTSDTLYM
VRMAAYTDEG GKDGPEFTFT TPKFAQGEIE AIVVPVCLAF LLTTLLGVLF CFNKRDLIKK
HIWPNVPDPS KSHIAQWSPH TPPRHNFNSK DQIYSDGNFT DVSVVEIEAA NDKKPFPEDL
KSLDLFKKEK ISTEGHSSGI GGSSCMSSSR PSISSSDENE SAQNTSGTVQ YSTVVHSGYR
HQVPSVQVFS RSESTQPLLD SEERPEDLQL VDNTDSSVGN LPRQQYFKQN CSQRETSPDI
SHFERSKQVS SVNEEDFVRL KQQISDISQS CGSGQMKMFQ EISVADAFGL HTEGQVERFE
TVGMEAAVDE GMSKSYLPQT VRRGGYMPQ
//
