ID A0A5F5XPJ8_FELCA Unreviewed; 624 AA.
AC A0A5F5XPJ8;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 18-JUN-2025, entry version 27.
DE SubName: Full=FMR1 autosomal homolog 2 {ECO:0000313|Ensembl:ENSFCAP00000056146.1};
GN Name=FXR2 {ECO:0000313|Ensembl:ENSFCAP00000056146.1,
GN ECO:0000313|VGNC:VGNC:99059};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000056146.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000056146.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000056146.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000056146.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000056146.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000056146.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000056146.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule
CC {ECO:0000256|ARBA:ARBA00004331}.
CC -!- SIMILARITY: Belongs to the FMR1 family.
CC {ECO:0000256|ARBA:ARBA00006633}.
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DR EMBL; AANG04000740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A5F5XPJ8; -.
DR Ensembl; ENSFCAT00000077840.1; ENSFCAP00000056146.1; ENSFCAG00000009620.5.
DR VGNC; VGNC:99059; FXR2.
DR GeneTree; ENSGT00950000183189; -.
DR Proteomes; UP000011712; Chromosome E1.
DR Bgee; ENSFCAG00000009620; Expressed in prefrontal cortex and 10 other cell types or tissues.
DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:UniProtKB-SubCell.
DR GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR GO; GO:0006417; P:regulation of translation; IEA:InterPro.
DR CDD; cd22505; KH_I_FXR2_rpt1; 1.
DR CDD; cd22508; KH_I_FXR2_rpt2; 1.
DR CDD; cd22511; KH_I_FXR2_rpt3; 1.
DR FunFam; 2.30.30.140:FF:000001; Fragile X mental retardation 1, isoform CRA_e; 1.
DR FunFam; 3.30.1370.10:FF:000004; Fragile X mental retardation 1, isoform CRA_e; 1.
DR FunFam; 3.30.1370.10:FF:000017; Fragile X mental retardation syndrome-related protein 1; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR008395; Agenet-like_dom.
DR InterPro; IPR040148; FMR1.
DR InterPro; IPR022034; FMR1-like_C_core.
DR InterPro; IPR040472; FMRP_KH0.
DR InterPro; IPR032172; FXR1_C1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR047422; KH_I_FXR2_rpt1.
DR InterPro; IPR047424; KH_I_FXR2_rpt2.
DR InterPro; IPR041560; Tudor_FRM1.
DR PANTHER; PTHR10603; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN; 1.
DR PANTHER; PTHR10603:SF3; RNA-BINDING PROTEIN FXR2; 1.
DR Pfam; PF05641; Agenet; 1.
DR Pfam; PF12235; FXMRP1_C_core; 1.
DR Pfam; PF16096; FXR_C1; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF17904; KH_9; 1.
DR SMART; SM00322; KH; 2.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR PROSITE; PS51641; AGENET_LIKE; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00117}.
FT DOMAIN 14..76
FT /note="Agenet-like"
FT /evidence="ECO:0000259|PROSITE:PS51641"
FT REGION 340..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..433
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..486
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..546
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 68539 MW; 85E39ED68F895DF4 CRC64;
MGGLASGGDV EPGLPVEVRG SNGAFYKVYS RANEQEPCGW WLARVRMMKG DFYVIEYAAC
DATYNEIVTL ERLRPVNPNP LATKGSFFKV TMAVPEDLRE ACSNENVHKE FKKALGANCI
FLNITNSELF ILSTTEAPVK RASLLGDMHF RSLRTKLLLM SRNEEATKHL ETSKQLAAAF
QEEFTVREDL MGLAIGTHGA NIQQARKVPG VTAIELGEET CTFRIYGETP EACRQARSYL
EFSEDSVQVP RNLVGKVIGK NGKVIQEIVD KSGVVRVRVE GDNDKKNPRE EGMVPFIFVG
TRENISNAQA LLEYHLSYLQ EVEQLRLERL QIDEQLRQIG LGFRPPGSGR GSGGSDKAGY
TTDESSSSSL HTTRTYGGSY GGRGRGRRTG GPAYGPSSDP STASETESEK REEPNRAGPG
DRDPPTRGEE SRRRPIGGRG RGPPPAPRPT TRYNASSISS VLKDPDSNPY SLLDTSEPEP
PVDSEPGEPP PASARRRRSR RRRTDDDRTV MDGGLESDGP SMTENGLEDE SRPQRRNRSR
RRRNRGNRTD GSISGDRQPV TVADYISRAE SQSRQRPPLE RTKPSEDSLS GQKGDSVSKL
PKGPSENGEL SAPLELGSLV NGVS
//
