ID A0A5F5XY38_FELCA Unreviewed; 1252 AA.
AC A0A5F5XY38;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 18-JUN-2025, entry version 24.
DE SubName: Full=ALF transcription elongation factor 1 {ECO:0000313|Ensembl:ENSFCAP00000059075.1};
GN Name=AFF1 {ECO:0000313|Ensembl:ENSFCAP00000059075.1,
GN ECO:0000313|VGNC:VGNC:68271};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000059075.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000059075.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000059075.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000059075.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000059075.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000059075.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000059075.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
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DR EMBL; AANG04001605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A5F5XY38; -.
DR STRING; 9685.ENSFCAP00000059075; -.
DR PaxDb; 9685-ENSFCAP00000017028; -.
DR Ensembl; ENSFCAT00000073855.1; ENSFCAP00000059075.1; ENSFCAG00000029806.4.
DR VGNC; VGNC:68271; AFF1.
DR GeneTree; ENSGT00950000182974; -.
DR InParanoid; A0A5F5XY38; -.
DR OMA; KFTMSLK; -.
DR Proteomes; UP000011712; Chromosome B1.
DR Bgee; ENSFCAG00000029806; Expressed in uterus and 10 other cell types or tissues.
DR GO; GO:0032783; C:super elongation complex; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 6.10.250.2670; -; 1.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR043639; AF4_int.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF6; AF4_FMR2 FAMILY MEMBER 1; 1.
DR Pfam; PF05110; AF-4; 1.
DR Pfam; PF18875; AF4_int; 1.
DR Pfam; PF18876; AFF4_CHD; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 997..1251
FT /note="AF4/FMR2 C-terminal homology"
FT /evidence="ECO:0000259|Pfam:PF18876"
FT REGION 49..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 819..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1143..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..265
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..313
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..472
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..486
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..505
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..530
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..593
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..713
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..794
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..851
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..881
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..931
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1145..1172
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1252 AA; 135085 MW; 4DCC8EC0F250B7A4 CRC64;
MAQSIKWCLT SGSLTFQHAP VTLGQQWSTT SQSLYNEDRN LLRIREKERR NQEAHQEKEA
FPEKIPLFGE PYKTEKGDEL SSRIQNMLGN YEEMKEFLST KSHPHRLDAS ENRLGKPRYP
SFPEKGSSIP PHPFHTSAHH QPINTPASGP LPVGNISHNP KMAQPRMEPM SNPHVRGYGP
PDSQHLTQDR LGQEGCGSAH HKKGDRRADG DRCTLVTDSA PERELSPLLS LPSPVAPLSP
VHSNQQTLPR TQGSNKVHSS NSNNKGYCPA KSPKDLVVKV HDKETPQDSL VAVASLGVAP
PQPPSQTFPP PSLPSKTVAM QQKPTAYVRP MDGQDQAPSE SPELKPLPED YRQQTFEKTD
LKVPAKAKLT KLKMPSQSVE QTYSNEVHCV EEILKEMTHS WPPPLTAIHT PSTAEPSKFP
FPTKDSQHIS SATQNQKQYD TSSKNHTNSQ QGTSMLEDDL QLSDSEDSDN EQSPEKPPSA
SAPPSAPQSL PEAAASAHSS SAESESTSDS DSSSDSESES SSSDSEENEP LETPAPEPEP
PTTNKWQLDN WLTKVSQPAA APDALGSAEP PPRHPESKGK GGGDGGGGGG GGAASHERSE
SKDPALKSSG KGPRGPSEGL HAGKRSCQKS PAQQEAPQRQ TVGNKQPKKP VKAPAQADSR
ASLQVESEPG PPPYGSKDQP SKDKPKVKTK GRPRAGDGRE PKPVAPGPSP SPSPSERKKH
RSGPLAPSKA LSGPEPTKDN VGARSPEHFA LVPLTQSQGP PQGGGGRTSG CRRAVVVQED
RRKDRLPGPT RDPKLLSPLR DTAPPPILMV KITLDLLSRI PQLPGKGGRQ KRPEDKQPAT
GKKPDPEKRG ADSSSKLAKK RKGDTEKDHD SKKARLEKET KSQPSCSSSH KDSSKTKTPR
PSSEPSKKEM LSPQLVSSSS SSSSSQKPAK PAQKRPKREA DQDPPQSASS SKGSHKDSSA
PKHRRVEGKG SGSCTEHKGS SGDTANPFLV PSLPNGNSKP GKPPVKLDRQ QADFHMKEAK
KLKQRAELMT DKVGKAFKYL EAALSFIECG IAMESESPAS QSAYSVYSET VDLIKFIMSL
KSFSDASAPQ EKILAVLCMR CQSILNMAMF RCKKDIAIKY SRALNEHFSS FFKVAQAPSP
CVARSTGTPS PLSPMPSSAS SMGSQSSAGS IGSSGMPVTI QNMTSSYVTI TSHVLAAFDL
WEQAEVLTRK NKEFFAQLST SVCALALNSS LMDLVHYTRQ GFHRLKQATK TP
//
