ID A0A5N5Q6E3_PANHP Unreviewed; 319 AA.
AC A0A5N5Q6E3;
DT 26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2020, sequence version 1.
DT 05-FEB-2025, entry version 14.
DE RecName: Full=Metaxin {ECO:0000256|PIRNR:PIRNR038150};
GN ORFNames=PHYPO_G00007080 {ECO:0000313|EMBL:KAB5586921.1};
OS Pangasianodon hypophthalmus (Striped catfish) (Helicophagus hypophthalmus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Pangasiidae; Pangasianodon.
OX NCBI_TaxID=310915 {ECO:0000313|EMBL:KAB5586921.1, ECO:0000313|Proteomes:UP000327468};
RN [1] {ECO:0000313|EMBL:KAB5586921.1, ECO:0000313|Proteomes:UP000327468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indonesia {ECO:0000313|EMBL:KAB5586921.1,
RC ECO:0000313|Proteomes:UP000327468};
RC TISSUE=Blood {ECO:0000313|EMBL:KAB5586921.1};
RA Wen M., Zahm M., Roques C., Cabau C., Klopp C., Donnadieu C., Jouanno E.,
RA Avarre J.-C., Campet M., Ha T.T.T., Dugue R., Lampietro C., Louis A.,
RA Herpin A., Echchiki A., Berthelot C., Parey E., Roest-Crollius H.,
RA Braasch I., Postlethwait J., Bobe J., Montfort J., Bouchez O., Begum T.,
RA Schartl M., Guiguen Y.;
RT "A chromosome-scale genome assembly of the striped catfish, Pangasianodon
RT hypophthalmus.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in transport of proteins into the mitochondrion.
CC Essential for embryonic development. {ECO:0000256|ARBA:ARBA00037753}.
CC -!- SUBUNIT: Interacts with MTX2/metaxin-2. Associates with the
CC mitochondrial contact site and cristae organizing system (MICOS)
CC complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19,
CC CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13.
CC This complex was also known under the names MINOS or MitOS complex. The
CC MICOS complex associates with mitochondrial outer membrane proteins
CC SAMM50, MTX1 and MTX2 (together described as components of the
CC mitochondrial outer membrane sorting assembly machinery (SAM) complex)
CC and DNAJC11, mitochondrial inner membrane protein TMEM11 and with
CC HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a
CC large protein complex spanning both membranes termed the mitochondrial
CC intermembrane space bridging (MIB) complex. Interacts with ARMC1.
CC {ECO:0000256|ARBA:ARBA00046575}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000256|ARBA:ARBA00004294, ECO:0000256|PIRNR:PIRNR038150}.
CC -!- SIMILARITY: Belongs to the metaxin family.
CC {ECO:0000256|ARBA:ARBA00009170, ECO:0000256|PIRNR:PIRNR038150}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAB5586921.1}.
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DR EMBL; VFJC01000002; KAB5586921.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5N5Q6E3; -.
DR OrthoDB; 5835136at2759; -.
DR Proteomes; UP000327468; Chromosome 1.
DR GO; GO:0001401; C:SAM complex; IEA:InterPro.
DR GO; GO:0007005; P:mitochondrion organization; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd03212; GST_C_Metaxin1_3; 1.
DR CDD; cd03078; GST_N_Metaxin1_like; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR017410; Metaxin1/3.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR050931; Mito_Protein_Transport_Metaxin.
DR InterPro; IPR019564; Sam37/metaxin_N.
DR PANTHER; PTHR12289; METAXIN RELATED; 1.
DR PANTHER; PTHR12289:SF34; METAXIN-1; 1.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF10568; Tom37; 1.
DR PIRSF; PIRSF038150; Metaxin; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG01180; SUF1; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787,
KW ECO:0000256|PIRNR:PIRNR038150};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000327468};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 274..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..144
FT /note="Mitochondrial outer membrane transport complex
FT Sam37/metaxin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10568"
FT DOMAIN 176..237
FT /note="Metaxin glutathione S-transferase"
FT /evidence="ECO:0000259|Pfam:PF17171"
SQ SEQUENCE 319 AA; 35871 MW; 6876415D95815A8F CRC64;
MAAPLELFCW KGSWGLPSVD TDSLIVLAYA RFAGTPLKVH KISNPWRSPT GSLPALKTKE
DGSFSQPSKI IIQLRKQKYN ADYDLSAKEG ADTLAFISLV EEKLMPALIY ALWIDPKNYV
EVTRRWHAEN ISFPLNFFLP SRMQCQQLER VRLMRGNSTL EAGEEAEKEL YSDALECMNL
LSQRLGSNRF FFGDSPSSLD AYVFGHLAPL LKIRLPSSKL QQHLKALDNL TNFCSNILSL
YFPDENREGM GQPASNVQEG SDFDHEPYKR RKQLLSVLVA VAAMLGYALL TGIVAIEHVK
EEGSRGHTAS IELQDEEEE
//
