ID A0A5F5Y4T6_FELCA Unreviewed; 1372 AA.
AC A0A5F5Y4T6;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 18-JUN-2025, entry version 22.
DE SubName: Full=Calmodulin regulated spectrin associated protein family member 2 {ECO:0000313|Ensembl:ENSFCAP00000061153.1};
GN Name=CAMSAP2 {ECO:0000313|Ensembl:ENSFCAP00000061153.1,
GN ECO:0000313|VGNC:VGNC:60342};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000061153.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000061153.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000061153.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000061153.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000061153.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000061153.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000061153.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
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DR EMBL; AANG04001043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSFCAT00000070048.1; ENSFCAP00000061153.1; ENSFCAG00000004594.6.
DR VGNC; VGNC:60342; CAMSAP2.
DR GeneTree; ENSGT00950000182975; -.
DR Proteomes; UP000011712; Chromosome F1.
DR Bgee; ENSFCAG00000004594; Expressed in brain and 10 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0030507; F:spectrin binding; IEA:InterPro.
DR GO; GO:0031175; P:neuron projection development; IEA:InterPro.
DR InterPro; IPR032940; CAMSAP.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR031372; CAMSAP_CC1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR PANTHER; PTHR21595:SF1; CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 2; 1.
DR PANTHER; PTHR21595; PATRONIN; 1.
DR Pfam; PF17095; CAMSAP_CC1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR PROSITE; PS50021; CH; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 222..335
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 388..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 927..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1034..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1193..1230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1249..1290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1304..1372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 763..790
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 890..927
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 391..403
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..417
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..701
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..715
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 952..991
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1041..1077
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1080..1106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1107..1119
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1134..1154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1345..1357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1372 AA; 154993 MW; 54287D3D9DDD6A1E CRC64;
MGDAADPREM RKTFIVPAIK PFDHYDFSRA KIACNLAWLV AKAFGTENVP EELREPFYTD
QYDQEHIKPP VVNLLLSAEL YCRAGSLILK SDAAKPLLGH DAVIQALAQK GLYVTDQEKL
VTERDLHKKP IQMSAHLAMI DTLMMAYTVE MVSIEKVIAC AQQYSAFFQA TDLPYDIEDA
VMYWINKVNE HLKDIMEQEQ KLKEHHTVEA PGGQKSPSKW FWKLVPARYR KEQTLLKQLP
CIPLVENLLK DGTDGCALAA LIHFYCPGVV RLEDICLKET MSLADSLYNL QLIQEFCQEY
LNQCCHFTLE DMLYAASSIK SNYLVFMAEL FWWFEVVKPS FVQPRVVRPQ GAEPMNDMPS
VPVLNAAKTN IVDGSCSSDF TSSGEGAAFT HSHHHLPSRH SHPQAHSSAS GGIRRSSSMS
YVDGFIGTWP KEKRSSVHGV SFDISFDKEN TVHRSTPNRG ITRSISNEGL TLNNNRVSKN
IRKNLSFKPV NGEEEAESIE EELNTDCHSD LKSYMPLNTN ELNSNENIHY KLPNGALQNR
VLLDEFGNQI ETPSIEEALQ IIHDTEKSPH TSQPDQIANG FFLHNQEVSI LNSNIKLNQS
SPDNITDTKG ALSPITDNTE VDTGIHVPSE DIPETMDEDS SLRDYTVSLD SDMDDASKFL
QDYDIRTCNP REALSPCPST VSTKSQPGSS ASSSSGVKMT SFAEQKFRKL NHTDGKSSGS
SSQKTTPEGS ELNIPHVVAW GQIPEETGLP QGRDTTQLLA SEMVHLRMKL EEKRRAIEAQ
KKKMEAAFTK QRQKMGRTAF LTVVKKKGEG ISPLREEAAG AEDEKVYTDR AKEKDLQKAN
GQRSKSLADI KESMENPQAK WLKSPTTPVD PEKQWNLASP SEETLNESEI LEYTKSIEKL
NSSLHFLQQE MQRLSLQQEM LMQMREQQSW VISPPQPSPQ KQIRDFKPSR QAGLSSTIAP
FSSDSPRPTH PSPQSSNRKS TSFSVKNQRT PRPNELKITP LNRTLTPPRS VDSLPRLRRF
SPSQVPIQTR SFVCFGDDGE PQLKESKPKE EVKKEELEPR GTLGEHVHNP EEKEIKPLES
TVSEVLSQPI TETVRLTPNE DQLNQPSEPP PKPVFPPAAP KNVNLIEVSL SDLKPPEKTD
VSVEKYDGES DKEQFDDDQK VCCGFFFKDD QKAENDMAMK RAALLEKRLR REKETQLRKQ
QLEAEMEHKK EETRRKTEEE RQKKEDERAR REFIRQEYMR RKQLKLMEDM DTVIKPRPQI
AKQKKQRPKS IHRDHIESPK TPIKGPPGSR IYRVFSVSSL SLASLNTGDN ESVHSGKRTP
RSESVEGFLS PSRCGSRNGE KDWENASTTS SVASGTEYTG PKALQRTQCK IQ
//
