ID A0A5G2QYQ2_PIG Unreviewed; 1085 AA.
AC A0A5G2QYQ2;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 18-JUN-2025, sequence version 3.
DT 18-JUN-2025, entry version 26.
DE RecName: Full=Transcription elongation factor SPT5 {ECO:0000256|ARBA:ARBA00020181, ECO:0000256|PIRNR:PIRNR036945};
GN Name=SUPT5H {ECO:0000313|Ensembl:ENSSSCP00000069273.3,
GN ECO:0000313|VGNC:VGNC:93625};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000069273.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000069273.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000069273.3,
RC ECO:0000313|Proteomes:UP000008227};
RX PubMed=32543654;
RA Warr A., Affara N., Aken B., Beiki H., Bickhart D.M., Billis K., Chow W.,
RA Eory L., Finlayson H.A., Flicek P., Giron C.G., Griffin D.K., Hall R.,
RA Hannum G., Hourlier T., Howe K., Hume D.A., Izuogu O., Kim K., Koren S.,
RA Liu H., Manchanda N., Martin F.J., Nonneman D.J., O'Connor R.E.,
RA Phillippy A.M., Rohrer G.A., Rosen B.D., Rund L.A., Sargent C.A.,
RA Schook L.B., Schroeder S.G., Schwartz A.S., Skinner B.M., Talbot R.,
RA Tseng E., Tuggle C.K., Watson M., Smith T.P.L., Archibald A.L.;
RT "An improved pig reference genome sequence to enable pig genetics and
RT genomics research.";
RL Gigascience 9:0-0(2020).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000069273.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SIMILARITY: Belongs to the SPT5 family. {ECO:0000256|ARBA:ARBA00006956,
CC ECO:0000256|PIRNR:PIRNR036945}.
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DR AlphaFoldDB; A0A5G2QYQ2; -.
DR SMR; A0A5G2QYQ2; -.
DR FunCoup; A0A5G2QYQ2; 3670.
DR GlyGen; A0A5G2QYQ2; 3 sites.
DR Ensembl; ENSSSCT00000075924.3; ENSSSCP00000069273.3; ENSSSCG00000023556.5.
DR Ensembl; ENSSSCT00000107128.1; ENSSSCP00000081522.1; ENSSSCG00000023556.5.
DR VGNC; VGNC:93625; SUPT5H.
DR GeneTree; ENSGT00440000037640; -.
DR Reactome; R-SSC-112382; Formation of RNA Pol II elongation complex.
DR Reactome; R-SSC-113418; Formation of the Early Elongation Complex.
DR Reactome; R-SSC-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-SSC-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR Reactome; R-SSC-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-SSC-72086; mRNA Capping.
DR Reactome; R-SSC-75955; RNA Polymerase II Transcription Elongation.
DR Reactome; R-SSC-77075; RNA Pol II CTD phosphorylation and interaction with CE.
DR Proteomes; UP000008227; Chromosome 6.
DR Bgee; ENSSSCG00000023556; Expressed in oocyte and 43 other cell types or tissues.
DR ExpressionAtlas; A0A5G2QYQ2; baseline.
DR GO; GO:0032044; C:DSIF complex; IBA:GO_Central.
DR GO; GO:0031090; C:organelle membrane; IEA:UniProtKB-ARBA.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0032785; P:negative regulation of DNA-templated transcription, elongation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0016239; P:positive regulation of macroautophagy; IEA:Ensembl.
DR GO; GO:0032968; P:positive regulation of transcription elongation by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06082; KOW_Spt5_2; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd06085; KOW_Spt5_5; 1.
DR CDD; cd06086; KOW_Spt5_6; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR FunFam; 2.30.30.30:FF:000013; Transcription elongation factor SPT5; 1.
DR FunFam; 2.30.30.30:FF:000016; Transcription elongation factor SPT5; 1.
DR FunFam; 2.30.30.30:FF:000017; Transcription elongation factor SPT5; 1.
DR FunFam; 3.30.70.940:FF:000003; Transcription elongation factor SPT5; 1.
DR Gene3D; 2.30.30.30; -; 3.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR041980; KOW_Spt5_6.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR006645; NGN-like_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR024945; Spt5_C_dom.
DR InterPro; IPR022581; Spt5_N.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF23042; KOW1_SPT5; 1.
DR Pfam; PF23284; KOW2_Spt5; 1.
DR Pfam; PF23291; KOW4_SPT5; 1.
DR Pfam; PF23290; KOW5_SPT5; 1.
DR Pfam; PF23288; KOW6_SPT5; 1.
DR Pfam; PF23287; KOW7_SPT5; 1.
DR Pfam; PF23037; KOWx_SPT5; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR Pfam; PF11942; Spt5_N; 1.
DR PIRSF; PIRSF036945; Spt5; 1.
DR SMART; SM01104; CTD; 1.
DR SMART; SM00739; KOW; 6.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE 1: Evidence at protein level;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036945};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A5G2QYQ2};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036945};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
SQ SEQUENCE 1085 AA; 120797 MW; DA0EFFD454738007 CRC64;
MSDSEDSNFS EEEDSERSSD GEEAEVEEER RSAAGSEKEE EPEEEEEEEE EEEYDEEEEE
EDDDRPPKKP RHGGFILDEA DVDDEYEDED QWEDGAEDIL EKEEIEASNI DNVVLDEDRS
GARRLQNLWR DQREEELGEY YMKKYAKSSV GETVYGGSDE LSDDITQQQL LPGVKDPNLW
TVKCKIGEER ATAISLMRKF IAYQFTDTPL QIKSVVAPEH VKGYIYVEAY KQTHVKQAIE
GVGNLRLGYW NQQMVPIKEM TDVLKVVKEV ANLKPKSWVR LKRGIYKDDI AQVDYVEPSQ
NTISLKMIPR IDYDRIKARM SLKDWFAKRK KFKRPPQRLF DAEKIRSLGG DVASDGDFLI
FEGNRYSRKG FLFKSFAMSA VITEGVKPTL SELEKFEDQP GIDLEVVTES TGKEREHNFQ
PGDNVEVCEG ELINLQGKIL SVDGNKITIM PKHEDLKDML EFPAQELRKY FKMGDHVKVI
AGRFEGDTGL IVRVEENFVI LFSDLTMHEL KVLPRDLQLC SETASGVDVG GQHEWGELVQ
LDPQTVGVIV RLERETFQVL NMYGKVVTVR HQAVTRKKDN RFAVALDSEQ NNIHVKDIVK
VIDGPHSGRE GEIRHLFRSF AFLHCKKLVE NGGMFVCKTR HLVLAGGSKP RDVTNFTVGG
FAPMSPRISS PMHPSAGGQR GGFGSPGGGG GGMSRGRGRR DNELIGQTVR ISQGPYKGYI
GVVKDATEST ARVELHSTCQ TISVDRQRLT TVGSRRPGGM TSTYGRTPMY GSQTPMYGSG
SRTPMYGSQT PLQDGSRTPH YGSQTPLHDG SRTPAQSGAW DPNNPNTPSR AEEEYEYAFD
DEPTPSPQAY GGTPNPQTPG YPDPSSPQVN PQYNPQTPGT PAMYNTDQFS PYAAPSPQGS
YQPSPSPQSY HQVAPSPGYQ NTHSPASYHP TPSPMAYQAS PSPSPVGYSP MTPGAPSPGG
YNPHTPGSGI EQNSSDWVTT DIQVKVRDTY LDTQVVGQTG VIRSVTGGMC SVYLKDSEKV
VSISSEHLEP ITPTKNNKVK VILGEDREAT GVLLSIDGED GIVRMDLDEQ LKILNLRFLG
KLLEA
//
