ID A0A5N3X912_MUNRE Unreviewed; 906 AA.
AC A0A5N3X912;
DT 26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2020, sequence version 1.
DT 18-JUN-2025, entry version 17.
DE RecName: Full=Interleukin-6 receptor subunit beta {ECO:0000256|ARBA:ARBA00068277};
DE AltName: Full=Interleukin-6 signal transducer {ECO:0000256|ARBA:ARBA00078919};
DE AltName: Full=Membrane glycoprotein 130 {ECO:0000256|ARBA:ARBA00077050};
DE AltName: Full=Oncostatin-M receptor subunit alpha {ECO:0000256|ARBA:ARBA00083382};
DE Flags: Fragment;
GN ORFNames=FD755_018629 {ECO:0000313|EMBL:KAB0369636.1};
OS Muntiacus reevesi (Reeves' muntjac) (Cervus reevesi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Cervidae;
OC Muntiacinae; Muntiacus.
OX NCBI_TaxID=9886 {ECO:0000313|EMBL:KAB0369636.1, ECO:0000313|Proteomes:UP000326062};
RN [1] {ECO:0000313|EMBL:KAB0369636.1, ECO:0000313|Proteomes:UP000326062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCam_UCB_Mr {ECO:0000313|EMBL:KAB0369636.1};
RC TISSUE=Fibroblast cell line {ECO:0000313|EMBL:KAB0369636.1};
RA Mudd A.B., Bredeson J.V., Baum R., Hockemeyer D., Rokhsar D.S.;
RT "Discovery of a novel chromosome fission-fusion reversal in muntjac.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAB0369636.1}.
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DR EMBL; VCEB01000015; KAB0369636.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5N3X912; -.
DR Proteomes; UP000326062; Chromosome 15.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:TreeGrafter.
DR GO; GO:0043235; C:receptor complex; IEA:TreeGrafter.
DR GO; GO:0019955; F:cytokine binding; IEA:TreeGrafter.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 4.
DR FunFam; 2.60.40.10:FF:000281; Cytokine receptor like factor 1; 1.
DR FunFam; 2.60.40.10:FF:000414; Interleukin-6 receptor subunit beta; 1.
DR FunFam; 2.60.40.10:FF:000524; Interleukin-6 receptor subunit beta; 1.
DR FunFam; 2.60.40.10:FF:000542; Interleukin-6 receptor subunit beta; 1.
DR FunFam; 2.60.40.10:FF:000563; interleukin-6 receptor subunit beta; 1.
DR FunFam; 2.60.40.10:FF:000855; Interleukin-6 receptor subunit beta; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010457; IgC2-like_lig-bd.
DR InterPro; IPR050379; Type-I_Cytokine_Rcpt.
DR InterPro; IPR015321; TypeI_recpt_CBD.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF151; FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF09240; IL6Ra-bind; 1.
DR Pfam; PF06328; Lep_receptor_Ig; 1.
DR SMART; SM00060; FN3; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000326062};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..906
FT /note="Interleukin-6 receptor subunit beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5024293910"
FT TRANSMEM 609..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 212..312
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 317..415
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 507..601
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 648..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..731
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KAB0369636.1"
SQ SEQUENCE 906 AA; 102646 MW; 642141065DAEF712 CRC64;
FIFLYNLVLC ELIVPCAHIH PESSVVQIGS NFTAVCVLKE KCMDDYHVNA DDIFWKTSRA
TVSRDQYTVI NRTSSSVTFL NIPLINVLLT CNIRMFGQIN RSVYGIRIIS GLPPEKPENL
TCIVNEGKKM MCQWDLGRET HLETNYTLKS EWATEKFEDC KAKRDTPTSC TVDYPPVYFV
NIEVWVEAEN ALGKVASDHI NFDPIDKVKL NPPHILSVNN SKELSSILKL TWTDSRFKSF
ITLKYDIQYR TKDASTWNQV PPEDTSSTRS SFTVQDLKPF TEYVFRIRCM KEDGKGFWSD
WSEEASGITY EDRPSKAPSF WYKIEPSHAH GTRSVQLKWK TLPPFEANGK ILDYEVTLTR
WKSRLQNYTV QDTKLTVNLT NDRYVATLTA RNTVGKSDAS VLTIPAWDFQ ATHPVTDLKA
FPKDNVLWVE WTAPNEPVNR YILEWCVLSD KSPCIPDWQQ EDGTVHRTYL RGNLVESKCY
LITVTPVYAD GPGSPEHIKA YLKQAAPSKG PTVRTKKVGK NEAVLEWDQL PVDVQNGFIR
NYTIFYRTVI GNETAVNVDS SHTEYTLSSL TSDTLYMVRM AAYTDEGGKD GPEFTFTTPK
FAQGEIEAIV VPVCLAFLLT TLLGVLFCFN KRDLIKKHIW PNVPDPSKSH IAQWSPHTPP
RHFNSKDQMY PDGNFTDVSV VEIEANDKKP FPEDLKSLDL FKKEKVNTEG HSSGIGGSSC
MSSSRPSISS SDENESAQNT SSTVQYSTVV HSGYRHQVPS VQVFSRSEST QPLLDSEERP
EDLQLADNVD GSDSILPRQR YFKQNCSQHE TSPDISHFER SQQVPSVNEE DFVRLKQQQI
SDHISQPYGS GKMKMFQEVP AVDAFGPGIE GQVERFETVG MEAAVDEGMP KSYLPQTVRR
GGYMPQ
//
