ID A0A5N3XB87_MUNRE Unreviewed; 199 AA.
AC A0A5N3XB87;
DT 26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2020, sequence version 1.
DT 05-FEB-2025, entry version 19.
DE RecName: Full=Leukemia inhibitory factor {ECO:0000256|ARBA:ARBA00016836};
GN ORFNames=FD755_018311 {ECO:0000313|EMBL:KAB0370349.1};
OS Muntiacus reevesi (Reeves' muntjac) (Cervus reevesi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Cervidae;
OC Muntiacinae; Muntiacus.
OX NCBI_TaxID=9886 {ECO:0000313|EMBL:KAB0370349.1, ECO:0000313|Proteomes:UP000326062};
RN [1] {ECO:0000313|EMBL:KAB0370349.1, ECO:0000313|Proteomes:UP000326062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCam_UCB_Mr {ECO:0000313|EMBL:KAB0370349.1};
RC TISSUE=Fibroblast cell line {ECO:0000313|EMBL:KAB0370349.1};
RA Mudd A.B., Bredeson J.V., Baum R., Hockemeyer D., Rokhsar D.S.;
RT "Discovery of a novel chromosome fission-fusion reversal in muntjac.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: LIF has the capacity to induce terminal differentiation in
CC leukemic cells. Its activities include the induction of hematopoietic
CC differentiation in normal and myeloid leukemia cells, the induction of
CC neuronal cell differentiation, and the stimulation of acute-phase
CC protein synthesis in hepatocytes. {ECO:0000256|ARBA:ARBA00024822}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the LIF/OSM family.
CC {ECO:0000256|ARBA:ARBA00005971}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAB0370349.1}.
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DR EMBL; VCEB01000014; KAB0370349.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5N3XB87; -.
DR Proteomes; UP000326062; Chromosome 14.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005146; F:leukemia inhibitory factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0048861; P:leukemia inhibitory factor signaling pathway; IEA:TreeGrafter.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:TreeGrafter.
DR GO; GO:0010646; P:regulation of cell communication; IEA:UniProtKB-ARBA.
DR GO; GO:0045595; P:regulation of cell differentiation; IEA:TreeGrafter.
DR GO; GO:0023051; P:regulation of signaling; IEA:UniProtKB-ARBA.
DR FunFam; 1.20.1250.10:FF:000018; leukemia inhibitory factor; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR003624; Leukemia_IF.
DR InterPro; IPR001581; Leukemia_IF/oncostatin.
DR InterPro; IPR019827; Leukemia_IF/oncostatin_CS.
DR PANTHER; PTHR10633; LEUKEMIA INHIBITORY FACTOR; 1.
DR PANTHER; PTHR10633:SF0; LEUKEMIA INHIBITORY FACTOR; 1.
DR Pfam; PF01291; LIF_OSM; 1.
DR PRINTS; PR01883; LEUKAEMIAIF.
DR SMART; SM00080; LIF_OSM; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00590; LIF_OSM; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Reference proteome {ECO:0000313|Proteomes:UP000326062};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..199
FT /note="Leukemia inhibitory factor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5024417613"
SQ SEQUENCE 199 AA; 21920 MW; 73FB1C710212DD19 CRC64;
MRVRVVPLLL VLHWKQGAGS PLPITPVNAT CATRHPCPSN LMNQIRNQLG QLNSSANSLF
ILYYTAQGEP FPNNLDKLCG PNVTDFPPFH ANGTEKARLV ELYRIIAYLG ASLGNITRDQ
KVLNPYAHGL HSRLNATADV LRGLLSNVLC RLCSKYHVSH VDVTYGPDTS GKDVFQKKKL
GCQLLGKYKQ VIAVLAQAF
//
