ID A0A5G2Q826_PIG Unreviewed; 336 AA.
AC A0A5G2Q826;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 18-JUN-2025, entry version 27.
DE SubName: Full=Asialoglycoprotein receptor 2 {ECO:0000313|Ensembl:ENSSSCP00000060309.1};
GN Name=ASGR2 {ECO:0000313|Ensembl:ENSSSCP00000060309.1,
GN ECO:0000313|VGNC:VGNC:85576};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000060309.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000060309.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000060309.1};
RX PubMed=32543654;
RA Warr A., Affara N., Aken B., Beiki H., Bickhart D.M., Billis K., Chow W.,
RA Eory L., Finlayson H.A., Flicek P., Giron C.G., Griffin D.K., Hall R.,
RA Hannum G., Hourlier T., Howe K., Hume D.A., Izuogu O., Kim K., Koren S.,
RA Liu H., Manchanda N., Martin F.J., Nonneman D.J., O'Connor R.E.,
RA Phillippy A.M., Rohrer G.A., Rosen B.D., Rund L.A., Sargent C.A.,
RA Schook L.B., Schroeder S.G., Schwartz A.S., Skinner B.M., Talbot R.,
RA Tseng E., Tuggle C.K., Watson M., Smith T.P.L., Archibald A.L.;
RT "An improved pig reference genome sequence to enable pig genetics and
RT genomics research.";
RL Gigascience 9:0-0(2020).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000060309.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
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DR AlphaFoldDB; A0A5G2Q826; -.
DR SMR; A0A5G2Q826; -.
DR FunCoup; A0A5G2Q826; 175.
DR STRING; 9823.ENSSSCP00000060309; -.
DR Ensembl; ENSSSCT00000083727.2; ENSSSCP00000060309.1; ENSSSCG00000017932.6.
DR VGNC; VGNC:85576; ASGR2.
DR GeneTree; ENSGT00940000162310; -.
DR InParanoid; A0A5G2Q826; -.
DR Reactome; R-SSC-446203; Asparagine N-linked glycosylation.
DR Proteomes; UP000008227; Chromosome 12.
DR Bgee; ENSSSCG00000017932; Expressed in liver and 15 other cell types or tissues.
DR ExpressionAtlas; A0A5G2Q826; baseline.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005537; F:D-mannose binding; IBA:GO_Central.
DR GO; GO:0042806; F:fucose binding; IBA:GO_Central.
DR GO; GO:0038187; F:pattern recognition receptor activity; IBA:GO_Central.
DR GO; GO:0009100; P:glycoprotein metabolic process; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0055088; P:lipid homeostasis; IEA:Ensembl.
DR GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
DR CDD; cd03590; CLECT_DC-SIGN_like; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR050111; C-type_lectin/snaclec_domain.
DR InterPro; IPR033989; CD209-like_CTLD.
DR InterPro; IPR016187; CTDL_fold.
DR PANTHER; PTHR22803; MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF03954; Lectin_N; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 1: Evidence at protein level;
KW Lectin {ECO:0000256|ARBA:ARBA00022734}; Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A5G2Q826};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 177..294
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 336 AA; 38261 MW; 4B8608EA4E5B3E5D CRC64;
MARDFQDIQQ LDSEENDHQL GRGEGPGAGY RPKREDPIWK GTPLPQPLVL QRLCSKLRLS
LLVLGFNVLM LVAVCVVGSQ RTQLQMELQT LKETFSNFSS SLLMEMLTLS TRGGSAGDKV
TSLEAKMEKQ QQDLKADHAT LRLHLKHFPR DVRTLTCRLV FLQSNGTECC PVNWVDYEGS
CYWFSRSGKA WAEAEKYCQL ENAHLVVINS REEQKFIAQR TNPFQTWIGL TDSDGSWKWV
DGTDYGNGYK NWGALQPDDW QGHELGGSED CVEIQGDGRW NDDFCQQVKR WIEELGHPRF
IDSWCFRHKD QQDLGHLGGS DFAHLCPSAP GFFSQL
//
