ID A0A5J5HX04_9BACI Unreviewed; 626 AA.
AC A0A5J5HX04;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 28-JAN-2026, entry version 27.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:KAA9025694.1};
GN ORFNames=F4V44_07315 {ECO:0000313|EMBL:KAA9025694.1};
OS Niallia endozanthoxylica.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae; Niallia.
OX NCBI_TaxID=2036016 {ECO:0000313|EMBL:KAA9025694.1, ECO:0000313|Proteomes:UP000326671};
RN [1] {ECO:0000313|EMBL:KAA9025694.1, ECO:0000313|Proteomes:UP000326671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MER_TA_151 {ECO:0000313|EMBL:KAA9025694.1,
RC ECO:0000313|Proteomes:UP000326671};
RA Seuylemezian A., Vaishampayan P.;
RT "Whole genome sequences of isolates from the Mars Exploration Rovers.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA9025694.1}.
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DR EMBL; VYKL01000015; KAA9025694.1; -; Genomic_DNA.
DR RefSeq; WP_150439349.1; NZ_VYKL01000015.1.
DR AlphaFoldDB; A0A5J5HX04; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000326671; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:KAA9025694.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000326671}.
FT DOMAIN 3..174
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 626 AA; 71678 MW; 634700E857135BB9 CRC64;
MNKRYFTIGM AGHIDHGKTT LTKALTNVDT DRLKEEKERN ISIELGFAPL YEDDEIQISV
VDVPGHERFI RQMIAGVAGI DLVVLVVAAD EGVMPQTREH LEILKFLGVK TGIIAITKID
RVDEELIEIV KEEIFDELKS TVFENAPYVL VDSVSHKGVE ELKSQIIVTL KEQEMRDIRG
AFRLPIDQVF TVKGQGTVVR GTVYEGAVSE GQVLTILPKG LSVRVRQIQV HHQLVQNVFA
GQRAALNLSG VTKEELERGD VLVSSEHFIV TKTIDVAMQV VSDLDYIVKQ RMPIKCHIGT
AEVMGRIVFF DRNSIETEND EVLCQLRLDE EIVTKRGDRF ILRRPTPKET IGGGWVIEPR
GEKYKFGYRT IEQMEQKKIG TAKERITAAL VEGKCLALSE LITMTSLSEE SILTELTGEE
FVLISKKEYT LQSIIETLLE EFIDKISYYH SQYPMKTGVN KAELFHPLQK EFPKALLEYV
LDSGVKRNQL LKKGQFVSLS TFIPHVPKNW QKRTENVLVK MQQDKYQVYY VIDYFKNEGI
PDYLINDIKH FLEEEGKIVS LDEQYYWHGD IFKVAVQRLK TETKSEFDIG EAKQILGLSR
KLMIPFLEKL DQLRLTKRAD NKRVWI
//
