ID A0A5F5Y7S6_FELCA Unreviewed; 2130 AA.
AC A0A5F5Y7S6;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 18-JUN-2025, entry version 25.
DE RecName: Full=Calcineurin-binding protein cabin-1 {ECO:0000256|ARBA:ARBA00071005};
DE AltName: Full=Calcineurin inhibitor {ECO:0000256|ARBA:ARBA00078627};
GN Name=CABIN1 {ECO:0000313|Ensembl:ENSFCAP00000062188.1,
GN ECO:0000313|VGNC:VGNC:60283};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000062188.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000062188.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000062188.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000062188.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000062188.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000062188.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000062188.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AANG04002472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSFCAT00000068105.1; ENSFCAP00000062188.1; ENSFCAG00000009409.6.
DR VGNC; VGNC:60283; CABIN1.
DR GeneTree; ENSGT00390000008529; -.
DR Proteomes; UP000011712; Chromosome D3.
DR Bgee; ENSFCAG00000009409; Expressed in prefrontal cortex and 10 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:InterPro.
DR CDD; cd13839; MEF2_binding; 1.
DR FunFam; 1.25.40.10:FF:000654; Calcineurin-binding protein 1; 1.
DR FunFam; 1.25.40.10:FF:000076; calcineurin-binding protein cabin-1 isoform X1; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR033053; Hir3/CABIN1.
DR InterPro; IPR015134; MEF2-bd.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_rpt.
DR PANTHER; PTHR15502; CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED; 1.
DR PANTHER; PTHR15502:SF7; CALCINEURIN-BINDING PROTEIN CABIN-1; 1.
DR Pfam; PF09047; MEF2_binding; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 90..123
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 2066..2100
FT /note="Calcineurin-binding protein cabin-1 MEF2-binding"
FT /evidence="ECO:0000259|Pfam:PF09047"
FT REGION 361..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1299..1401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1607..1792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1857..2075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2107..2130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1301..1324
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1327..1349
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1655..1664
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1683..1692
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1723..1733
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1758..1767
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1909..1928
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1929..1942
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2004..2021
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2117..2130
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2130 AA; 236411 MW; B98ED1BC63FA3D54 CRC64;
MIRIAALNAS STVEDDHEGS FKSHKTQTKE AQEAEAFALY HKALDLQKHD RFEESAKAYH
ELLEARLLRE AVSSGDEKEG LKHPGLMLKY STYKNLAQLA AQREDLETAM EFYLEAVMLD
STDVNLWYKI GHVALRLIRV PLARHAFEEG LRCNPDHWPC LDNLITVLYT LSDYTTCLYF
ICKALEKDCR YSKGLVLKEK IFEEQPCLRK DSLRMFLKCD MSIHDVSVSA AETKAIVEEA
LGLRKKRQAL TVREKEPDLK LVQPIPFFTW KCLGESLLAM YNHLTTCEPL RPSLGKRIDL
SDYQDPSQPL VSSVVVAPVS VIQPSPVPAN PAVTVAEPVL SYAPVAAASF PLHSPSLLET
GVPAGDVSGG DKSKKGVKRK KIAEESGETA KRRSARVRNT KCKKEEKVDF QELLMKFLPS
RLRKLDPEEE DDPFNTYEVQ SEAKLQSFPN IGPHRLSFDS ATFMESEKQD VHAFLLENLT
NGGILELMMR YLKGMGHKFL LRWPPGLAEV VLSIYHSWRR HSTSLPNPLL RDCSNKHIKD
MMLMSLSCME LQLDQWLLTK GRSSAVSPRS CPAGVVNGRF GPDFPGTHFL GDLLQLSFAS
SQRDLFEDGW LEFVVRVYWL KARFLALQGD MEQALENYDI CTEMLQSSTA IQAEAGVEQR
DLVIRLPNLY NDSVVSLEEI DKNLKSLERC QSLEEIQRLY EAGDYKAVVH LLRPTLCTSG
FDRAKHLEFM TSIPERPAQL LLLQDSLLRL KDHRQCFECS DVALQEAVQQ MVNASESAAK
EEWVATVTQL LLGIEQALSA DSSGSILKES SSSTGLTRLT NNLIQVIDCS MAVQEEPKEP
HVSSVLPWII LHRIIWQEED TFHSLCHQQQ LQNPTDEVMA ETPMLPSSLM LLNTAHEYLG
RRSWCCNSDG ALLRFYVRVL QKELAASTSE DTHPYKEELE TALEQCFYCL YSFPSKKSKA
RYLEEHSAQQ VDLIWEDALF MFEYFKPKTL PEFDSYKTST VSADLANLLK RIATIVPRTE
RPALNLDKVS AYIEGTSAEV PCLPEGADPS PPVVNELYYL LADYHFKNKE QSKAIKFYMH
DICICPNRFD SWAGMALARA SRIQDKLNSN ELKSDGPIWK HATPVLNCFR RALEIDSSNL
SLWIEYGTMS YALHSFASRQ LKQWRAELPP ELVQQMEGRR DSMLETARHC FTSAARCEGD
GDEEEWLIHY MLGKVAEKQQ QPPAVYLLHY RQAGHYLHEE AARYPKKIHY HNPPELAMEA
LEVYFRLHAS ILKLLGKPDS GVSAEVLVNF MKEAAEGPFA RGEEKNTPKA SEKEKACLVD
EDSHSSAGTL PGPGASLPSS SGPGLTSPPY TATPIDHDYV KCKKPHQQAT PDGKTEESLE
STEGFRATEQ GSQKPAADPP ASACIAAKLP ASAPALWDGR KRADTLGEPA AFPQGLPAGA
EEQRQFLTEQ CIASFRLCLS RFPQHYKSLY RLAFLYTYSK THRNLQWARD VLLGSGIPWQ
QLQHMPAQGL FCERNKTNFF NGIWRIPVDE IDRPGSFAWH MNRSIVLLLK VLAQLRDHST
LLKVSSMLQR TPDQGKKYLR DADRQVLAQR AFILTVKVLE DTLSELAEGS ERPGPKACGL
PGGRMTTDVP HKASPEDSQE ALPHSKKPPL ADGSGPAGEP GGKVGPLNHR PVAMEAGDSA
DQSGERKDRE SPRAGPTEPM DTGEATTRCS DSERAPPPQP GRPPRDRGPE SRPTELSLEE
LSISARQQPS PLTPAQPAPA TTPAATTGAR VGSHPEEPPT RPSRKRKLLE DTESGKTLLL
DAYRVWQQGQ KGMAYDLGRI ERIMSETYML IKQVDEEAAL EQAVKFCQVH LGAAAQRQAA
GDTPTTPKHP KDSRENFFPG AGAPTVPDPV PADTLQRPGD THNKPRPVPA ATTAIIPCPP
SASASSPDPS KDPGHPRPHR AEATPSMTSL GPDGEELAGG AEGTGFTPQE PLHGEQVKTV
PDSPSAEPHC WPPEAAPRTG AEPTCSQVTS SKVPSGASAQ SPEGPPSKAE PGRAKSRLLP
SMPKLVIPSA ATKFPPEITV TPPTPTLLSP KGSISEETKQ KLKSAILSAQ SAANVRKESL
CQPALEVLET SSQESSLESE TDEDDDYMDI
//
