ID A0A5F9D806_RABIT Unreviewed; 797 AA.
AC A0A5F9D806;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 18-JUN-2025, entry version 26.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN Name=STAT1 {ECO:0000313|Ensembl:ENSOCUP00000042339.1};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000042339.1, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000042339.1, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000042339.1,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000042339.1}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000042339.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR EMBL; AAGW02003464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A5F9D806; -.
DR Ensembl; ENSOCUT00000035540.1; ENSOCUP00000042339.1; ENSOCUG00000002455.4.
DR GeneTree; ENSGT01050000244905; -.
DR Proteomes; UP000001811; Chromosome 7.
DR Bgee; ENSOCUG00000002455; Expressed in blood and 17 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd10372; SH2_STAT1; 1.
DR CDD; cd16851; STAT1_CCD; 1.
DR CDD; cd16845; STAT1_DBD; 1.
DR FunFam; 1.10.238.10:FF:000012; Signal transducer and activator of transcription; 1.
DR FunFam; 1.20.1050.20:FF:000001; Signal transducer and activator of transcription; 1.
DR FunFam; 2.60.40.630:FF:000001; Signal transducer and activator of transcription; 1.
DR FunFam; 3.30.505.10:FF:000003; Signal transducer and activator of transcription; 1.
DR FunFam; 6.10.250.3310:FF:000001; Signal transducer and activator of transcription; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 6.10.250.3310; signal transducer and activator of transcription 1; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR038295; STAT1_C_sf.
DR InterPro; IPR035859; STAT1_SH2.
DR InterPro; IPR022752; STAT1_TAZ2-bd_C.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12162; STAT1_TAZ2bind; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 620..717
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 200..230
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 797 AA; 92197 MW; F895289E99C3C776 CRC64;
MYYLLTAKGV NMLKVFDIDN EDSGFLFCFS FGAVHHEQFP AQSLQVLEFF TLIACTGKPF
KLLLQGRKCH LKNHFPVIAI KKAVFVLSAL SSIWNETRTF SIPREHAAND VSFATILFHD
LLSQLDDQYS RFSLENNFLL QHNIRKSKRN LQDNFQEDPI QMSMIIYNCL KEERKILENA
QRFNQAQSGN IQSTVMLDKQ KELDNKVRNV KEQVMNIEHE IKTLEDLQDE YDFKCKTLQN
REHEANGVAK SDQKQEQLLL QKMYLMLDNK RKEIVHKMRE LLNATELTQN ALINDELVEW
KRRQQSACIG GPPNACLDQL QNWFTIVAES LQQVRQQLKK LEELEQKFTY EHDPITKNKQ
VLWDRTFSLF QQLIQSSFVV ERQPCMPTHP QRPLVLKTGV QFTVKLRLLV KLQELNYNLK
VKVLFDKDVN ERNTVKGFRK FNILGTHTKV MNMEESTNGS LAAEFRHLGP LIVTEELHSL
SFETQLCQPG LVIDLETTSL PLVVISNVSQ LPSGWASILW YNMLVAEPRN LSFFLNPPCA
RWSQLSEVLS WQFSSVTKRG LNGDQLSMLG EKLLGPNAGL DGLIPWTRFC KENISDKNFS
FWLWIENILE LIKKHLLCLW NDGCIMGFIS KERERALLKD QQPGTFLLRF SESSREGAIT
FTWVERSQNG GEPYFHAVEP YTKKELSAVT FPDIIRNYKV MAAENIPENP LKYLYPNIDK
DHAFGKYYSR PKEGQEPMEL DGPKGTGYIK TELISVSEVH PSRLQSTENL LPMSPEEFDE
VSRIMGPVEF DSMMNAV
//
