ID A0A5F5XKZ4_FELCA Unreviewed; 541 AA.
AC A0A5F5XKZ4;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 18-JUN-2025, entry version 28.
DE RecName: Full=HTH CENPB-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=CENPBD1 {ECO:0000313|Ensembl:ENSFCAP00000054545.1};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000054545.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000054545.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000054545.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000054545.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000054545.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000054545.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000054545.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00320}.
CC -!- SIMILARITY: Belongs to the tigger transposable element derived protein
CC family. {ECO:0000256|ARBA:ARBA00010881}.
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DR EMBL; AANG04002512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A5F5XKZ4; -.
DR Ensembl; ENSFCAT00000063772.2; ENSFCAP00000054545.1; ENSFCAG00000042675.2.
DR GeneID; 101083729; -.
DR KEGG; fca:101083729; -.
DR CTD; 100683197; -.
DR GeneTree; ENSGT00940000163154; -.
DR InParanoid; A0A5F5XKZ4; -.
DR OMA; PCHPVNL; -.
DR OrthoDB; 125347at2759; -.
DR Proteomes; UP000011712; Chromosome E2.
DR Bgee; ENSFCAG00000042675; Expressed in embryonic head and 10 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR050863; CenT-Element_Derived.
DR InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR InterPro; IPR009057; Homeodomain-like_sf.
DR InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR InterPro; IPR007889; HTH_Psq.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR19303:SF59; HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR19303; TRANSPOSON; 1.
DR Pfam; PF04218; CENP-B_N; 1.
DR Pfam; PF03184; DDE_1; 1.
DR Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR SMART; SM00674; CENPB; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51253; HTH_CENPB; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00320}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00320};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 13..64
FT /note="HTH psq-type"
FT /evidence="ECO:0000259|PROSITE:PS50960"
FT DOMAIN 78..157
FT /note="HTH CENPB-type"
FT /evidence="ECO:0000259|PROSITE:PS51253"
FT DNA_BIND 40..60
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00320"
SQ SEQUENCE 541 AA; 61566 MW; 6F368C6C6DE00195 CRC64;
MPGKRSLNAS AIPSAKRERK AITLDIKLEV LRRFEVGEKL SQIAKALGLA VSTVATIRDN
KEKIKANSQI ATPLRASRLT RHRSAVMETM ERLLHVWLED QSQRNVPLSV TIIQEKAKSL
FDDLQRERGA SSQTEKFTAS KGWFVRFKER HCLPHFKINS TAPGNKDIYP KALRSIIEEG
EYTPQQVFNV DETGLYWKRM PEGTFISVEE KAEPGFKSSR DRLMLLLGGN AAGDFKLKPL
LVYHLENPKA LKGYSKPNLP VIWRSNKKAW ATRSIFQEWF TYFFCPAVER YCAQNNLTHK
ALLILDNAPC HPVNLSDLSD NVRVEYLHDS TADSIQPMGQ GIASAFKAHY VRRTFEHILE
ATDGEDTAMI REFWRNYSIM DAVDNIALAW EALRPATMNS VWKKIWPECV RFQSVSQTDN
IAQLQQNIVT LAKNVAFEEV VEADVDQLLR SHEEDLSNTE LMQLEQEPAE EESEDAPPAL
RQLTTGRLSA AFSHFEAGLQ VLTSDGPNDD WKLKVSGAIN DAINCYRELY NEKKRRSKQL
S
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