ID   A0A5N5MFI5_PANHP        Unreviewed;       875 AA.
AC   A0A5N5MFI5;
DT   26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2020, sequence version 1.
DT   18-JUN-2025, entry version 18.
DE   RecName: Full=RFX-type winged-helix domain-containing protein {ECO:0000259|PROSITE:PS51526};
GN   ORFNames=PHYPO_G00044470 {ECO:0000313|EMBL:KAB5553945.1};
OS   Pangasianodon hypophthalmus (Striped catfish) (Helicophagus hypophthalmus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Pangasiidae; Pangasianodon.
OX   NCBI_TaxID=310915 {ECO:0000313|EMBL:KAB5553945.1, ECO:0000313|Proteomes:UP000327468};
RN   [1] {ECO:0000313|EMBL:KAB5553945.1, ECO:0000313|Proteomes:UP000327468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Indonesia {ECO:0000313|EMBL:KAB5553945.1,
RC   ECO:0000313|Proteomes:UP000327468};
RC   TISSUE=Blood {ECO:0000313|EMBL:KAB5553945.1};
RA   Wen M., Zahm M., Roques C., Cabau C., Klopp C., Donnadieu C., Jouanno E.,
RA   Avarre J.-C., Campet M., Ha T.T.T., Dugue R., Lampietro C., Louis A.,
RA   Herpin A., Echchiki A., Berthelot C., Parey E., Roest-Crollius H.,
RA   Braasch I., Postlethwait J., Bobe J., Montfort J., Bouchez O., Begum T.,
RA   Schartl M., Guiguen Y.;
RT   "A chromosome-scale genome assembly of the striped catfish, Pangasianodon
RT   hypophthalmus.";
RL   Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAB5553945.1}.
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DR   EMBL; VFJC01000014; KAB5553945.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A5N5MFI5; -.
DR   Proteomes; UP000327468; Chromosome 13.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR   FunFam; 1.10.10.10:FF:000017; transcription factor RFX3 isoform X1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR003150; DNA-bd_RFX.
DR   InterPro; IPR039779; RFX-like.
DR   InterPro; IPR007668; RFX1_trans_act.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12619:SF23; MHC CLASS II REGULATORY FACTOR RFX1; 1.
DR   PANTHER; PTHR12619; RFX TRANSCRIPTION FACTOR FAMILY; 1.
DR   Pfam; PF25340; BCD_RFX; 1.
DR   Pfam; PF04589; RFX1_trans_act; 1.
DR   Pfam; PF02257; RFX_DNA_binding; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51526; RFX_DBD; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000327468};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          334..409
FT                   /note="RFX-type winged-helix"
FT                   /evidence="ECO:0000259|PROSITE:PS51526"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          46..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          304..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          817..875
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..59
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..71
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        304..319
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        823..839
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   875 AA;  95392 MW;  E4AEBD4B234B0736 CRC64;
     MATPAYVGEL QQTSQPPAGA VTVTPGQPVV VTTAAPQQYL SELQNTVTSV SASATSGQVT
     PPPAQTPPTQ APPTQTQYVP AEMQNSPTQS GNAQNTPQYI VVTVTEGSIH SSDSVSDSSP
     PPAVVQTGVP TQVVQQVQSA QQRSVVQATS QPTKTEQGTQ LSVTSLQPVH LTQEQLQQVP
     VQHVYTNQVQ YVEGGDTSYT TSTIRSGSFV YTDSPLYTQT SGAQYYESTS VSVSASQAAS
     PVNTGFVTGT GQIVTSATPG TGGGATAVIA VSGTATNGSG DGGGGANGSS GSYVIQGGYM
     LSSGGGTSSS SSGNGQSYSQ NARVSPATLS SGPQVQWLLD NYETAEGVSL PRSTLYCHYL
     LHCQEQKLEP VNAASFGKLI RSVFMGLRTR RLGTRGNSKY HYYGLRIKAS SSLLRLMEDQ
     QHLAMRQQPF SQKQRLKPVQ KMEGMTNGMS SGAGQQQQQQ TSGLSDISAQ VQQYQQFLDA
     SRALPEFPEI DLQGKPLPEG IELEHIKSFQ LLYREHCEAI LDVMVNLQFT LVETLWKTFW
     RFSESQAGDT ATLAVHDESE KRLPKSCLVL LCKYEPALRW SRDCDNTLYQ GLVEILIPDV
     LRPIPSALTQ AIRNFAKSLE SWLTNAMMNI PEEMVRIKVT CANAFAQTLR RYTSLNHLAQ
     AARAVLQNTA QINQMLSDLN RVDFANVQEQ ASWVCRCEDR VVQRLEQDFK LTLQQQNSLE
     QWAAWLDGVV SQVLKPYQAS PAFPKAAKLF LLRWSFYSSM VIRDLTLRSA ASFGSFHLIR
     LLYDEYMYYL IEHRVAQAKG ETPIAVMGEF ASLGRSLNTL DPDKEEEDEE EEESDDECQE
     LALPADGAAL GEESLEPPAK LARTDQRVLF SNTEN
//