ID A0A5F5XPA6_FELCA Unreviewed; 205 AA.
AC A0A5F5XPA6;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 18-JUN-2025, entry version 24.
DE RecName: Full=BH3-interacting domain death agonist {ECO:0000256|ARBA:ARBA00015802, ECO:0000256|PIRNR:PIRNR038018};
GN Name=BID {ECO:0000313|Ensembl:ENSFCAP00000055705.1,
GN ECO:0000313|VGNC:VGNC:60115};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000055705.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000055705.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000055705.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000055705.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000055705.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000055705.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000055705.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- FUNCTION: Induces caspase activation and apoptosis. Allows the release
CC of cytochrome c. {ECO:0000256|ARBA:ARBA00055577}.
CC -!- FUNCTION: Induces caspases and apoptosis. Counters the protective
CC effect of BCL2. {ECO:0000256|ARBA:ARBA00057135,
CC ECO:0000256|PIRNR:PIRNR038018}.
CC -!- SUBUNIT: Forms heterodimers either with the pro-apoptotic protein BAX
CC or the anti-apoptotic protein BCL2. Interacts with PLEKHN1.
CC {ECO:0000256|ARBA:ARBA00063031}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR038018}.
CC Mitochondrion outer membrane {ECO:0000256|PIRNR:PIRNR038018}.
CC -!- DOMAIN: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for
CC their pro-apoptotic activity and for their interaction with anti-
CC apoptotic members of the Bcl-2 family. {ECO:0000256|PIRNR:PIRNR038018}.
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DR EMBL; AANG04001873; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A5F5XPA6; -.
DR STRING; 9685.ENSFCAP00000055705; -.
DR Ensembl; ENSFCAT00000076887.1; ENSFCAP00000055705.1; ENSFCAG00000011109.6.
DR VGNC; VGNC:60115; BID.
DR GeneTree; ENSGT00390000002868; -.
DR InParanoid; A0A5F5XPA6; -.
DR OMA; DMDHSIH; -.
DR Proteomes; UP000011712; Chromosome B4.
DR Bgee; ENSFCAG00000011109; Expressed in adult mammalian kidney and 10 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0008637; P:apoptotic mitochondrial changes; IBA:GO_Central.
DR GO; GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IBA:GO_Central.
DR FunFam; 1.10.437.10:FF:000010; BH3-interacting domain death agonist; 1.
DR Gene3D; 1.10.437.10; Blc2-like; 1.
DR InterPro; IPR036834; Bcl-2-like_sf.
DR InterPro; IPR010479; BID.
DR PANTHER; PTHR35447; BH3-INTERACTING DOMAIN DEATH AGONIST; 1.
DR PANTHER; PTHR35447:SF1; BH3-INTERACTING DOMAIN DEATH AGONIST; 1.
DR Pfam; PF06393; BID; 1.
DR PIRSF; PIRSF038018; BID; 1.
DR SUPFAM; SSF56854; Bcl-2 inhibitors of programmed cell death; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703, ECO:0000256|PIRNR:PIRNR038018};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR038018};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038018};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787,
KW ECO:0000256|PIRNR:PIRNR038018};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
SQ SEQUENCE 205 AA; 23544 MW; C3B9A64845E5F3F3 CRC64;
MDSQVSNGSS LQDEHITNLL VFGFLQNCSN YNFHKELEVL GRELPVPPAY LQEDHDDGLQ
TDGNRCSRFL DSEETDSESQ EEIIQDIARQ LAQIGDRMDH SIHPRVVNNL AMQFMNVNLS
EEDRRKHLAA ALEQVLQTYP KDMEREKTVL MLAMVLAKKV ADHTPSLLRD VFRTTVNFIN
QNLLTYVRNL VRNVRTSDVT SLAFR
//
