ID A0A5F5XPB0_FELCA Unreviewed; 780 AA.
AC A0A5F5XPB0;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 18-JUN-2025, entry version 25.
DE RecName: Full=Granulocyte colony-stimulating factor receptor {ECO:0000256|ARBA:ARBA00071023};
GN Name=CSF3R {ECO:0000313|Ensembl:ENSFCAP00000056056.1,
GN ECO:0000313|VGNC:VGNC:61217};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000056056.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000056056.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000056056.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000056056.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000056056.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000056056.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000056056.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBUNIT: Homodimer. The dimeric receptor binds two CSF3 molecules.
CC Interacts with CEACAM1; down-regulates the CSF3R-STAT3 pathway through
CC recruitment of PTPN6 that dephosphorylates CSF3R.
CC {ECO:0000256|ARBA:ARBA00066227}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 3
CC subfamily. {ECO:0000256|ARBA:ARBA00010890}.
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DR EMBL; AANG04003369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A5F5XPB0; -.
DR Ensembl; ENSFCAT00000080246.1; ENSFCAP00000056056.1; ENSFCAG00000013269.6.
DR VGNC; VGNC:61217; CSF3R.
DR GeneTree; ENSGT00940000158915; -.
DR Proteomes; UP000011712; Chromosome C1.
DR Bgee; ENSFCAG00000013269; Expressed in spleen and 9 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR FunFam; 2.60.40.10:FF:000879; Colony stimulating factor 3 receptor; 1.
DR FunFam; 2.60.40.10:FF:001209; Colony stimulating factor 3 receptor; 1.
DR FunFam; 2.60.40.10:FF:001234; Colony stimulating factor 3 receptor; 1.
DR FunFam; 2.60.40.10:FF:000997; Colony stimulating factor 3 receptor (Granulocyte); 1.
DR FunFam; 2.60.40.10:FF:000465; Granulocyte colony-stimulating factor receptor; 1.
DR FunFam; 2.60.40.10:FF:000839; granulocyte colony-stimulating factor receptor isoform X1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010457; IgC2-like_lig-bd.
DR InterPro; IPR050379; Type-I_Cytokine_Rcpt.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF103; GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF06328; Lep_receptor_Ig; 1.
DR SMART; SM00060; FN3; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..780
FT /note="Granulocyte colony-stimulating factor receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023869171"
FT TRANSMEM 626..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 125..230
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 236..332
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 431..525
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 527..624
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 733..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 780 AA; 86358 MW; 33AECFD87721E0C3 CRC64;
MVELGTWSLT RAALIILLLP RSLEECGHIS LPTSAVRLGD SITASCTISP NCSHLGPESQ
ILWKLGTQLQ LGERQQRLAD GSQESTITLP PLNRPRDLLS CCLRWGNSVQ ILDQAELWAG
YPPAAPHNLS CLMNLTTNSL ICQWEPGPHN HLPTNFTLKS FKSRDNCQTQ EDSILDCVPK
DGDSHCSIPR KYLKLYRHMG IWVQAENALG TGKSPQLCLV PMDVVKLEPP TLWALAPSPE
VAPPQPGCLL LRWELWKPSL YIEQKCELRH QPQLGEASWA LVGPLLPETL QYELCGLLPS
TAYVLQMRCV RWPLPGQWSD WSPSLILTTA QQAPIVRLDT WWRQRQLDPR TVDVQLFWKP
VPLDKYSGQI QGYLVRPPGQ TGAVPALCNT TELSCTFHLP SEAREVVLVA YNTAGTSHPT
PVVFLESRGP PLARLHTTAR DPHSLWVGWE PPSPRPRGYV IAWGLGPPSP SSSNMTWKME
HNGNISGTLL QENIRPFQLY EITVTPLYQD TVGPSQHIYA YSQEMAPSHT PELHLKHIGK
TWAQLEWEPQ APELGKSPLT HYTVFWTNAQ DQSFFTTLNA SSHGLVLHGL EPASLYHVCL
MASSKAGATN STSLTLMTLA LEESELHILL GLFGLLVLLI CLCGASRFCC RPSRKNPLWP
SVPDPAHSSL GSWVPTIMVE EAFQLPSLRD PGMPPITKIT VLEEEEKKPG PWESNDSSGT
CGLPTLVQAY VLQGDPRTPS TQPQPPSSTN DQGPSSDGGT YQNCSFVYSF LRSLIPPAHT
//
