ID   A0A5N5KT31_PANHP        Unreviewed;       730 AA.
AC   A0A5N5KT31;
DT   26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2020, sequence version 1.
DT   18-JUN-2025, entry version 21.
DE   RecName: Full=E3 UFM1-protein ligase 1 {ECO:0000256|ARBA:ARBA00019780};
DE   AltName: Full=E3 UFM1-protein transferase 1 {ECO:0000256|ARBA:ARBA00031516};
GN   ORFNames=PHYPO_G00130670 {ECO:0000313|EMBL:KAB5533346.1};
OS   Pangasianodon hypophthalmus (Striped catfish) (Helicophagus hypophthalmus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Pangasiidae; Pangasianodon.
OX   NCBI_TaxID=310915 {ECO:0000313|EMBL:KAB5533346.1, ECO:0000313|Proteomes:UP000327468};
RN   [1] {ECO:0000313|EMBL:KAB5533346.1, ECO:0000313|Proteomes:UP000327468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Indonesia {ECO:0000313|EMBL:KAB5533346.1,
RC   ECO:0000313|Proteomes:UP000327468};
RC   TISSUE=Blood {ECO:0000313|EMBL:KAB5533346.1};
RA   Wen M., Zahm M., Roques C., Cabau C., Klopp C., Donnadieu C., Jouanno E.,
RA   Avarre J.-C., Campet M., Ha T.T.T., Dugue R., Lampietro C., Louis A.,
RA   Herpin A., Echchiki A., Berthelot C., Parey E., Roest-Crollius H.,
RA   Braasch I., Postlethwait J., Bobe J., Montfort J., Bouchez O., Begum T.,
RA   Schartl M., Guiguen Y.;
RT   "A chromosome-scale genome assembly of the striped catfish, Pangasianodon
RT   hypophthalmus.";
RL   Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the UFL1 family.
CC       {ECO:0000256|ARBA:ARBA00010789}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAB5533346.1}.
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DR   EMBL; VFJC01000023; KAB5533346.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A5N5KT31; -.
DR   Proteomes; UP000327468; Chromosome 22.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:TreeGrafter.
DR   GO; GO:0061666; F:UFM1 ligase activity; IEA:InterPro.
DR   GO; GO:1990592; P:protein K69-linked ufmylation; IEA:TreeGrafter.
DR   GO; GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:TreeGrafter.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:TreeGrafter.
DR   InterPro; IPR018611; Ufl1.
DR   InterPro; IPR056761; Ufl1-like_C.
DR   InterPro; IPR056580; Ufl1_dom.
DR   InterPro; IPR056579; Ufl1_N.
DR   PANTHER; PTHR31057; E3 UFM1-PROTEIN LIGASE 1; 1.
DR   PANTHER; PTHR31057:SF0; E3 UFM1-PROTEIN LIGASE 1; 1.
DR   Pfam; PF09743; E3_UFM1_ligase; 1.
DR   Pfam; PF23659; UFL1; 1.
DR   Pfam; PF25041; UFL1_C; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000327468};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          20..233
FT                   /note="E3 UFM1-protein ligase 1-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF09743"
FT   DOMAIN          485..602
FT                   /note="E3 UFM1-protein ligase 1-like"
FT                   /evidence="ECO:0000259|Pfam:PF23659"
FT   DOMAIN          608..718
FT                   /note="E3 UFM1-protein ligase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF25041"
FT   REGION          354..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   730 AA;  81972 MW;  ED538C5A19E144BB CRC64;
     MEKSSSLHHR SAERFEDELC ASRRRRINVV DLQKIINVDL VHVESRANEV AKSERGNRII
     LGQLINEHYL EQLCEEVNDK LQEAGQVNIT ELSKTQQLPA DFLTQELSAR VGRMIDGHMD
     QFSGLIFTQN FINRQKAKIR GLFSSITRPT PVNNLVGQYG LQDNLLYSLL EELVNSGRVL
     GSVVGGRQDK AVFVPDVYCR AQNAWVESFL THNAYLEFES LSRLGIPDPV NYIKKRFKDR
     KLLFLQSVCV EAAILDQLEA SVEEAVNSET WIDLQLLLPS CLSLDDSATL ISHVIHSVHA
     QSSARVLGTA VVSEKFVSSC LALFDDMMQQ KAQTEVKSDP VLLLTEDDVK LAPVMAESSS
     AKRDKREERR KKATEGSGSV RAGGGGNARE IKTRKTKKKN RREEESDDET ATTQSKPAEP
     EFLSVQEIVE VLEKRVCDCP EETLELIAHE LVRPLSRAYK EVVRSVFLSS TSASTSAGKR
     RHTAKELQEE INTLYANVRA LERGTKHFSD DVQLHMVKHI LKSVCSDLTN AMISFLSDDH
     KITMDNTNPI TAEMRMKILA KLPDEIKAPL MKLNSSLNGR SIEEFLCNVE AAAEECGIML
     KKGDKKKEKQ VLSIHKHSLM EQLQAAVDEA LVLHLTVLLL FQQHTHCMLL APGRCVSSII
     YTLQSKLPQD QYELLMQYHT LVVKRLVGKK AEQTSGESEG SAEELNELKN LTNDVKELVF
     SPRKTSTSDQ
//